Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation

1st Edition - November 18, 2017

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  • Editor: Robert Goodnow
  • Hardcover ISBN: 9780128130698
  • eBook ISBN: 9780128130704

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Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides.

Key Features

  • Unique for its treatment of platform technologies for medicinal chemistry and target validation
  • Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field
  • Presents state-of-the-art summaries of platform technologies


Ideally suited for chemists engaged in multidisciplinary teams for drug discovery including medicinal chemists and others involved in chemical biology and bio-organic disciplines and computational chemistry

Table of Contents

  • 1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery
    Robert A. Goodnow Jr. and Christopher P. Davie
    2. The Chemistry of Oligonucleotide Delivery
    David B. Rozema
    3. CRISPR–Cas9 for Drug Discovery in Oncology
    Sylvie M. Guichard
    4. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry
    László Ürge, Jesus Alcazar, Lena Huck and György Dormán
    5. High-Throughput Screening
    Mary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick
    6. Kinase-Centric Computational Drug Development
    Albert J. Kooistra and Andrea Volkamer
    7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead Optimization
    Robert Abel and Sathesh Bhat
    8. Phenotypic Screening
    Alleyn T. Plowright and Lauren Drowley
    9. Targeted Protein Degradation
    Nello Mainolfi and Tim Rasmusson
    10. Chemical Biology in Drug Discovery
    M. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks
    11. Fragment-Based Lead Discovery
    Ben J. Davis and Stephen D. Roughley
    12. Antibody-Drug Conjugates
    Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao
    13. Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics
    Patrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang
    14. A Decade of Deuteration in Medicinal Chemistry
    Julie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller
    15. From Natural Peptides to Market
    Claudio D. Schteingart and Jolene L. Lau

Product details

  • No. of pages: 690
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: November 18, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128130698
  • eBook ISBN: 9780128130704

About the Serial Volume Editor

Robert Goodnow

Robert Goodnow
Robert A. Goodnow, Jr. is currently Vice President, Chemistry Innovation at Pharmaron, Inc in Boston, MA. He completed a Ph.D. in bioorganic chemistry at Columbia University, New York, USA, followed by postdoctoral training at Princeton University, New Jersey, USA. He has worked at Roche and AstraZeneca, focusing on new lead and target discovery as well as implementing chemistry technologies in support of early drug discovery. He is the editor and author of The Handbook of DNA-Encoded Chemistry, which was published in 2014 by Wiley.

Affiliations and Expertise

Pharmaron, Boston, USA

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