Polyphenols: Mechanisms of Action in Human Health and Disease - 2nd Edition - ISBN: 9780128130063

Polyphenols: Mechanisms of Action in Human Health and Disease

2nd Edition

Editors: Ronald Watson Victor Preedy Sherma Zibadi
Hardcover ISBN: 9780128130063
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 512
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Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. They are a unique group of phytochemicals that are present in all fruits, vegetables and other plant products.

This very diverse and multi-functional group of active plant compounds contain powerful antioxidant properties and exhibit remarkable chemical, biological and physiological properties, including cancer prevention and cardio-protective activities.

Key Features

  • Expands coverage on green tea, cocoa, wine, cumin and herbs
  • Outlines their chemical properties, bioavailability and metabolomics
  • Provides a self-teaching guide to learn the mechanisms of action and health benefits of polyphenols


Biochemists, endocrinologists, nutritionists, dieticians, and clinical researchers interested in how the mechanisms of polyphenols contribute to the prevention and treatment of disease

Table of Contents

1. Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health
2. Polyphenols and Public Health
3. The History of Islamic Medicine at a Glance
4. Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability
5. Biological Activities of Polyphenols from Grapes
6. The Atomic Level Interaction of Polyphenols with the Aβ Oligomer Aggregate: A Molecular Dynamic Guidance for Rational Drug Design
7. Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks

BIOAVAILABILITY – possible new section
8. Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes
9. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters
10. Microorganism Metabolic Activity Stimulation by Polyphenols
11. Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds
12. Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans
13. Uptake and Metabolism of Dietary Proanthocyanidins
14. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids
15. Microbial Metabolism of Polyphenols and Health
16. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview

17. Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases
18. Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Ac¸a´ı (Euterpe spp.)
19. Dark Chocolate/Cocoa Polyphenols and Oxidative Stress
20. Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion
21. Antioxidant Role of Catechin in Health and Disease
22. Cytoprotective Effects of Polyphenols against Oxidative Damage
23. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
24. Polyphenols and Low Iron Bioavailability
25. Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems
26. Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins

27. Anthocyanins and Diabetes Regulation
28. Influence of Dietary Polyphenols on Carbohydrate Metabolism
29. Polyphenols in Ayurvedic Medicine and Type 2 Diabetes
30. Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia
31. Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea
32. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids
33. Dietary Quercetin and other Polyphenols: Attenuation of Obesity
34. Role of Protocatechuic Acid in Obesity-Related Pathologies
35. Food and Supplement Polyphenol Action in Cancer Recurrence
36. Polyphenols from Pongamia pinnata (Linn.) Pierre in Metabolic Disorder
37. Garlic (Allium sativum): Role in Metabolic Disorder
38. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis
39. Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols

40. Plant Polyphenols as Dietary Modulators of Brain Functions
41. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells
42. Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease
43. Anti-Inflammatory Properties of Cinnamon Polyphenols and their Monomeric Precursors
44. Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations
45. Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids
46. Immunomodulatory Ethnobotanicals of the Great Lakes
47. Pongamia pinnata (Linn.) Pierre and Inflammation
48. Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms

49. Polyphenols and Skin Cancers
50. Polyphenols in the Prevention of Ulcerative Colitis
51. Protection and Reversal of Hepatic Fibrosis by Polyphenols
52. Hepatoprotective Effects of Green Tea and its Polyphenols
53. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture
54. Polyphenolics Evoke Healing Responses
55. Polyphenols and Reproductive Health
56. Polyphenols and Tuberculosis
57. Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity
58. Safety of High and Long-term Intake of Polyphenols
59. Polyphenols in Health and Disease
60. Curcumin/Turmeric as an Environment-friendly Stain for Proteins on Acrylamide Gels
61. Turmeric and its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis
62. Polyphenols and Skin Cancers
63. Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis
64. Polyphenols against Skin Aging
65. Skin Photoprotection by Polyphenols in Animal Models and Humans
66. Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering
67. Studying Tea Polyphenols and Their Protective Effects on Skin
68. Polyphenols: A Remedy for Skin Wrinkles


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© Academic Press 2019
Academic Press
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About the Editor

Ronald Watson

Ronald Ross Watson PhD is a professor of Health Promotion Sciences in the University of Arizona Mel and Enid Zuckerman College of Public Health. He was one of the founding members of this school serving the mountain west of the USA. He is a professor of Family and Community Medicine in the School of Medicine at the University of Arizona. He began his research in public health at the Harvard School of Public Health as a fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia, and USA which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring at a Lt. Colonel. He published 450 papers, and presently directs or has directed several NIH funded biomedical grants relating to alcohol and disease particularly immune function and cardiovascular effects including studying complementary and alternative medicines. Professor Ronald Ross Watson was Director of a National Institutes of Health funded Alcohol Research Center for 5 years. The main goal of the Center was to understand the role of ethanol-induced immunosuppression on immune function and disease resistance in animals. He is an internationally recognized alcohol-researcher, nutritionist and immunologist. He also initiated and directed other NIH-associated work at The University of Arizona, College of Medicine. Dr. Watson has funding from companies and non-profit foundations to study bioactive foods’ components in health promotion. Professor Watson attended the University of Idaho, but graduated from Brigham Young University in Provo, Utah, with a degree in Chemistry in 1966. He completed his Ph.D. degree in 1971 in Biochemistry from Michigan State University. His postdoctoral schooling was completed at the Harvard School of Public Health in Nutrition and Microbiology, including a two-year postdoctoral research experience in immunology. Professor Watson is a distinguished member of several national and international nutrition, immunology, and cancer societies. Overall his career has involved studying many foods for their uses in health promotion. He has edited 120 biomedical reference books, particularly in health and 450 papers and chapters. His teaching and research in foods, nutrition and bacterial disease also prepare him to edit this book. He has 4 edited works on nutrition in aging. He has extensive experience working with natural products, alcohol, exercise, functional foods and dietary extracts for health benefits and safety issues, including getting 12 patents. Dr. Watson has done laboratory studies in mice on immune functions that decline with aging and the role of supplements in delaying this process as modified by alcohol and drugs of abuse.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health and School of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine.

Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier).

Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry.

To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Faculty of Life Sciences and Medicine, King's College London, UK

Sherma Zibadi

Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi’s research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.

Affiliations and Expertise

Postdoctoral Research Associate of Public Health, Department of Pathology, University of South Florida Medical School, Tampa, USA

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