Pathogenesis of Leprosy and Related Diseases

Pathogenesis of Leprosy and Related Diseases

1st Edition - August 1, 1988

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  • Author: D. S. Ridley
  • eBook ISBN: 9781483193601

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Pathogenesis of Leprosy and Related Diseases provides insights into the pathology of granulomatous conditions. The book discusses topics on the factors that induce immunosuppression; immunohistological spectra of granulomatous diseases; study of cutaneous leishmaniasis; and the validity of histopathological analysis. Pathologists, immunologists, experimentalists, and researchers in the medical field will find the book interesting.

Table of Contents

  • Contents




    1 Introduction

    The Study of Pathogenesis

    The Calibration of A Histopathological Picture

    Part I General Considerations

    2 The Structure of Skin

    The Skin Biopsy

    The Normal Skin

    3 The Structure of Peripheral Nerve


    Response To Disease

    4 Inflammation

    Inflammatory Cells

    Acute and Chronic Inflammation

    Granuloma Formation

    Necrosis and Fibrosis

    Immune Complexes and Inflammation

    5 Concepts of the Spectrum

    Part II Leprosy

    6 The Leprosy Bacillus

    Growth Characteristics

    Morphology and Constitution

    7 The Disease Called Leprosy


    The Pathogenesis of the Clinical Picture


    8 The Early Skin Lesion of Leprosy

    The Evolution of the Lesion

    Protected and Optimal Sites

    The Portal of Entry

    9 Neuropathy in Leprosy

    The Pathway of Nerve Involvement

    The Neuropathology of Leprosy

    The Pathogenesis of the Lesion

    Neural Affinity, Immunological Protection and Autoimmunity

    10 Leprosy As A Systemic Disease

    Respiratory Tract

    Vascular Disease

    Reticuloendothelial System

    Other Organs and Tissues

    11 Nature of the Leprosy Spectrum

    Basis of the Ridley-Jopling Classification

    Immunopathology of the Spectrum

    Evolution of the Response

    12 Activity of the Infection

    Phases of Bacterial Multiplication

    The Macrophage Cycle

    Viable and Dead Bacilli

    Reactivity and Relapse

    13 Reactions

    Type 1 (Borderline) Reactions

    Erythema Nodosum Leprosum

    Exacerbation Reactions

    14 The Defect in Leprosy

    Epidemiological Considerations

    Genetic Inheritance

    Portal of Entry

    The Evolution of the Response


    15 Histological Diagnosis

    Principles of Diagnosis

    Early Lesions

    Tuberculoid Lesions

    Differentiation of Reaction and Relapse

    16 Classification

    Histological Classification in Skin

    Histological Classification in Nerve

    Part III Related Diseases

    17 Leishmania and Leishmaniasis

    Speciation and Form of Disease

    The Spectrum of Cutaneous Leishmaniasis

    18 Leishmaniasis: The Tissue Response

    Onset of Infection

    General Pathology of Cutaneous Leishmaniasis

    Alternative Modes of Evolution

    Mucocutaneous Leishmaniasis

    Visceral Leishmaniasis

    19 Leishmaniasis: Pathogenesis

    Initiation of the Infection

    Mechanisms of Parasite Elimination


    20 Tuberculosis and Its Pathology

    The Tubercle Bacillus

    General Pathology

    The Spectrum of Tuberculosis

    21 Pathogenesis of Tuberculosis

    Mechanisms of Necrosis

    Killing Mechanisms

    22 Some Other Granulomas

    Other Mycobacterial Granulomas

    Granulomas of Unknown Aetiology

    Granulomas Due To Known Molecules

    Modes of Cell Death

    23 Determinants of the Course of Infection

    Appendix: Technical Methods

    Fixation of Tissues

    Staining of Organisms in Sections

    Identification of Antigen in Tissues


Product details

  • No. of pages: 262
  • Language: English
  • Copyright: © Butterworth-Heinemann 1988
  • Published: August 1, 1988
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483193601

About the Author

D. S. Ridley

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