Pathogenesis of Leprosy and Related Diseases
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Pathogenesis of Leprosy and Related Diseases provides insights into the pathology of granulomatous conditions. The book discusses topics on the factors that induce immunosuppression; immunohistological spectra of granulomatous diseases; study of cutaneous leishmaniasis; and the validity of histopathological analysis. Pathologists, immunologists, experimentalists, and researchers in the medical field will find the book interesting.
Table of Contents
Contents
Foreword
Preface
Abbreviations
1 Introduction
The Study of Pathogenesis
The Calibration of A Histopathological Picture
Part I General Considerations
2 The Structure of Skin
The Skin Biopsy
The Normal Skin
3 The Structure of Peripheral Nerve
Microanatomy
Response To Disease
4 Inflammation
Inflammatory Cells
Acute and Chronic Inflammation
Granuloma Formation
Necrosis and Fibrosis
Immune Complexes and Inflammation
5 Concepts of the Spectrum
Part II Leprosy
6 The Leprosy Bacillus
Growth Characteristics
Morphology and Constitution
7 The Disease Called Leprosy
Introduction
The Pathogenesis of the Clinical Picture
Immunology
8 The Early Skin Lesion of Leprosy
The Evolution of the Lesion
Protected and Optimal Sites
The Portal of Entry
9 Neuropathy in Leprosy
The Pathway of Nerve Involvement
The Neuropathology of Leprosy
The Pathogenesis of the Lesion
Neural Affinity, Immunological Protection and Autoimmunity
10 Leprosy As A Systemic Disease
Respiratory Tract
Vascular Disease
Reticuloendothelial System
Other Organs and Tissues
11 Nature of the Leprosy Spectrum
Basis of the Ridley-Jopling Classification
Immunopathology of the Spectrum
Evolution of the Response
12 Activity of the Infection
Phases of Bacterial Multiplication
The Macrophage Cycle
Viable and Dead Bacilli
Reactivity and Relapse
13 Reactions
Type 1 (Borderline) Reactions
Erythema Nodosum Leprosum
Exacerbation Reactions
14 The Defect in Leprosy
Epidemiological Considerations
Genetic Inheritance
Portal of Entry
The Evolution of the Response
Immunosuppression
15 Histological Diagnosis
Principles of Diagnosis
Early Lesions
Tuberculoid Lesions
Differentiation of Reaction and Relapse
16 Classification
Histological Classification in Skin
Histological Classification in Nerve
Part III Related Diseases
17 Leishmania and Leishmaniasis
Speciation and Form of Disease
The Spectrum of Cutaneous Leishmaniasis
18 Leishmaniasis: The Tissue Response
Onset of Infection
General Pathology of Cutaneous Leishmaniasis
Alternative Modes of Evolution
Mucocutaneous Leishmaniasis
Visceral Leishmaniasis
19 Leishmaniasis: Pathogenesis
Initiation of the Infection
Mechanisms of Parasite Elimination
Immunosuppression
20 Tuberculosis and Its Pathology
The Tubercle Bacillus
General Pathology
The Spectrum of Tuberculosis
21 Pathogenesis of Tuberculosis
Mechanisms of Necrosis
Killing Mechanisms
22 Some Other Granulomas
Other Mycobacterial Granulomas
Granulomas of Unknown Aetiology
Granulomas Due To Known Molecules
Modes of Cell Death
23 Determinants of the Course of Infection
Appendix: Technical Methods
Fixation of Tissues
Staining of Organisms in Sections
Identification of Antigen in Tissues
Index
Product details
- No. of pages: 262
- Language: English
- Copyright: © Butterworth-Heinemann 1988
- Published: August 1, 1988
- Imprint: Butterworth-Heinemann
- eBook ISBN: 9781483193601
About the Author
D. S. Ridley
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