Pertussis Toxin - 1st Edition - ISBN: 9780126354805, 9780323158480

Pertussis Toxin

1st Edition

Editors: Ronald Sekura
eBook ISBN: 9780323158480
Imprint: Academic Press
Published Date: 1st January 1985
Page Count: 268
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Pertussis Toxin presents the proceeding of the Pertussis Toxin Conference, held in Bethesda, Maryland, on September 20–21, 1984. This book discusses the perspective of the pertussis toxin and the potential role of the toxin in the development of new acellular pertussis vaccines. Organized into 13 chapters, this text begins with an overview of the biological activities of pertussis vaccine, which enhanced the production of antibodies to antigens. This book then examines the interesting action of pertussis vaccine to stimulate antibody production, particularly as an effective adjuvant for the production of IgE isotype of antibodies. Other chapters consider the experimental approaches used in the study of the mechanisms by which hormones produce their physiological effect. The final chapter examines the several features of the Bordetella adenylate cyclase toxin, which suggest that the molecule may follow the A/B model proposed for a number of bacterial toxins. This book is a valuable resource for toxicologists, immunologists, bacteriologists, and pharmacologists.

Table of Contents



Biological Activities of Pertussigen (Pertussis Toxin)

Islet-Activating Protein, Pertussis Toxin: Subunit Structure and Mechanism for Its Multiple Biological Actions

Pertussis Toxin: Structural Elements Involved in the Interaction with Cells

GTP-Regulatory Proteins Are Intracellular Messagers: A Model for Hormone Action

Structural and Functional Properties of N8 and Ni: The Regulatory Components of Adenylyl Cyclases

Pertussis Toxin-Catalyzed ADP-Ribosylation: Effects on Coupling of Inhibitory Receptors to Adenylate Cyclase

Resolution of Agonists and Gpp(NH)p Mediated Adenylate Cyclase Inhibition with Pertussis Toxin

Pertussis Toxin Discriminates Somatostatin's Regulation of ACTH Release through Adenylate Cyclase and Non-Adenylate Cyclase Mechanisms

Genetic and Functional Studies of Pertussis Toxin Subtrates

Biochemical Basis of the Adjuvant Effects of Pertussis Toxin for the IgE Response

Effect of Pertussis Toxin on the Hormonal Responsiveness of Different Tissues

Extracellular Adenylate Cyclase of Bordetella pertussis

Bordetella Adenylkate Cyclase Toxin: Its Intoxication of Mammalian Cells and Effects on Cell Function



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© Academic Press 1985
Academic Press
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About the Editor

Ronald Sekura

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