Pharmacology of Neuromuscular Function

Pharmacology of Neuromuscular Function

2nd Edition - March 21, 1990

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  • Author: William C. Bowman
  • eBook ISBN: 9781483193564

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Pharmacology of Neuromuscular Function, Second Edition provides information pertinent to drugs that affect membrane potentials of the conduction of action potentials in nerve endings and muscle fibers. This book reviews, in a general way, some of the properties of excitable membranes. Organized into seven chapters, this edition begins with an overview of innervation of striated muscles by somatic efferent nerve fibers. This text then explains the transmission from nerve to muscle, which is mediated by acetylcholine that is synthesized and stored in the axon terminals. Other chapters consider the different steps in the transmission process that occur in the nerve endings, which may be modified by the actions of drugs and toxins. This book discusses as well the primary action of neuromuscular-blocking agents. The final chapter deals with the cytoplasm of a muscle cell or fiber that contains all the usual subcellular organelles, including mitochondria and nuclei. This book is a valuable resource for pharmacologists and anesthetists.

Table of Contents

  • Preface

    1 Striated Muscle

    Innervation of Striated Muscle

    Different Types of Muscle Fibers

    2 Excitable Membranes

    Properties of Excitable Membranes

    Some Membrane-Active Drugs and Toxins

    3 Neuromuscular Transmission: Prejunctional Events


    Acetylcholine Synthesis

    Acetylcholine Storage

    Acetylcholine Release

    4 Pharmacological Manipulation of Prejunctional Events


    Inhibition of Acetylcholine Synthesis

    Drugs That Inhibit Vesicular Loading: Vesamicol and Tetraphenylboron

    Agents and Factors That Modify Acetylcholine Release

    Nicotinic and Muscarinic Receptors on the Nerve Endings

    5 Neuromuscular Transmission: Postjunctional Events

    Development of the Receptor Concept

    Postjunctional Acetylcholine Receptors

    Receptor Function

    The Endplate Response

    Summary of Postjunctional Events

    Receptor Desensitization

    Acetylcholine Receptors of Denervated Muscle

    Receptors in Myasthenia Gravis

    Termination of Acetylcholine Action: Acetylcholinesterase

    Anticholinesterase Drugs

    6 Neuromuscular-Blocking Agents


    Non-Depolarizing Acetylcholine Antagonists

    Curarizing Agents from Natural Sources

    Mechanism of Action of Tubocurarine

    Characteristics of Block Produced by Tubocurarine

    The Basis of Clinical Monitoring

    Structure-Action Relations

    Clinically Used Non-Depolarizing Neuromuscular-Blocking Drugs


    Interactions between Two Non-Depolarizing Neuromuscular-Blocking Drugs

    'The Priming Principle'

    Unwanted Effects

    Unwanted Drug Interactions Involving Neuromuscular-Blocking Agents

    Reversal Agents

    Some Potential New Non-Depolarizing Neuromuscular-Blocking Agents

    Depolarizing Blocking Drugs

    Variations in Depolarization Block

    Multiply Innervated Muscle Fibers

    Succinyldicholine (Suxamethonium)

    7 Muscle Contraction

    Fiber Structure


    Drugs Affecting Muscle Contractility



Product details

  • No. of pages: 326
  • Language: English
  • Copyright: © Butterworth-Heinemann 1990
  • Published: March 21, 1990
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483193564

About the Author

William C. Bowman

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