Pathologic Basis of Veterinary Disease

Pathologic Basis of Veterinary Disease

7th Edition - December 15, 2021

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  • Author: James Zachary
  • eBook ISBN: 9780323713146
  • Hardcover ISBN: 9780323713139

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Description

Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices.

Key Features

  • Clear, up-to-date illustrations and explanations of the macroscopic (gross) and microscopic lesions resulting from diseases occurring in domestic animals
  • Complete coverage of both general pathology and the pathology of organ systems that includes the latest research, practice, and diagnostic information on disease mechanisms, pathogenesis, and lesions.
  • Clear explanations of disease mechanisms that describe cell, tissue, and organ system responses to injury and infection.
  • Easy-to-follow organization for each systemic disease chapter including a brief review of the study of diseases that occur in specific tissues, organs, and organ systems, with basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping students apply principles to veterinary practice.
  • More than 2,100 full-color illustrations featuring color photographs, schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts.
  • Content on cellular and organ system pathology updated throughout the book, with expanded coverage of genetics and disease.
  • Key Readings Index in each chapter with page numbers for key topics.
  • Essential Concept boxes in each General Pathology chapter break down complicated topics that are critical to understanding lesions and pathogeneses.
  • More than 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathologists’ board examination.
  • An enhanced eBook is included with new print purchase, featuring the complete, fully searchable text plus an image collection; the text, tables, and boxes linked to the website that are cited throughout the book; ten new appendices that focus on veterinary diagnostic pathology, postmortem examination, interpretation of lesions, and more; plus an established appendix of photographic techniques used in veterinary diagnostic pathology.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Introduction. Fundamentals for Understanding Veterinary Pathology
  • Information Fundamental for Effective Use of this Book
  • In Conclusion
  • Section I. Cellular and Molecular Mechanisms of Disease (General Pathology)
  • Introduction
  • Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Death
  • Introduction
  • Normal Cell
  • Causes of Cell Injury
  • Irreversible Cell Injury and Cell Death
  • Chronic Cell Injury and Cell Adaptations
  • Cell Cycle
  • Cellular Aging
  • Genetic Basis of Disease
  • Chapter 2. Vascular Disorders and Thrombosis
  • Introduction
  • Circulatory System
  • Microcirculation, Interstitium, and Cells
  • Fluid Distribution and Homeostasis
  • Abnormal Fluid Distribution
  • Hemostasis
  • Disorders of Hemostasis: Hemorrhage and Thrombosis
  • Normal Blood Flow, Distribution, and Perfusion
  • Alterations in Blood Flow and Perfusion
  • Shock
  • Chapter 3. Inflammation and Healing
  • Introduction
  • Evolution of the Current Understanding of Inflammation
  • Beneficial and Harmful Aspects of Inflammation
  • Acute Inflammation
  • Substances Inducing the Acute Inflammatory Response
  • Fluidic (Exudative) Phase of the Acute Inflammatory Response
  • Cellular Phase of the Acute Inflammatory Response
  • Additional Regulation of Inflammation
  • Inflammation and Pain
  • Effector Cells of the Acute Inflammatory Response
  • Chemical Mediators of the Acute Inflammatory Response
  • Reparative Phase of the Acute Inflammatory Response
  • Nomenclature of the Inflammatory Response (Morphologic Diagnoses)
  • Morphologic Classification of Exudates in Acute Inflammatory Lesions
  • Chronic Inflammation
  • Beneficial and Harmful Aspects of Chronic Inflammation
  • Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation
  • Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response
  • Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses
  • Inflammation and the Sensation of Pain
  • The Effect of Inflammation on the Febrile Response and Other Activities
  • Unique Types of Inflammation
  • Cytologic and Histologic Comparisons of Inflammatory Exudates
  • Wound Healing and Angiogenesis
  • Chapter 4. Mechanisms of Microbial Infections
  • Introduction
  • Chronologic Sequence of Steps in Microbial Diseases
  • Portals of Entry
  • Target Cells and Substances
  • Pathways of Spread
  • Defense Mechanisms
  • Genetic Resistance of Animals to Infectious Diseases
  • Bacterial Diseases
  • Viral Diseases
  • Fungal Diseases (Mycoses)
  • Protozoan Diseases
  • Prion Diseases (Spongiform Encephalopathies)
  • Chapter 5. Diseases of Immunity
  • General Features of the Immune System
  • Innate Immunity (Nonspecific Immunity)
  • Adaptive Immunity (Specific Immunity)
  • Disorders of the Immune System
  • Chapter 6. Neoplasia and Tumor Biology
  • Introduction
  • General Nomenclature
  • Tumor Characteristics (Essential Concept 6.1)
  • Neoplastic Transformation (Essential Concept 6.2)
  • Tumor Microenvironment (Essential Concept 6.3)
  • Tumor Immunity (see Essential Concept 6.3)
  • Tumor Dissemination (Essential Concept 6.4)
  • Systemic Clinical Effects on the Animal (see Essential Concept 6.3)
  • Heritable Alterations in Cancer (Essential Concept 6.5)
  • Molecular Determinants of Cancer
  • Mechanisms of Carcinogenesis
  • Cancer in Animals
  • Section II. Pathology of Organ Systems
  • Introduction
  • Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity
  • Introduction
  • Structure and Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animalsc,d
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 8. Hepatobiliary System and Exocrine Pancreas
  • Liver and Intrahepatic Biliary System
  • Gallbladder and Extrahepatic Bile Ducts
  • Exocrine Pancreas
  • Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae
  • Introduction
  • Structure and Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vessels
  • Structure
  • Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 11. The Urinary System
  • Kidney
  • Lower Urinary Tract
  • Chapter 12. Endocrine System
  • Structure and Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System
  • Introduction
  • Bone Marrow and Blood Cells
  • Chapter 14. Nervous System
  • The Nervous System
  • Central Nervous System
  • Peripheral Nervous System
  • Chapter 15. Skeletal Muscle
  • Structure
  • Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 16. Bones, Joints, Tendons, and Ligaments
  • Introduction
  • Structure and Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter17. The Integument
  • Structure
  • Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • E-Appendix 17.1. Postmortem Evaluation of the Skin, Claws, Pawpads, and Hooves
  • Chapter 18. Female Reproductive System and Mammae
  • Introduction
  • E-Appendix 18.1 Techniques Used to Examine the Female Reproductive System and Mammae
  • Structure
  • Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 19. Male Reproductive System
  • E-Appendix 19.1 Methods for Examining the Male Reproductive Tract
  • Introduction
  • Structure
  • Function
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 20. The Ear
  • Introduction
  • Structure and Function
  • E-Appendix 20.1. Histologic Evaluation of the Internal Ear
  • Dysfunction/Responses to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • Chapter 21. The Eye
  • Introduction
  • Structure and Function
  • Dysfunction/Response to Injury
  • Portals of Entry/Pathways of Spread
  • Defense Mechanisms/Barrier Systems
  • Diseases Affecting Multiple Species of Domestic Animals
  • Diseases of Horses
  • Diseases of Ruminants (Cattle, Sheep, and Goats)
  • Diseases of Pigs
  • Diseases of Dogs
  • Diseases of Cats
  • E-Appendix 21.1 Postmortem Technique
  • Section III: Appendices, Veterinary Diagnostic Pathology
  • Introduction
  • Appendix A. Communication, Collaboration, and Consultation in Veterinary Pathology
  • Appendix B. Photographic Techniques in Veterinary Pathology
  • Appendix C. Postmortem Examination (Autopsy) of Domestic Animal Species
  • Appendix D. Recognition and Interpretation of Macroscopic (Gross) Lesions
  • Appendix E. Diagnoses in Veterinary Pathology
  • Appendix F. General Principles of Tissue Fixation and Processing
  • Appendix G. Fixatives and Fixation
  • Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves
  • Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning Artifacts
  • Appendix J. Gross Examination and Infusion Fixation of the Lung
  • Appendix K. Necropsy Techniques by Organ System
  • Index

Product details

  • No. of pages: 1528
  • Language: English
  • Copyright: © Mosby 2021
  • Published: December 15, 2021
  • Imprint: Mosby
  • eBook ISBN: 9780323713146
  • Hardcover ISBN: 9780323713139

About the Author

James Zachary

Affiliations and Expertise

Diplomate, American Colllege of Veterinary Pathologists; Professor of Veterinary Pathology, Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL

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