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Peripheral Dopaminergic Receptors - 1st Edition - ISBN: 9780080231891, 9781483156163

Peripheral Dopaminergic Receptors

1st Edition

Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Strasbourg, 24-25 July 1978

Editors: Jean Louis Jean Schwartz
eBook ISBN: 9781483156163
Imprint: Pergamon
Published Date: 26th June 1979
Page Count: 420
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Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents


Introductory Lecture

The Dopamine Vascular Receptor: Agonists and Antagonists

Dopamine Measurement

Free and Conjugated Dopamine: Physiological and Clinical Implications

Tissue Dopamine Levels as an Indicator of Tyrosine Hydroxylase Activity

A Mass Fragmentographic Assay of Human Plasma Catecholamines

Histochemical and Biochemical Estimations of Dopamine in Postganglionic Autonomic Nerves


Structure — Activity Relationship

Structure-Activity and Conformational Requirements for Dopaminergic Agonists: Comparison of Central and Peripheral Dopamine Receptors

Structure-Activity Relationships at Dopaminergic Receptors

Dopamine Congeners derived from the Benzo(f)-Quinoline Ring

Dopamine 3-0-Sulfate, a Direct Precursor of Free Norepinephrine: an Alternative Biosynthetic Pathway

Dopamine-Sensitive Adenylate Cyclase in Canine Renal Artery


Peripheral Actions of Dopamine (except Kidney)

Dopamine and Chronic Auriculo-Ventricular Heart-Block in the Unanaesthetized Dog


α-and ß-adrenoceptors, But Not Dopaminergic Receptors are Involved in the Positive Inotropic Action of Dopamine in the Rabbit Heart


Dopamine-induced Relaxation of Isolated Dog Arteries

In Vitro Study with Semi-rigid Rotameric Conformational Analogs of Dopamine

Effects of Several Central Dopamine Receptor Stimulants on Mesenteric Arterial Blood Flow in Anesthetized Dogs

Vasodilatation produced by Apomorphine in the Hindleg of the Dog


Dopaminergic Receptors in the Coronary Arteries

Concentration and Function of Dopamine in Normal and Diseased Blood Vessels

Possible Involvement of Endogenous Substances in the Cardiovascular Actions of Dopamine


Species Differences of Dopaminergic Vasodilation in the Intestine

Search for a Serotoninergic Mechanism in the Pharmacological Effects of Dopamine on Motricity in the Isolated Rat Duodenum

Effects of Dopamine on the Cerebral Circulation


Dopamine and Autonomic Nervous System

Physiological and Pharmacological Role of the Regulation of Noradrenaline Release by Presynaptic Dopamine Receptors in the Peripheral Nervous System


The Inhibitory Neurogenic Effects of N-N-di-n-Propyl Dopamine: a Vascular Dopamine Agonist

Action of Piribedil on Presynaptic Dopamine Receptors at Postganglionic Sympathetic Nerve Terminals


Characteristics of Apomorphine Tachyphylaxis


Inhibitory Receptors on the Adrenergic Nerve Terminal


The Role of a Ca++-Dependent Protein Activator purified from Brain in the Regulation of Dopamine Receptors


Evidence that Dopamine Receptors mediate the Neurogenic Vasodilatation by Dopaminergic Agents


Role of Dopamine in the Modulation of Norepinephrine Release from the Rat Portal Vein

Selective Prevention of a Bethanechol-Induced Decrements of Histofluorescence in Sympathetic Ganglia


Dopamine and the Kidney

Renal Dopaminergic Mechanisms


Effect of Dopamine on Renin Release from the Isolated Perfused Rat Kidney


Renal and Adrenal Dopamine Balance: Implications for the Role of Conjugated Dopamine


L-γ-Glutamyl Dopamine, an Oral Dopamine Prodrug with Renal Selectivity

Regulation of Renal Function by Endogenous Dopamine


Studies on the Peripheral Cardiovascular Activity of Dopamine in the Rat


Concluding Remarks



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© Pergamon 1979
26th June 1979
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About the Editors

Jean Louis

Jean Schwartz

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