1st Edition

Principles and Practice

Authors: Miles Hacker William Messer Kenneth Bachmann
Hardcover ISBN: 9780123695215
eBook ISBN: 9780080919225
Imprint: Academic Press
Published Date: 17th August 2009
Page Count: 608
92.95 + applicable tax
70.95 + applicable tax
56.99 + applicable tax
92.95 + applicable tax
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

Key Features

Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death *Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool


Advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools who want a solid introduction to the basic science of pharmacology and envision careers in drug research

Table of Contents


  1. Routes of Administration
  2. Membranes and Drug Action
  3. Drug Absorption
  4. Drug Transporters in ADME
  5. Drug Distribution
  6. Drug Metabolism
  7. Drug Excretion
  8. Pharmacokinetics
  9. Receptor-ligand Interaction
  10. Molecular Targets for Drug Actions
  11. Cell Signaling Pathways
  12. Immunopharmacology
  13. Drug Toxicity
  14. Adverse Drug Reactions
  15. Cell Death
  16. Pharmacogenomics and Pharmacogenetics
  17. Drug Tolerance, Dependence, Addiction
  18. Drug Resistance
  19. Role of Molecular Biology in Modern Pharmacology
  20. Drug Discovery – Sources of New Drugs
  21. Drug Development – Pre-clinical
  22. Drug Development – Clinical
  23. Nutriceuticals
  24. The FDA


No. of pages:
© Academic Press 2009
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Author

Miles Hacker

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA

William Messer

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA

Kenneth Bachmann

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA