Pathophysiology, Pharmacology and Biochemistry of Dyskinesia, Volume 98

1st Edition

Serial Volume Editors: Jonathan Brotchie Erwan Bezard Peter Jenner
Hardcover ISBN: 9780123813282
eBook ISBN: 9780123813299
Imprint: Academic Press
Published Date: 19th September 2011
Page Count: 664
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Table of Contents



An Introduction to Dyskinesia—The Clinical Spectrum

I Introduction

II Akathisia

III Ballism

IV Chorea

V Dystonia

VI Jumpy Stumps

VII Levodopa-Induced Dyskinesias

VIII Assessment of Dyskinesia

IX Moving Toes and Moving Fingers

X Myoclonus

XI Myokymia

XII Myorhythmia

XIII Stereotypy

XIV Tardive dyskinesia

XV Tics

XVI Tremor

XVII Conclusion

L-Dopa-Induced Dyskinesia—Clinical Presentation, Genetics, and Treatment

I Introduction

II Historical Aspects

III Epidemiology

IV Risk Factors

V Genetics of Dyskinesia

VI Classification

VII Clinical Characteristics

VIII Treatment

Experimental Models of L-DOPA-Induced Dyskinesia

I Historical Development of a Model of L-DOPA-Induced Dyskinesia

II MPTP-Lesioned Primate Model of L-DOPA-Induced Dyskinesia

III Unilateral 6-OHDA Lesioned Rodent Model of L-DOPA-Induced Dyskinesia

IV Critique of Toxin-Based Models of L-DOPA-Induced Dyskinesia

V Alternative Models of L-DOPA-Induced Dyskinesia

VI Future Modeling of L-DOPA-Induced Dyskinesia

VII Conclusions

Molecular Mechanisms of L-DOPA-Induced Dyskinesia

I Introduction

II Basal Ganglia and Medium Spiny Neurons

III LID and Hyperactivity of D1R/cAMP Signaling

IV Increased ERK Signaling in LID: Transcriptional and Translational Changes

V Glutamate NMDA Receptors and LID

VI mGluR5

VII Controlling Dyskinesia by Acting on the MSNs of the Indirect Pathway

VIII Cannabinoid CB1 Receptors

IX Pre-Synaptic Mechanisms: Serotonin Receptors

X Conclusions

New Approaches to Therapy

I Introduction

II Factors that Control the Priming and Expression of LID

III Modifying LID Through Dopami


Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.

Key Features

  • Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


Neuroscientists, neurologists, psychologists


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© Academic Press 2011
Academic Press
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"Invaluable reading." - NATURE
"A valuable addition to any library as current reference material for advanced undergraduates, graduate students, and professional scientists."

About the Serial Volume Editors

Jonathan Brotchie Serial Volume Editor

Erwan Bezard Serial Volume Editor

Peter Jenner Serial Volume Editor

Affiliations and Expertise

King's College, London, U.K. Head of Pharmacology and Therapeutics Division