Polyphenols: Mechanisms of Action in Human Health and Disease - 2nd Edition - ISBN: 9780128130063

Polyphenols: Mechanisms of Action in Human Health and Disease

2nd Edition

Hardcover ISBN: 9780128130063
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 800
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Polyphenols are a unique group of phytochemicals that are present in all fruits, vegetables, and other plant products. They are a very diverse and multi-functional group of active plant compounds with powerful antioxidant properties. They exhibit remarkable chemical, biological and physiological properties, including antioxidant, cancer prevention, and cardio-protective activities. Mechanisms of Action of Polyphenols in Human Health and Disease, Second Edition, describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system.

Key Features

  • Expands coverage on green tea, cocoa, wine, cumin and herbs
  • Outlines chemical properties, bioavailability and metabolomics of polyphenols to understand their antioxidant mechanisms
  • Provides a self-teaching guide to learn the mechanisms of action and health benefits of polyphenols


Biochemists, endocrinologists, nutritionists, dieticians, and clinical researchers interested in how the mechanisms of polyphenols contribute to the prevention and treatment of disease

Table of Contents

1. Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health
2. Polyphenols and Public Health
3. The History of Islamic Medicine at a Glance
4. Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability
5. Biological Activities of Polyphenols from Grapes
6. The Atomic Level Interaction of Polyphenols with the Aβ Oligomer Aggregate: A Molecular Dynamic Guidance for Rational Drug Design
7. Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks

BIOAVAILABILITY – possible new section
8. Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes
9. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters
10. Microorganism Metabolic Activity Stimulation by Polyphenols
11. Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds
12. Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans
13. Uptake and Metabolism of Dietary Proanthocyanidins
14. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids
15. Microbial Metabolism of Polyphenols and Health
16. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview

17. Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases
18. Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Ac¸a´ı (Euterpe spp.)
19. Dark Chocolate/Cocoa Polyphenols and Oxidative Stress
20. Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion
21. Antioxidant Role of Catechin in Health and Disease
22. Cytoprotective Effects of Polyphenols against Oxidative Damage
23. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
24. Polyphenols and Low Iron Bioavailability
25. Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems
26. Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins

27. Anthocyanins and Diabetes Regulation
28. Influence of Dietary Polyphenols on Carbohydrate Metabolism
29. Polyphenols in Ayurvedic Medicine and Type 2 Diabetes
30. Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia
31. Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea
32. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids
33. Dietary Quercetin and other Polyphenols: Attenuation of Obesity
34. Role of Protocatechuic Acid in Obesity-Related Pathologies
35. Food and Supplement Polyphenol Action in Cancer Recurrence
36. Polyphenols from Pongamia pinnata (Linn.) Pierre in Metabolic Disorder
37. Garlic (Allium sativum): Role in Metabolic Disorder
38. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis
39. Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols

40. Plant Polyphenols as Dietary Modulators of Brain Functions
41. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells
42. Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease
43. Anti-Inflammatory Properties of Cinnamon Polyphenols and their Monomeric Precursors
44. Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations
45. Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids
46. Immunomodulatory Ethnobotanicals of the Great Lakes
47. Pongamia pinnata (Linn.) Pierre and Inflammation
48. Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms

49. Polyphenols and Skin Cancers
50. Polyphenols in the Prevention of Ulcerative Colitis
51. Protection and Reversal of Hepatic Fibrosis by Polyphenols
52. Hepatoprotective Effects of Green Tea and its Polyphenols
53. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture
54. Polyphenolics Evoke Healing Responses
55. Polyphenols and Reproductive Health
56. Polyphenols and Tuberculosis
57. Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity
58. Safety of High and Long-term Intake of Polyphenols
59. Polyphenols in Health and Disease
60. Curcumin/Turmeric as an Environment-friendly Stain for Proteins on Acrylamide Gels
61. Turmeric and its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis
62. Polyphenols and Skin Cancers
63. Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis
64. Polyphenols against Skin Aging
65. Skin Photoprotection by Polyphenols in Animal Models and Humans
66. Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering
67. Studying Tea Polyphenols and Their Protective Effects on Skin
68. Polyphenols: A Remedy for Skin Wrinkles


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