Platelets - 2nd Edition - ISBN: 9780123693679, 9780080465869

Platelets

2nd Edition

Editors: Alan Michelson
Authors: Alan Michelson
eBook ISBN: 9780080465869
Hardcover ISBN: 9780123693679
Imprint: Academic Press
Published Date: 26th October 2006
Page Count: 1376
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Description

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Key Features

· First edition won Best Book in Medical Science Award from the Association of American Publishers

· Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias

· A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Readership

Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Table of Contents

Foreword A Brief History of Ideas About Platelets in Health and Disease. Barry S. Coller

Part One: Platelet Biology

  1. The Evolution of Mammalian Platelets. Jack Levin
  2. Megakaryocyte Development and Platelet Formation. Joseph E. Italiano, Jr., John H. Hartwig
  3. Platelet Structure. James G. White
  4. The Platelet Cytoskeleton. John H. Hartwig
  5. Platelet Genomics and Proteomics. Ángel García, Yotis Senis, Michael G. Tomlinson, Steve P. Watson
  6. Platelet Receptors. Kenneth J. Clemetson, Jeannine M. Clemetson
  7. The Glycoprotein Ib-IX-V Complex. Robert K. Andrews, Michael C. Berndt, José A. López
  8. Integrin αIIbβ3. Edward F. Plow, Michelle Pesho, Yan-Qing Ma
  9. Thrombin Receptors. Wadie F. Bahou
  10. The Platelet P2 Receptors. Marco Cattaneo
  11. PECAM-1. Melanie S. Novinska, Vipul Rathore, Debra K. Newman, Peter J. Newman
  12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium. Rodger P. McEver
  13. Inhibition of Platelet Function by the Endothelium. Sybille Rex, Jane E. Freedman
  14. Platelet Polymorphisms. Vahid Afshar-Kharghan, K. Vinod Vijayan, Paul F. Bray
  15. Platelet Secretion. Guy L. Reed
  16. Signal Transduction During the Platelet Plug Formation. Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Donna S. Woulfe
  17. Outside-in Signaling By Integrin αIIbβ3. Nicolas Prévost, Sanford J. Shattil
  18. Platelet Thrombus Formation in Flowing Blood. Brian Savage, Zaverio M. Ruggeri
  19. Interactions Between Platelets and the Coagulation System. Beth A. Bouchard, Saulius Butenas, Kenneth G. Mann, Paula B. Tracy
  20. Platelet-Derived Microparticles. Rienk Nieuwland, Augueste Sturk
  21. The Role of Platelets in Fibrinolysis. Bradley A. Maron, Joseph Loscalzo
  22. Platelet Function in the Newborn. Sara J. Israels

Part Two: Tests of Platelet Function

  1. Clinical Tests of Platelet Function. Paul Harrison, David Keeling
  2. Platelet Counting. Carol Briggs, Paul Harrison, Samuel J. Machin
  3. The Bleeding Time. Stuart E. Lind, Carla D. Kurkjian
  4. Platelet Aggregation. Lisa K. Jennings, Melanie McCabe White
  5. The VerifyNow System. Steven R. Steinhubl
  6. Platelet Function Analyzer (PFA)-100. John L. Francis
  7. Impact Cone and Plate(let) Analyzer. David Varon, Naphtali Savion
  8. Flow Cytometry. Alan D. Michelson, Matthew D. Linden, Marc R. Barnard, Mark. I. Furman, A.L. Frelinger III
  9. Thromboxane Generation. Tilo Grosser, Susanne Fries, Garret A. FitzGerald
  10. Perfusion Chambers. Philip G. de Groot, Jan J. Sixma
  11. Animal Models. David H. Lee, Morris A. Blajchman
  12. Real Time In Vivo Imaging of Platelets During Thrombus Formation. Christophe Dubois, Ben Atkinson, Barbara Furie, Bruce Furie

Part Three: The Role of Platelets in Disease

  1. Atherothrombosis and Coronary Artery Disease. Pascal J. Goldschmidt, Neuza Lopes, Lawrence E. Crawford, Richard C. Becker
  2. Central Nervous System Ischemia. Gregory J. del Zoppo
  3. Peripheral Vascular Disease. Michael Sobel
  4. Diabetes Mellitus. Bernd Stratmann, Barbara Menart, Diethelm Tschoepe
  5. Inflammation. Wolfgang Bergmeier, Denisa D. Wagner
  6. Antimicrobial Host Defense. Michael R. Yeaman, Arnold S. Bayer
  7. Angiogenesis. Alexander Brill, David Varon
  8. Tumor Growth and Metastasis. Mary Lynn Nierodzik, Simon Karpatkin
  9. Alzheimer’s Disease. Qiao-Xin Li, Colin L. Masters
  10. Psychiatric Disorders. George N. M. Gurguis

Part Four: Disorders of Platelet Number and Function

  1. The Clinical Approach to Disorders of Platelet Number and Function. Alan D. Michelson
  2. Immune Thrombocytopenic Purpura. James B. Bussel
  3. HIV-1-related Thrombocytopenia. Michael A. Nardi, Zongdong Li, Simon Karpatkin
  4. Heparin-induced Thrombocytopenia. Beng H. Chong
  5. Drug-induced Thrombocytopenia. Richard H. Aster
  6. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome. Joel L. Moake
  7. Thrombocytopenia in Pregnancy. Keith R. McCrae
  8. Thrombocytopenia in the Newborn. Irene A. G. Roberts, Neil A. Murray
  9. Alloimmune Thrombocytopenia. Cecile Kaplan, John Freedman
  10. Inherited Thrombocytopenias. Michele P. Lambert, Mortimer Poncz
  11. Pseudothrombocytopenia. Nicola Bizzaro
  12. Thrombocytosis and Essential Thrombocythemia. Ayalew Tefferi
  13. Inherited Disorders of Platelet Function. Alan T. Nurden, Paquita Nurden
  14. Acquired Disorders of Platelet Function. A. Koneti Rao
  15. Cardiopulmonary Bypass. Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

Part Five: Pharmacology: Antiplatelet Therapy

  1. Aspirin. Eric H. Awtry, Joseph Loscalzo
  2. ADP Receptor Antagonists. Marco Cattaneo
  3. αIIbβ3 (GPIIb-IIIa) Antagonists. Ramtin Agah, Edward F. Plow, Eric J. Topol
  4. Dipyridamole. Wolfgang G. Eisert
  5. Cilostazol. Yasuo Ikeda, Toshiki Sudo, Yukio Kimura
  6. Experimental Antiplatelet Therapy. Anthony A. Bavry, Deepak L. Bhatt, Eric J. Topol

Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function

  1. Platelet Growth Factors. David J. Kuter
  2. Desmopressin (DDAVP). Pier Mannuccio Mannucci, Marco Cattaneo
  3. Factor VIIa. Man-Chiu Poon

Part Seven: Platelet Transfusion Medicine

  1. Platelet Storage and Transfusion. Peter L. Perrotta, Edward L. Snyder
  2. Platelet Substitutes and Novel Methods of Platelet Preservation. David H. Lee, Morris A. Blajchman

Part Eight: Gene Therapy for Platelet Disorders

  1. Gene Therapy for Platelet Disorders. David A. Wilcox, Gilbert C. White II

Details

No. of pages:
1376
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080465869
Hardcover ISBN:
9780123693679

About the Editor

Alan Michelson

Dr. Alan D. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is also the Director of the Center for Platelet Research Studies and the Director of the Thrombosis Program and Anticoagulation Service at Children's Hospital Boston. After receiving his medical degree with honors from the University of Adelaide, Australia in 1974, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Children’s Hospital Boston, Brigham and Women’s Hospital, and Harvard Medical School. He has been the principal investigator on approximately 100 research grants and has published over 400 original research articles, original research abstracts, and invited reviews. Dr. Michelson has been an invited speaker at over 180 major medical conferences worldwide and has been an invited participant at numerous national and international consensus conferences and workshops, including Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. He is the inventor on two U.S. patents.

Affiliations and Expertise

Director, Center for Platelet Research Studies; Director, Thrombosis Program and Anticoagulation Service, Division of Hematology/Oncology, Children's Hospital Boston, Professor of Pediatric Medicine, Harvard University Medical School, Boston, MA, USA

About the Author

Alan Michelson

Dr. Alan D. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is also the Director of the Center for Platelet Research Studies and the Director of the Thrombosis Program and Anticoagulation Service at Children's Hospital Boston. After receiving his medical degree with honors from the University of Adelaide, Australia in 1974, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Children’s Hospital Boston, Brigham and Women’s Hospital, and Harvard Medical School. He has been the principal investigator on approximately 100 research grants and has published over 400 original research articles, original research abstracts, and invited reviews. Dr. Michelson has been an invited speaker at over 180 major medical conferences worldwide and has been an invited participant at numerous national and international consensus conferences and workshops, including Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. He is the inventor on two U.S. patents.

Affiliations and Expertise

Director, Center for Platelet Research Studies; Director, Thrombosis Program and Anticoagulation Service, Division of Hematology/Oncology, Children's Hospital Boston, Professor of Pediatric Medicine, Harvard University Medical School, Boston, MA, USA

Reviews

"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars) "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." -Michael J. Domanski, MD, National Heart Lung and Blood Institute, in JAMA "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY