This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

Key Features

*Uses individual drugs to explain molecular actions *Full color art program explains molecular and chemical concepts graphically *Logical structure reflecting the current state of pharmacology and translational research *Covers such intricacies as drug resistance and cell death *Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool


Advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools who want a solid introduction to the basic science of pharmacology and envision careers in drug research

Table of Contents

TABLE OF CONTENTS: 1. Routes of Administration 2. Membranes and Drug Action 3. Drug Absorption 4. Drug Transporters in ADME 5. Drug Distribution 6. Drug Metabolism 7. Drug Excretion 8. Pharmacokinetics 9. Receptor-ligand Interaction 10. Molecular Targets for Drug Actions 11. Cell Signaling Pathways 12. Immunopharmacology 13. Drug Toxicity 14. Adverse Drug Reactions 15. Cell Death 16. Pharmacogenomics and Pharmacogenetics 17. Drug Tolerance, Dependence, Addiction 18. Drug Resistance 19. Role of Molecular Biology in Modern Pharmacology 20. Drug Discovery – Sources of New Drugs 21. Drug Development – Pre-clinical 22. Drug Development – Clinical 23. Nutriceuticals 24. The FDA


No. of pages:
© 2009
Academic Press
eBook ISBN:
Print ISBN:

About the authors

Miles Hacker

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA

William Messer

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA

Kenneth Bachmann

Affiliations and Expertise

The University of Toledo College of Pharmacy, Ohio, USA