Polycyclic hydrocarbons and cancer

Polycyclic hydrocarbons and cancer

1st Edition - January 28, 1981

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  • Editor: Harry Gelboin
  • eBook ISBN: 9780323153911

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Description

Polycyclic Hydrocarbons and Cancer, Volume 3 explores the link between polycyclic aromatic hydrocarbons (PAHs) and cancer based on research in the fields of chemistry, biology, and the medical and social sciences. Topics covered include the metabolism of polynuclear aromatic hydrocarbons; carcinogenicity of PAHs and their derivatives; the role of microsomal epoxide hydrolase in the biotransformation of PAHs; and biochemical effects of the phorbol ester tumor promoters and their implications for PAH carcinogenesis. This volume consists of eight chapters and begins with a discussion on the mechanisms of PAH metabolism in the marine environment. The use of X-ray crystallographic techniques in studying carcinogenic PAHs and their derivatives is then considered, along with the involvement of dihydrodiols and diol epoxides in the metabolic activation of PAHs other than benzo[a]pyrene; the role of microsomal epoxide hydrolase in PAH biotransformation; and drug detoxication in relation to the excretion mechanism of chemical carcinogens. The following chapters focus on the anticarcinogenic or inhibitory effects of a variety of chemicals on PAH carcinogenesis; the biochemical effects of the phorbol ester tumor promoters on PAH carcinogenesis; and epidemiology of PAHs, with emphasis on quantification of the cancer risk from cigarette smoking and air pollution. This monograph will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in the fields of chemistry, biology, and the medical and social sciences.

Table of Contents


  • List of Contributors

    Preface

    Contents of Previous Volumes

    1 Polynuclear Aromatic Hydrocarbons and Their Metabolism in the Marine Environment

    I. Introduction

    II. PAH in the Marine Environment

    III. Monooxygenase Activity in Aquatic Species

    IV. Induction of Cytochrome P-450

    V. Patterns of Metabolism of PAH

    VI. PAH Carcinogenesis in Marine Species

    VII. Environmental Health Implications

    VIII. Conclusion

    References

    2 X-Ray Crystallographic Studies on Carcinogenic Polycyclic Aromatic Hydrocarbons and Their Derivatives

    I. Introduction

    II. Polycyclic Aromatic Hydrocarbons

    III. Comparisons with Other Structures

    IV. Interactions of Carcinogens with Proteins

    V. Interactions of Carcinogens with Nucleic Acids

    VI. Summary

    References

    3 Involvement of Dihydrodiols and Diol Epoxides in the Metabolic Activation of Polycyclic Hydrocarbons Other than Benzo[a]Pyrene

    I. Introduction

    II. General Pathways of Hydrocarbon Metabolism

    III. Metabolic Activation involving Dihydrodiols and Diol Epoxides

    IV. Factors Affecting Dihydrodiol and Diol Epoxide Formation

    V. Factors Influencing Hydrocarbon Activation

    VI. Concluding Remarks

    References

    4 Microsomal Epoxide Hydrolase and Its Role in Polycyclic Aromatic Hydrocarbon Biotransformation

    I. Introduction

    II. Physical Characterization of Epoxide Hydrolase

    III. Biochemical Properties of Epoxide Hydrolase

    IV. Distribution and Regulation of Epoxide Hydrolase Activity

    V. Participation of Epoxide Hydrolase in Metabolic Activation and Deactivation of Polycyclic Aromatic Hydrocarbons

    VI. Conclusion

    References

    5 Glutathione, Glucuronide, and Sulfate Transferase in Polycyclic Aromatic Hydrocarbon Metabolism

    I. Introduction

    II. Conjugates of Polycyclic Aromatic Hydrocarbons (PAH) In Vivo

    III. Metabolites of PAH in Cultured Cells

    IV. GSH 5-Epoxide Transferase

    V. UDP-Glucuronyl Transferase

    VI. Sulfotransferase

    VII. Effects on Biological Activities of PAH

    VIII. Implications of Conjugation Reactions for Carcinogenesis

    IX. Conclusion

    References

    6 Modification of Polycyclic Aromatic Hydrocarbon Carcinogenesis

    I. Introduction

    II. Antioxidants

    III. Flavones

    IV. Halogenated Hydrocarbons

    V. Weakly or Noncarcinogenic PAH

    VI. Anti-inflammatory Steroids

    VII. Prostaglandin Synthesis Inhibitors

    VIII. Miscellaneous Agents

    IX. Summary

    References

    7 Biochemical Effects of the Phorbol Ester Tumor Promoters and Their Implications for Polycyclic Aromatic Hydrocarbon Carcinogenesis

    I. Introduction

    II. Initiation and Promotion

    III. Mimicry of Transformation and Enhancement

    IV. Modulation of Differentiation by Phorbol Esters

    V. Effect of Tumor Promoters on Blood Elements

    VI. Relationship of Tumor Promoters to Virus Transformation

    VII. Evidence that Cells Contain High-Affinity Phorboid Receptors: Possible Significance during Growth and Development

    VIII. Phorbol Ester-Induced Changes in Phospholipid Metabolism

    IX. Phorbol Esters and Calcium Metabolism

    X. Mediation by Ah Receptor of the Tumor-Promoting Activity of Polycyclic Aromatic Hydrocarbons

    XI. A Unified Theory of Initiation and Promotion

    References

    8 Epidemiology of Polycyclic Hydrocarbons: Quantifying the Cancer Risk from Cigarette Smoking and Air Pollution

    I. Introduction

    II. Cigarette Smoking and Lung Cancer

    III. Air Pollution and Lung Cancer

    IV. Conclusions

    References

    Index

Product details

  • No. of pages: 367
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323153911

About the Editor

Harry Gelboin

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