This readable, comprehensive text covers endothelial biology from the fundamentals of structure and lung fluid balance physiology to state-of-the-art descriptions of the molecular mechanisms involved in the development of lung failure. The material and illustrations, provided by outstanding experts in their individual areas of research and clinical concentration, is artfully woven together to provide the reader with an integrated, in-depth, and up-to-date knowledge of endothelial function, vascular integrity, pulmonary function, and pathophysiology in respiratory failure.


Cell biologists researching vascular biology.

Table of Contents

The cellular and molecular foundations of pulmonary edema; Molecular architecture of endothelium; The activated endothelial cell phenotypes; Membrane and cellular signaling of integrity and acute activation; Adenylyl cyclase and camp regulation of the endothelial barrier; Signaling of prolonged activation; Dynamic microfilaments and microtubules regulate endothelial function; Endothelial-matrix interactions in the lung; Interendothelial junctions and barrier integrity; Heterogeneity of lung endothelial cells; Interaction of endothelial cells with blood elements; Endothelial cell injury and defense; Endothelial injury due to infectious agents; Chronic lung vascular hyperpermeability; Advances in protection of endothelial barrier function; Looking to the future as keepers of the dam.


No. of pages:
© 2005
Elsevier Science
Print ISBN:
Electronic ISBN:

About the editor

C.E. Patterson

Affiliations and Expertise

Indiana University School of Medicine & Roudebush VA Medical Center, Indianapolis, IN, USA