Plasma Medical Science

Plasma Medical Science

1st Edition - July 6, 2018

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  • Editors: Shinya Toyokuni, Yuzuru Ikehara, Fumitaka Kikkawa, Masaru Hori
  • Paperback ISBN: 9780128150047
  • eBook ISBN: 9780128150054

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Description

Plasma Medical Science describes the progress that has been made in the field over the past five years, illustrating what readers must know to be successful. As non-thermal, atmospheric pressure plasma has been applied for a wide variety of medical fields, including wound healing, blood coagulation, and cancer therapy, this book is a timely resource on the topics discussed.

Key Features

  • Provides a dedicated reference for this emerging topic
  • Discusses the state-of-the-art developments in plasma technology
  • Introduces topics of plasma biophysics and biochemistry that are required to understand the application of the technology for plasma medicine
  • Brings together diverse experience in this field in one reference text
  • Provides a roadmap for future developments in the area

Readership

Researchers in biochemistry, genetics, biophysics and cancer

Table of Contents

  • Chapter 1: Introduction

    Chapter 2: Physical and chemical basis of non-thermal plasma

    2.1: Introduction

    2.2: Atmospheric-pressure plasma sources for plasma medicine

    2.3: Active laser spectroscopy

    2.4: Optical diagnostics of atmospheric pressure plasma

    2.5: Electrical diagnostics

    2.6: Plasma chemistry of reactive species in gaseous phase 

    2.7: Production control of reactive oxygen and nitrogen species in liquid water by using a nonthermal plasma jet

    2.8: Reaction of reactive species in cell culture medium

    2.9: Simulation of reactive species: kinetics in aqueous phase

    Chapter 3: Plasma biological science in various species

    3.1: Introduction

    3.2: Modelling and analysis of interaction between plasma and living systems

    3.3: Effect of plasma irradiation for in vitro growth of Babesia and Trypanosoma parasites

    3.4: Intracellular reactive oxygen species (ROS) generation and gene expression changes --- Characteristics of Physical Therapies

    3.5: Molecular mechanism of cellular responses to non-thermal plasma

    3.6: Plasma medical science through the understanding of biological framework

    3.7: Synthetic models to monitor the spatiotemporal delivery of plasma-generated reactive oxygen and nitrogen species into tissue and cells

    Chapter 4: Regulation of cell membrane transport by plasma

    4.1: Introduction

    4.2: Cell membrane transport enhanced by plasma activated channel and transporter

    4.3: Cell membrane transport enhanced by plasma-activated endocytosis

    4.4: Cell membrane transport via pore formation enhanced by micro-plasma bubble

    4.5: Cell membrane transport via pore formation enhanced by plasma reactive species

    4.6: Numerical modeling of cell membrane transport enhanced by plasma irradiation

    4.7: Future perspective of plasma gene transfection

    Chapter 5: Reactive oxygen species in Plasma Medical Science (PAM and cancer therapy)

    5.1: Introduction

    5.2: Plasma activated medium

    5.3: Pathology of oxidative stress

    5.4: The translation inhibitor Pdcd4-mediated mechanisms inducing apoptosis and plasma-stimulated cell death

    5.5: Plasma medical innovation for cancer therapy

    5.6: Plasma medical innovation for cancer therapy: Gynecologic cancers

    5.7: Plasma medical innovation for cancer therapy: Glioblastoma

    5.8: Plasma medical innovation for cancer therapy: Melanoma

    5.9: Plasma medical innovation for cancer therapy: Gastrointestinal cancers

    5.10: Plasma medical innovation for cancer therapy: Cancer initiating cells

    5.11: Age-related macular degeneration

    Chapter 6: Application of plasma to humans (Blood coagulation and regenerative medicine)

    6.1: Introduction

    6.2: Cutting-edge technologies of bleeding control using non-thermal plasma; Mechanism of blood coagulation and wound healing

    6.3: Clinical efficacy of non-thermal plasma treatment in minimally invasive gastrointestinal surgery

    6.4: Molecular Morphological Analysis of The Effect of Plasma Irradiation on Cells and Tissue

    6.5: Evaluating the invasiveness of non-thermal plasma treatment using molecular imaging technique

    6.6: Molecular dissection of biological effects for mouse embryonic stem (mES) cells differentiation treated by low-temperature atmospheric-pressure plasma (APP)

    6.7: Cutting-edge studies on the regeneration of neural tissue after plasma treatment

    6.8: Innovation in wound care using cold atmospheric plasma technology

    6.9: Applying plasma technology to nitric oxide (NO) generation in clinical practices

    6.10: Plasma technologies for the development of innovative orthopedic materials

    Chapter 7: Safety and standardization toward clinical applications

    7.1: Introduction

    7.2: General Concepts of Basic Safety on Plasma Treatment

    7.3: Application of transgenic mice to analyze genotoxic effects caused by non-thermal atmospheric air plasma

    7.4: International standardization: IEC guidelines

    7.5: International standardization: CE marking for medical device

    Chapter 8: Future outlooks in plasma medical science

Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: July 6, 2018
  • Imprint: Academic Press
  • Paperback ISBN: 9780128150047
  • eBook ISBN: 9780128150054

About the Editors

Shinya Toyokuni

Shinya Toyokuni obtained an MD from Kyoto University, Japan (1985), and a PhD in pathology from Kyoto University (1991). He worked as a postdoctoral fellow in CDRH, Food and Drug Administration, Rockville, MD, USA during 1990-92. He was an instructor, Assistant Professor and Associate Professor in the Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, and since 2008 is Professor in the Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine.

Affiliations and Expertise

Professor, Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan

Yuzuru Ikehara

Affiliations and Expertise

Director, Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Japan

Fumitaka Kikkawa

Affiliations and Expertise

Professor, Department of Obstetrics and Gynaecology, Nagoya University Graduate School of Medicine, Japan

Masaru Hori

Affiliations and Expertise

Professor, Institute of Innovation for Future Society, Nagoya University, Japan

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