Pathogenesis of Leprosy and Related Diseases

Pathogenesis of Leprosy and Related Diseases provides insights into the pathology of granulomatous conditions. The book discusses topics on the factors that induce immunosuppression; immunohistological spectra of granulomatous diseases; study of cutaneous leishmaniasis; and the validity of histopathological analysis. Pathologists, immunologists, experimentalists, and researchers in the medical field will find the book interesting.

Contents

Foreword

Preface

Abbreviations

1 Introduction

The Study of Pathogenesis

The Calibration of A Histopathological Picture

Part I General Considerations

2 The Structure of Skin

The Skin Biopsy

The Normal Skin

3 The Structure of Peripheral Nerve

Microanatomy

Response To Disease

4 Inflammation

Inflammatory Cells

Acute and Chronic Inflammation

Granuloma Formation

Necrosis and Fibrosis

Immune Complexes and Inflammation

5 Concepts of the Spectrum

Part II Leprosy

6 The Leprosy Bacillus

Growth Characteristics

Morphology and Constitution

7 The Disease Called Leprosy

Introduction

The Pathogenesis of the Clinical Picture

Immunology

8 The Early Skin Lesion of Leprosy

The Evolution of the Lesion

Protected and Optimal Sites

The Portal of Entry

9 Neuropathy in Leprosy

The Pathway of Nerve Involvement

The Neuropathology of Leprosy

The Pathogenesis of the Lesion

Neural Affinity, Immunological Protection and Autoimmunity

10 Leprosy As A Systemic Disease

Respiratory Tract

Vascular Disease

Reticuloendothelial System

Other Organs and Tissues

11 Nature of the Leprosy Spectrum

Basis of the Ridley-Jopling Classification

Immunopathology of the Spectrum

Evolution of the Response

12 Activity of the Infection

Phases of Bacterial Multiplication

The Macrophage Cycle

Viable and Dead Bacilli

Reactivity and Relapse

13 Reactions

Type 1 (Borderline) Reactions

Erythema Nodosum Leprosum

Exacerbation Reactions

14 The Defect in Leprosy

Epidemiological Considerations

Genetic Inheritance

Portal of Entry

The Evolution of the Response

Immunosuppression

15 Histological Diagnosis

Principles of Diagnosis

Early Lesions

Tuberculoid Lesions

Differentiation of Reaction and Relapse

16 Classification

Histological Classification in Skin

Histological Classification in Nerve

Part III Related Diseases

17 Leishmania and Leishmaniasis

Speciation and Form of Disease

The Spectrum of Cutaneous Leishmaniasis

18 Leishmaniasis: The Tissue Response

Onset of Infection

General Pathology of Cutaneous Leishmaniasis

Alternative Modes of Evolution

Mucocutaneous Leishmaniasis

Visceral Leishmaniasis

19 Leishmaniasis: Pathogenesis

Initiation of the Infection

Mechanisms of Parasite Elimination

Immunosuppression

20 Tuberculosis and Its Pathology

The Tubercle Bacillus

General Pathology

The Spectrum of Tuberculosis

21 Pathogenesis of Tuberculosis

Mechanisms of Necrosis

Killing Mechanisms

22 Some Other Granulomas

Other Mycobacterial Granulomas

Granulomas of Unknown Aetiology

Granulomas Due To Known Molecules

Modes of Cell Death

23 Determinants of the Course of Infection

Appendix: Technical Methods

Fixation of Tissues

Staining of Organisms in Sections

Identification of Antigen in Tissues

Index