Physiology in Sleep

Physiology in Sleep

1st Edition - December 28, 1980

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  • Editor: John Orem
  • eBook ISBN: 9780323154161

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Physiology in Sleep provides the physiological definition of sleep and presents the philosophical approach to sleep that departs from pharmacological and neurophysiological theories of sleep. This book discusses the effects of sleep on cardiovascular and respiratory function, cerebral metabolism and blood flow, as well as temperature regulation. Comprised of eight chapters, this text starts with an overview of the cardiovascular changes that occur during sleep and its direct relevance to human physiology and disease. This book then explores the variety of sleep stages, characteristics, and possible functions. Other chapters consider the evidence of nychtohemeral rhythmicity in man’s hormones that subserve growth, maturation, nurture, reproduction, mineral metabolism, energy regulation, adaptation, and survival. This book further discusses the gastric, esophageal, and intestinal functioning during sleep. The final chapter explores the sleep apnea syndromes and some examples of the sudden infant death syndrome. This book is intended for readers seeking a detailed account of physiology in sleep.

Table of Contents

  • List of Contributors



    1. Cardiovascular Regulation during Sleep

    I. Introduction

    II. Neurophysiological Remarks

    III. Cardiovascular Effects of Sleep

    IV. Autonomic and Nonautonomic Mechanisms Operating during Sleep

    V. Cardiovascular Reflexes during Sleep

    VI. Experimental Hypertension and Sleep

    VII. Cardiovascular Functions in Human Sleep


    2. Sleep and the Cerebral Circulation

    I. Introduction

    II. Regulation of the Cerebral Circulation

    III. CBF during Sleep

    IV. Cerebral Metabolism during Sleep

    V. Summary


    3. Temperature Regulation during Sleep: A Study in Homeostasis

    I. Introduction

    II. Changes in Hypothalamic and Body Temperatures during the Sleep Cycle

    III. Autonomic Temperature Regulation during the Sleep Cycle

    IV. Hypothalamic Unit Activity during the Sleep Cycle

    V. Conclusions


    4 Endocrine Rhythms across Sleep-Wake Cycles in Normal Young Men under Basal State Conditions

    I. Introduction

    II. Hormonal Release Patterns

    III. Purpose of Present Studies

    IV. Basal State: Study Conditions and Methods

    V. Evidence of Nychtohemeral Rhythms in Hormones under Basal State Conditions

    VI. Phase Synchronization of 24-Hour-Long Nychtohemeral Rhythms of Hormones: Comparison of Clocktime, Sleep Onset Time, and Sundown as Basal State Reference Points

    VII. Sleep-Related Masking Effects upon 24-Hour-Long Nychtohemeral Rhythms of Hormones

    VIII. Summary


    5. Hormonal Regulation of Renal Function during Sleep

    I. Introduction

    II. Central Neurotransmitter Regulation of Sleep

    III. Vasopressin (Antidiuretic Hormone)

    IV. Aldosterone

    V. Prolactin

    VI. Parathyroid Hormone

    VII. Catecholamines and Prostaglandins

    VIII. Conclusion


    6. Alimentary Function during Sleep

    I. Introduction

    II. Gastric Function

    III. Esophageal Function

    IV. Intestinal Motility


    7. Breathing in Sleep

    I. Introduction

    II. Spontaneous Changes of Respiration during Sleep

    III. Sleep State and Neural Organization of Respiration

    IV. Responses to Hypercapnia

    V. Responses to Hypoxia

    VI. Upper Airway Reflexes in Sleep

    VII. Lower Airway and Lung Receptor Reflexes in Sleep

    VIII. Lower Airway Function in Sleep

    IX. Conclusion


    8. Control of the Upper Airways during Sleep and the Hypersomnia-Sleep Apnea Syndrome

    I. Introduction

    II. Upper Airway Function during Sleep in Animals and Asymptomatic Humans

    III. Structural Deviations in the Upper Airways

    IV. Active Adduction of the Upper Airways

    V. Sites of Obstruction during Sleep

    VI. The Pathological Link between Airway Obstruction and Sleep

    VII. Apneas in NREM Sleep

    VIII. Apneas in REM Sleep

    IX. A Summary of Mechanisms of Occlusion and Dilation during Arousal and Sleep


    Appendix: A Compendium of Physiology in Sleep

    I. Introduction

    II. Cardiovascular Physiology in Sleep

    III. Cerebral Blood Flow, Intracranial Pressure, and Cerebral Metabolism during Sleep

    IV. Respiration in Sleep

    V. Temperature Regulation in Sleep

    VI. Endocrine Function during Sleep

    VII. Renal Function during Sleep

    VIII. Alimentary Function in Sleep

    IX. Penile Tumescence during Sleep



Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: December 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323154161

About the Editor

John Orem

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