Peripheral Dopaminergic Receptors

Peripheral Dopaminergic Receptors

Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Strasbourg, 24-25 July 1978

1st Edition - June 26, 1979

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  • Editors: Jean Louis, Jean Schwartz
  • eBook ISBN: 9781483156163

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Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents

  • Preface

    Introductory Lecture

    The Dopamine Vascular Receptor: Agonists and Antagonists

    Dopamine Measurement

    Free and Conjugated Dopamine: Physiological and Clinical Implications

    Tissue Dopamine Levels as an Indicator of Tyrosine Hydroxylase Activity

    A Mass Fragmentographic Assay of Human Plasma Catecholamines

    Histochemical and Biochemical Estimations of Dopamine in Postganglionic Autonomic Nerves


    Structure — Activity Relationship

    Structure-Activity and Conformational Requirements for Dopaminergic Agonists: Comparison of Central and Peripheral Dopamine Receptors

    Structure-Activity Relationships at Dopaminergic Receptors

    Dopamine Congeners derived from the Benzo(f)-Quinoline Ring

    Dopamine 3-0-Sulfate, a Direct Precursor of Free Norepinephrine: an Alternative Biosynthetic Pathway

    Dopamine-Sensitive Adenylate Cyclase in Canine Renal Artery


    Peripheral Actions of Dopamine (except Kidney)

    Dopamine and Chronic Auriculo-Ventricular Heart-Block in the Unanaesthetized Dog


    α-and ß-adrenoceptors, But Not Dopaminergic Receptors are Involved in the Positive Inotropic Action of Dopamine in the Rabbit Heart


    Dopamine-induced Relaxation of Isolated Dog Arteries

    In Vitro Study with Semi-rigid Rotameric Conformational Analogs of Dopamine

    Effects of Several Central Dopamine Receptor Stimulants on Mesenteric Arterial Blood Flow in Anesthetized Dogs

    Vasodilatation produced by Apomorphine in the Hindleg of the Dog


    Dopaminergic Receptors in the Coronary Arteries

    Concentration and Function of Dopamine in Normal and Diseased Blood Vessels

    Possible Involvement of Endogenous Substances in the Cardiovascular Actions of Dopamine


    Species Differences of Dopaminergic Vasodilation in the Intestine

    Search for a Serotoninergic Mechanism in the Pharmacological Effects of Dopamine on Motricity in the Isolated Rat Duodenum

    Effects of Dopamine on the Cerebral Circulation


    Dopamine and Autonomic Nervous System

    Physiological and Pharmacological Role of the Regulation of Noradrenaline Release by Presynaptic Dopamine Receptors in the Peripheral Nervous System


    The Inhibitory Neurogenic Effects of N-N-di-n-Propyl Dopamine: a Vascular Dopamine Agonist

    Action of Piribedil on Presynaptic Dopamine Receptors at Postganglionic Sympathetic Nerve Terminals


    Characteristics of Apomorphine Tachyphylaxis


    Inhibitory Receptors on the Adrenergic Nerve Terminal


    The Role of a Ca++-Dependent Protein Activator purified from Brain in the Regulation of Dopamine Receptors


    Evidence that Dopamine Receptors mediate the Neurogenic Vasodilatation by Dopaminergic Agents


    Role of Dopamine in the Modulation of Norepinephrine Release from the Rat Portal Vein

    Selective Prevention of a Bethanechol-Induced Decrements of Histofluorescence in Sympathetic Ganglia


    Dopamine and the Kidney

    Renal Dopaminergic Mechanisms


    Effect of Dopamine on Renin Release from the Isolated Perfused Rat Kidney


    Renal and Adrenal Dopamine Balance: Implications for the Role of Conjugated Dopamine


    L-γ-Glutamyl Dopamine, an Oral Dopamine Prodrug with Renal Selectivity

    Regulation of Renal Function by Endogenous Dopamine


    Studies on the Peripheral Cardiovascular Activity of Dopamine in the Rat


    Concluding Remarks


Product details

  • No. of pages: 420
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: June 26, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483156163

About the Editors

Jean Louis

Jean Schwartz

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