Plasma Medical Science - 1st Edition - ISBN: 9780128150047

Plasma Medical Science

1st Edition

Editors: Shinya Toyokuni Masaru Hori Yuzuru Ikehara Yuzuru Ikehara Fumitaka Kikkawa Fumitaka Kikkawa Masaru Hori
Paperback ISBN: 9780128150047
Imprint: Academic Press
Published Date: 20th July 2018
Page Count: 350
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Description

Plasma Medical Science is a new academic field that combines plasma science and medical science. Recently, non-thermal atmospheric pressure plasma has been applied for a wide variety of medical fields such as wound healing, blood coagulation, and cancer therapy. However, the mechanisms of biological effects by plasma treatments were not fully understood to develop rational treatments in medical practices. In this book, we describe the progress in Plasma Medical Science over past five years, illustrating what readers must share the scientific principles of Plasma Medicine.

Key Features

  • Provides a dedicated reference for this emerging topic
  • Discusses the state of art of developments in plasma technology
  • Introduces topics of plasma biophysics and biochemistry required to understand the application of the technology for plasma medicine
  • Brings together diverse experience in this field in one reference text
  • Provides a roadmap for future developments in the area

Readership

Researchers in biochemistry, genetics, biophysics and cancer

Table of Contents

Chapter 1: Introduction

Chapter 2: Physical and chemical basis of non-thermal plasma

2.1: Introduction

2.2: Atmospheric-pressure plasma sources for plasma medicine

2.3: Active laser spectroscopy

2.4: Optical diagnostics of atmospheric pressure plasma

2.5: Electrical diagnostics

2.6: Plasma chemistry of reactive species in gaseous phase 

2.7: Production control of reactive oxygen and nitrogen species in liquid water by using a nonthermal plasma jet

2.8: Reaction of reactive species in cell culture medium

2.9: Simulation of reactive species: kinetics in aqueous phase

Chapter 3: Plasma biological science in various species

3.1: Introduction

3.2: Modelling and analysis of interaction between plasma and living systems

3.3: Effect of plasma irradiation for in vitro growth of Babesia and Trypanosoma parasites

3.4: Intracellular reactive oxygen species (ROS) generation and gene expression changes --- Characteristics of Physical Therapies

3.5: Molecular mechanism of cellular responses to non-thermal plasma

3.6: Plasma medical science through the understanding of biological framework

3.7: Synthetic models to monitor the spatiotemporal delivery of plasma-generated reactive oxygen and nitrogen species into tissue and cells

Chapter 4: Regulation of cell membrane transport by plasma

4.1: Introduction

4.2: Cell membrane transport enhanced by plasma activated channel and transporter

4.3: Cell membrane transport enhanced by plasma-activated endocytosis

4.4: Cell membrane transport via pore formation enhanced by micro-plasma bubble

4.5: Cell membrane transport via pore formation enhanced by plasma reactive species

4.6: Numerical modeling of cell membrane transport enhanced by plasma irradiation

4.7: Future perspective of plasma gene transfection

Chapter 5: Reactive oxygen species in Plasma Medical Science (PAM and cancer therapy)

5.1: Introduction

5.2: Plasma activated medium

5.3: Pathology of oxidative stress

5.4: The translation inhibitor Pdcd4-mediated mechanisms inducing apoptosis and plasma-stimulated cell death

5.5: Plasma medical innovation for cancer therapy

5.6: Plasma medical innovation for cancer therapy: Gynecologic cancers

5.7: Plasma medical innovation for cancer therapy: Glioblastoma

5.8: Plasma medical innovation for cancer therapy: Melanoma

5.9: Plasma medical innovation for cancer therapy: Gastrointestinal cancers

5.10: Plasma medical innovation for cancer therapy: Cancer initiating cells

5.11: Age-related macular degeneration

Chapter 6: Application of plasma to humans (Blood coagulation and regenerative medicine)

6.1: Introduction

6.2: Cutting-edge technologies of bleeding control using non-thermal plasma; Mechanism of blood coagulation and wound healing

6.3: Clinical efficacy of non-thermal plasma treatment in minimally invasive gastrointestinal surgery

6.4: Molecular Morphological Analysis of The Effect of Plasma Irradiation on Cells and Tissue

6.5: Evaluating the invasiveness of non-thermal plasma treatment using molecular imaging technique

6.6: Molecular dissection of biological effects for mouse embryonic stem (mES) cells differentiation treated by low-temperature atmospheric-pressure plasma (APP)

6.7: Cutting-edge studies on the regeneration of neural tissue after plasma treatment

6.8: Innovation in wound care using cold atmospheric plasma technology

6.9: Applying plasma technology to nitric oxide (NO) generation in clinical practices

6.10: Plasma technologies for the development of innovative orthopedic materials

Chapter 7: Safety and standardization toward clinical applications

7.1: Introduction

7.2: General Concepts of Basic Safety on Plasma Treatment

7.3: Application of transgenic mice to analyze genotoxic effects caused by non-thermal atmospheric air plasma

7.4: International standardization: IEC guidelines

7.5: International standardization: CE marking for medical device

Chapter 8: Future outlooks in plasma medical science

Details

No. of pages:
350
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128150047

About the Editor

Shinya Toyokuni

Shinya Toyokuni obtained an MD from Kyoto University, Japan (1985), and a PhD in pathology from Kyoto University (1991). He worked as a postdoctoral fellow in CDRH, Food and Drug Administration, Rockville, MD, USA during 1990-92. He was an instructor, Assistant Professor and Associate Professor in the Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, and since 2008 is Professor in the Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine.

Affiliations and Expertise

Professor, Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan

Masaru Hori

Affiliations and Expertise

Professor, Institute of Innovation for Future Society, Nagoya University, Japan

Yuzuru Ikehara

Affiliations and Expertise

Director, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Japan

Yuzuru Ikehara

Affiliations and Expertise

Director, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Japan

Fumitaka Kikkawa

Affiliations and Expertise

Professor, Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Japan

Fumitaka Kikkawa

Affiliations and Expertise

Professor, Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Japan

Masaru Hori

Affiliations and Expertise

Professor, Institute of Innovation for Future Society, Nagoya University, Japan

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