Platelets

Platelets

2nd Edition - October 26, 2006

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  • Editor: Alan Michelson
  • eBook ISBN: 9780080465869

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Description

Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Key Features

  • First edition won Best Book in Medical Science Award from the Association of American Publishers
  • Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias
  • A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Readership

Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Table of Contents

  • Foreword
    A Brief History of Ideas About Platelets in Health and Disease
    Barry S. Coller

    Part One: Platelet Biology
    1. The Evolution of Mammalian Platelets
    Jack Levin
    2. Megakaryocyte Development and Platelet Formation
    Joseph E. Italiano, Jr., John H. Hartwig
    3. Platelet Structure
    James G. White
    4. The Platelet Cytoskeleton
    John H. Hartwig
    5. Platelet Genomics and Proteomics
    Angel García, Yotis Senis, Michael G. Tomlinson, Steve P. Watson
    6. Platelet Receptors
    Kenneth J. Clemetson, Jeannine M. Clemetson
    7. The Glycoprotein Ib-IX-V Complex
    Robert K. Andrews, Michael C. Berndt, José A. López
    8. Integrin αIIbβ3
    Edward F. Plow, Michelle Pesho, Yan-Qing Ma
    9. Thrombin Receptors
    Wadie F. Bahou
    10. The Platelet P2 Receptors
    Marco Cattaneo
    11. PECAM-1
    Melanie S. Novinska, Vipul Rathore, Debra K. Newman, Peter J. Newman
    12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium
    Rodger P. McEver
    13. Inhibition of Platelet Function by the Endothelium
    Sybille Rex, Jane E. Freedman
    14. Platelet Polymorphisms
    Vahid Afshar-Kharghan, K. Vinod Vijayan, Paul F. Bray
    15. Platelet Secretion
    Guy L. Reed
    16. Signal Transduction During the Platelet Plug Formation
    Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Donna S. Woulfe
    17. Outside-in Signaling By Integrin αIIbβ3
    Nicolas Prévost, Sanford J. Shattil
    18. Platelet Thrombus Formation in Flowing Blood
    Brian Savage, Zaverio M. Ruggeri
    19. Interactions Between Platelets and the Coagulation System
    Beth A. Bouchard, Saulius Butenas, Kenneth G. Mann, Paula B. Tracy
    20. Platelet-Derived Microparticles
    Rienk Nieuwland, Augueste Sturk
    21. The Role of Platelets in Fibrinolysis
    Bradley A. Maron, Joseph Loscalzo
    22. Platelet Function in the Newborn
    Sara J. Israels

    Part Two: Tests of Platelet Function
    23. Clinical Tests of Platelet Function
    Paul Harrison, David Keeling
    24. Platelet Counting
    Carol Briggs, Paul Harrison, Samuel J. Machin
    25. The Bleeding Time
    Stuart E. Lind, Carla D. Kurkjian
    26. Platelet Aggregation
    Lisa K. Jennings, Melanie McCabe White
    27. The VerifyNow System
    Steven R. Steinhubl
    28. Platelet Function Analyzer (PFA)-100
    John L. Francis
    29. Impact Cone and Plate(let) Analyzer
    David Varon, Naphtali Savion
    30. Flow Cytometry
    Alan D. Michelson, Matthew D. Linden, Marc R. Barnard, Mark. I. Furman, A.L. Frelinger III
    31. Thromboxane Generation
    Tilo Grosser, Susanne Fries, Garret A. FitzGerald
    32. Perfusion Chambers
    Philip G. de Groot, Jan J. Sixma
    33. Animal Models
    David H. Lee, Morris A. Blajchman
    34. Real Time In Vivo Imaging of Platelets During Thrombus Formation
    Christophe Dubois, Ben Atkinson, Barbara Furie, Bruce Furie

    Part Three: The Role of Platelets in Disease
    35. Atherothrombosis and Coronary Artery Disease
    Pascal J. Goldschmidt, Neuza Lopes, Lawrence E. Crawford, Richard C. Becker
    36. Central Nervous System Ischemia
    Gregory J. del Zoppo
    37. Peripheral Vascular Disease
    Michael Sobel
    38. Diabetes Mellitus
    Bernd Stratmann, Barbara Menart, Diethelm Tschoepe
    39. Inflammation
    Wolfgang Bergmeier, Denisa D. Wagner
    40. Antimicrobial Host Defense
    Michael R. Yeaman, Arnold S. Bayer
    41. Angiogenesis
    Alexander Brill, David Varon
    42. Tumor Growth and Metastasis
    Mary Lynn Nierodzik, Simon Karpatkin
    43. Alzheimer’s Disease
    Qiao-Xin Li, Colin L. Masters
    44. Psychiatric Disorders
    George N. M. Gurguis

    Part Four: Disorders of Platelet Number and Function
    45. The Clinical Approach to Disorders of Platelet Number and Function
    Alan D. Michelson
    46. Immune Thrombocytopenic Purpura
    James B. Bussel
    47. HIV-1-related Thrombocytopenia
    Michael A. Nardi, Zongdong Li, Simon Karpatkin
    48. Heparin-induced Thrombocytopenia
    Beng H. Chong
    49. Drug-induced Thrombocytopenia
    Richard H. Aster
    50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome
    Joel L. Moake
    51. Thrombocytopenia in Pregnancy
    Keith R. McCrae
    52. Thrombocytopenia in the Newborn
    Irene A. G. Roberts, Neil A. Murray
    53. Alloimmune Thrombocytopenia
    Cecile Kaplan, John Freedman
    54. Inherited Thrombocytopenias
    Michele P. Lambert, Mortimer Poncz
    55. Pseudothrombocytopenia
    Nicola Bizzaro
    56. Thrombocytosis and Essential Thrombocythemia
    Ayalew Tefferi
    57. Inherited Disorders of Platelet Function
    Alan T. Nurden, Paquita Nurden
    58. Acquired Disorders of Platelet Function
    A. Koneti Rao
    59. Cardiopulmonary Bypass
    Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

    Part Five: Pharmacology: Antiplatelet Therapy
    60. Aspirin
    Eric H. Awtry, Joseph Loscalzo
    61. ADP Receptor Antagonists
    Marco Cattaneo
    62. αIIbβ3 (GPIIb-IIIa) Antagonists
    Ramtin Agah, Edward F. Plow, Eric J. Topol
    63. Dipyridamole
    Wolfgang G. Eisert
    64. Cilostazol
    Yasuo Ikeda, Toshiki Sudo, Yukio Kimura
    65. Experimental Antiplatelet Therapy
    Anthony A. Bavry, Deepak L. Bhatt, Eric J. Topol

    Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function
    66. Platelet Growth Factors
    David J. Kuter
    67. Desmopressin (DDAVP)
    Pier Mannuccio Mannucci, Marco Cattaneo
    68. Factor VIIa
    Man-Chiu Poon

    Part Seven: Platelet Transfusion Medicine
    69. Platelet Storage and Transfusion
    Peter L. Perrotta, Edward L. Snyder
    70. Platelet Substitutes and Novel Methods of Platelet Preservation
    David H. Lee, Morris A. Blajchman

    Part Eight: Gene Therapy for Platelet Disorders
    71. Gene Therapy for Platelet Disorders
    David A. Wilcox, Gilbert C. White II

Product details

  • No. of pages: 1376
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: October 26, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080465869

About the Editor

Alan Michelson

Alan Michelson
Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.

Affiliations and Expertise

Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, MA, USA; Director, Center for Platelet Research Studies and Director, Thrombosis and Anticoagulation Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA

About the Author

Alan Michelson

Alan Michelson
Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.

Affiliations and Expertise

Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, MA, USA; Director, Center for Platelet Research Studies and Director, Thrombosis and Anticoagulation Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA

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