1st Edition - June 4, 2019

Write a review

  • Editor: Ramón Cacabelos
  • Hardcover ISBN: 9780128139394
  • eBook ISBN: 9780128139400

Purchase options

Purchase options
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.

Key Features

  • Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development
  • Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry
  • Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety
  • Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine


Translational researchers, clinicians and graduate students in genomic medicine, epigenetics; life science researchers; developmental biologists; MDs/clinicians; pharmacologists in industry and academia; cardiologists, psychiatrists, oncologists, hospitalists, primary care doctors, neurologists, immunologists, medical chemists, molecular biologists

Table of Contents

  • 1. The Epigenetic Machinery in the Life Cycle and Pharmacoepigenetics
    2. Pharmacoepigenetics: Basic Principles for Personalized Medicine
    3. Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport
    4. MicroRNA-Dependent Gene Regulation of the Human Cytochromes P450
    5. Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis
    6. Pharmacoepigenetic Processors: Epigenetic Drugs, Drug Resistance, Toxicoepigenetics, and Nutriepigenetics
    7. Pharmacoepigenetics of Novel Nucleoside DNA Methyltransferase Inhibitors
    8. Pharmacoepigenetics: Novel Mechanistic Insights in Drug Discovery and Development Targeting Chromatin-Modifying Enzymes
    9. Pharmacoepigenetics of EZH2 Inhibitors
    10. Regulators of Histone Acetylation: Bromodomain Inhibitors
    11. Bromodomain Inhibition and Its Application to Human Disease
    12. Epigenetic Drug Discovery for Cancer
    13. Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer
    14. Pharmacoepigenetics of LSD1 Inhibitors in Cancer
    15. Pharmacoepigenetic Considerations for the Treatment of Breast Cancer
    16. Pharmacoepigenetics of Acute Myeloid Leukemia
    17. Therapeutic Potential of Pharmacoepigenetics in Cholangiocarcinoma
    18. Pharmacoepigenetics in Type 2 Diabetes Mellitus
    19. Pharmacoepigenetics of Immunological Disorders
    20. Pharmacoepigenetics of Rheumatic Disorders
    21. Pharmacoepigenetics of Systemic Lupus Erythematosus
    22. Epigenetics and Pharmacoepigenetics of Neurodevelopmental and Neuropsychiatric Disorders
    23. Pharmacoepigenetics and Toxicoepigenetics in Neurodevelopmental Disorders
    24. Pharmacoepigenetics of Autism Spectrum Disorder
    25. Pharmacoepigenetics of Antipsychotic Drugs
    26. Pharmacoepigenetics of Bipolar Disorder
    27. Pharmacoepigenetics of Major Depression
    28. Pharmacoepigenetics of Vertigo and Related Vestibular Syndromes
    29. Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity
    30. Pharmacoepigenetics and Pharmacoepigenomics of Valproate in Neurodegenerative Disease
    31. Pharmacoepigenetics of Statins
    32. Pharmacoepigenetics of Memantine in Dementia
    33. Epigenetics in Doxorubicin Cardiotoxicity
    34. Pharmacoepigenetics of Brassica-Derived Compounds
    35. Pharmacoepigenetics of Chinese Herbal Components in Cancer
    36. Epigenetics of Aging and Age-Related Disorders
    37. Epigenetics of Aging and Cancer: A Comprehensive Look
    38. Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders

Product details

  • No. of pages: 983
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: June 4, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128139394
  • eBook ISBN: 9780128139400

About the Editor

Ramón Cacabelos

Dr. Ramón Cacabelos is Professor and Chairman of Genomic Medicine and President of the EuroEspes Biomedical Research Center, Corunna, Spain. He received his M.D. from Oviedo University, Oviedo, Spain; Ph.D. from Santiago University, Santiago de Compostela, Spain; and D.M.Sci. (Psychiatry) from Osaka University Medical School, Osaka, Japan. After a decade at the Department of Psychiatry in Osaka, he returned to Spain and focused his research activity on the genomics, epigenomics and pharmacogenomics of brain disorders, with special emphasis on neurodegenerative disorders (Alzheimer’s disease, Parkinson’s disease). He has published over 700 papers and 30 books and is Editor-in-Chief of the first World Guide for Drug Use and Pharmacogenomics and President of the World Association of Genomic Medicine.

Affiliations and Expertise

Professor of Genomic Medicine, Visiting Professor of Health Science, Aino University, Osaka, Japan, President, World Association of Genomic Medicine, President, Spanish Society of Genomic Medicine

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • MeriemHamza Tue Oct 01 2019