Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

1st Edition - August 1, 2022

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  • Editor: Hiroshi Yamazaki
  • Hardcover ISBN: 9780323911092

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Description

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.

Key Features

  • Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology
  • Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans
  • Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450

Readership

A variety of pharmacologists and toxicologists

Table of Contents

  • Preface
    Hiroshi Yamazaki
    1. Multiple conformations of cytochromes P450 & the relevance to predicting SAR
    F. Peter Guengerich
    2. Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism
    Ann Daly
    3. Cytochromes P450 drug metabolism within the brain
    Rachel F. Tyndale
    4. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences
    M. Denise Dearing
    5. Atypical kinetics of cytochrome P450 enzymes in drug metabolism
    Eric Chun Yong Chan
    6. Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites
    W. Griffith Humphreys
    7. Use of engineered cytochrome P450s for accelerating drug discovery and development
    Elizabeth Gillam
    8. Assessing cytochrome P450 function using genetically engineered mouse models
    Xinxin Ding
    9. Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions
    Christophe Chesné
    10. Cytochromes P450 in chimeric mice with humanized liver
    Shotaro Uehara
    11. Polymorphic cytochromes P450 in non-human primates
    Yasuhiro Uno
    12. Cytochromes P450 in pediatrics (and elder people)
    Chie Emoto
    13. Pre-emptive cytochromes P450 genotyping for better pharmacotherapy
    Magnus Ingelman-Sundberg

Product details

  • No. of pages: 312
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323911092

About the Serial Volume Editor

Hiroshi Yamazaki

Hiroshi Yamazaki
Hiroshi Yamazaki has been Professor of the Laboratory of Drug Metabolism and Pharmacokinetics at Showa Pharmaceutical University, Tokyo, Japan since 2005. After receiving his BS and MS degrees from Gifu Pharmaceutical University and a PhD in Pharmaceutical Sciences from Osaka University in Japan, he trained as a post-doctoral fellow at Vanderbilt University School of Medicine, Nashville, TN, USA in 1994. He was recruited as an Associate Professor at Kanazawa University from Osaka Prefectural Institute of Public Health in 1998 and then an Associate Professor at Hokkaido University Graduate School of Pharmaceutical Sciences in 2001. Professor Yamazaki’s research has focused on cytochromes P450, flavin-containing monooxygenases, and simple pharmacokinetic modeling. His P450 papers cover a broad range of topics. He has authored over 500 original publications (http://orcid.org/0000-0002-1068-4261) with an h-index of 66 in Scopus (Author ID: 557193405959) . Professor Yamazaki is a member of several professional societies and editorial committees and was designated as one of the experts of Chemical Substance Assessment Groups (of the Food and Safety Commission of Japan, 2006-15). He is a recipient of the Japanese Society for the Study of Xenobiotics (JSSX) Award and Fellowship and was ex-JSSX President (2017-19) and Editor-in-Chief of Drug Metabolism and Pharmacokinetics (2014-17). Professor Yamazaki was the leading organizer of 19th International Conference on Cytochrome P450, in Tokyo, Japan in 2015.

Affiliations and Expertise

Showa Pharmaceutical University, Tokyo, Japan

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