Physiology, Environment, and Man

Physiology, Environment, and Man

Based on a Symposium Conducted by the National Academy of Sciences–National Research Council, August, 1966

1st Edition - January 1, 1970

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  • Editors: Douglas H. K. Lee, David Minard
  • eBook ISBN: 9781483270043

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Description

Physiology, Environment, and Man is based on a symposium conducted by the National Academy of Sciences-National Research Council, August 1966. While one might expect a textbook to present its field in organized and comprehensive fashion, a symposium necessarily follows more of an illustrative pattern, according to the personal interests or even idiosyncrasies of the participants. It is interesting to note that, in spite of these limitations, the presentations did in fact cover the range of physiological concerns with environmental effects, from the genetic to the temporal, and from the molecular to the holistic. The book opens with a discussion of the National Academy of Sciences-National Research Council’s broad-based critical study of the physiological underpinning of current concepts of biological responses to toxic chemicals and physical stresses. Subsequent chapters deal with topics such as the metabolic fate of common environmental agents; growth and trophic factors in carcinogenesis; environmental factors in aging and mortality; adaptation to heat and cold; and the definition of an optimum environment.

Table of Contents


  • Foreword

    The Bretton Woods Symposium: Physiological Characterization of Health Hazards in Man's Environment

    Flow of Environmental Agents in Reaching Their Site of Action

    General Principles of Membrane Penetration

    Penetration of Membranes by Weak Electrolytes

    Absorption from the Gastrointestinal Tract

    Absorption from the Skin

    Absorption from the Respiratory Tract

    Penetration into Red Cells and Platelets

    Penetration into the Central Nervous System

    Liver

    Kidney

    Discussion and Conclusions

    References

    The Metabolic Fate of Common Environmental Agents

    Accumulation of Environmental Agents or Their Effects in the Body

    References

    Interaction of Environmental Agents and Drugs

    References

    Difficulties in Extrapolating the Results of Toxicity Studies in Laboratory Animals to Man

    References

    Some Prospects in Toxicology

    Effects of Environmental Agents at the Genome Level

    Commentary

    Effects of Environmental Agents at the Level of Enzyme-Forming Systems

    Aflatoxins

    Carbon Tetrachloride

    Ethionine

    Conclusion

    References

    Commentary

    Effects of Environmental Agents at the Enzyme Levels—Air Pollutants

    Commentary

    Growth and Trophic Factors in Carcinogenesis

    Spontaneous Regression of Human Cancer

    Dose-Response Relationships in Carcinogenesis

    Two-Stage Theory of Carcinogenesis; Tumor Progression; Dependent and Autonomous Tumors

    Hormonal Factors in Carcinogenesis

    Immunologic Factors in Carcinogenesis

    Nutritional Factors in Carcinogenesis

    General Conclusions

    References

    Commentary

    The Mechanism of Some Structural Alterations of the Lung Caused by Environmental Stresses

    Commentary

    Mechanism of Bronchial Response to Inhalants

    Current Knowledge and Review of Some of the Literature

    State of the Art

    Speculations concerning Implications

    References

    Commentary

    Principles and General Concepts of Adaptation

    Goals of Environmental Physiology

    Criteria of Physiologic Variation

    Molecular Mechanisms of Adaptation

    Application of the Principles to Man

    References

    Human Genetic Adaptation

    Commentary

    Adaptive Cycles

    Environmental Factors in Aging and Mortality

    I. Background and Definitions

    II. Categorical Analysis of Extrinsic Factors Affecting the Rate of Aging

    III. On the Possible Modification of the Rate of Aging through Manipulation of the Internal Environment

    References

    Commentary

    Ecologic and Ethnic Adaptations

    Adaptation to the Physical Environment

    Biologic Factors in the Environment

    Cultural Aspects of the Environment

    Final Remarks

    References

    Commentary

    Ecological Implications of Individuality in the Context of the Concept of Adaptive Strategy

    Commentary

    Cross-Adaptation

    References

    Comments on Cross-Adaptation

    Classification of Adaptations

    Cross-Adaptation

    Methods for Study of Cross-Adaptation or Cross-Acclimation

    References

    Adaptation to Heat and Cold

    Adaptation to Heat

    Adaptation to Cold

    References

    Commentary

    Cardiac Disease in the Context of the Future Environment

    References

    Adaptation and Environmental Control

    Review and Comment on "Waste Management and Control"—a Report to the Federal Council for Science and Technology

    How is an Optimum Environment Defined?

    Culture as Environment

    Physiologic Adaptation

    Enzyme Adaptation to Toxic Hazards

    Enzyme Adaptation to Daily Regimens

    Enzyme Adaptation to Fasting

    Definition of Optimum Environment

    References

    Additional References

    Index

Product details

  • No. of pages: 256
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9781483270043

About the Editors

Douglas H. K. Lee

David Minard

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