Polymyositis and Dermatomyositis

Polymyositis and Dermatomyositis

1st Edition - March 23, 1988

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  • Editor: Marinos C Dalakas
  • eBook ISBN: 9781483163048

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Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Table of Contents

  • Contributing Authors


    1. A Classification of Polymyositis and Dermatomyositis

    I. Clinical Features

    2. Clinical Presentation and Diagnosis of Polymyositis and Dermatomyositis

    3. Association of Inflammatory Myopathies with Other Connective Tissue Disorders and Malignancies

    4. Inflammatory Myopathies of Childhood

    II. Etiology and Mechanisms

    5. Immunopathology of Polymyositis and Dermatomyositis

    6. Viral Etiology of Polymyositis/Dermatomyositis

    7. Inclusion Body Myositis

    8. Animal Models of Polymyositis and Dermatomyositis

    III. Diagnosis and Treatment

    9. Histopathology of the Inflammatory Myopathies

    10. Resin Histology and Electron Microscopy in Inflammatory Myopathies

    11. Electromyography in Polymyositis and Dermatomyositis (PM/DM)

    12. Treatment of Polymyositis and Dermatomyositis with Corticosteroids: A First Therapeutic Approach

    13. Nonsteroidal Immunosuppressive Therapy in Polymyositis and Dermatomyositis

    14. Total Body Irradiation in the Treatment of Intractable Polymyositis and Dermatomyositis

    15. Comprehensive Rehabilitative Management of Patients with Polymyositis and Dermatomyositis

    16. Fibromyalgia Syndrome and Chronic Epstein-Barr Virus/Chronic Fatigue Syndrome

    IV. Overview

    17. Polymyositis and Dermatomyositis: An Overview


Product details

  • No. of pages: 360
  • Language: English
  • Copyright: © Butterworth-Heinemann 1988
  • Published: March 23, 1988
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483163048

About the Editor

Marinos C Dalakas

Dr. Marinos Dalakas is Professor of Neurology and Director of the Neuromuscular Division at Thomas Jefferson University School of Medicine in Philadelphia. He is Professor of Neurology and Chief of the Neuroimmunology Laboratory in the Department of Pathophysiology at the University of Athens Medical School in Athens, where he has been Emeritus Professor since 2016. Dr. Dalakas is an appointed member in various scientific societies and is a member of the American Neurological Association, the American Academy of Neurology, the European Neurological Society, and the International Society of Greek Neuroscientists, among other professional organizations. Dr. Dalakas has published widely. His areas of research are broad and include neuroimmunology, neurovirology, genetics, and immunotherapies in neurologic diseases. He has focused on neuropathies, myopathies, dystrophies, ALS, multiple sclerosis, and various autoimmune neurological disorders, with the application and design of new treatments. He completed a 3-year fellowship training in neuromuscular diseases at the Medical Neurology Branch of the NINCDS in Bethesda, Maryland and an additional 5-year training in Neuroimmunology/Neurovirology at NINDS. He subsequently served as Chief of the Neuromuscular Diseases Section of the NINDS, NIH, a position he held for 20 years before joining Thomas Jefferson University.

Affiliations and Expertise

Professor of Neurology, Thomas Jefferson University School of Medicine, Philadelphia, USA

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