Paradigms for Study of Neurotrophin Effects in Oxidant Injury, G.R. Jackson and J.R. Perez-Polo. Nitric Oxide Toxicity in Central Nervous System Cultures, V.L. Dawson and T.M. Dawson. Development of in Vitro Injury Models for Oligodendroglia, A. Espinosa, P. Zhao, and J. de Vellis. Glia Models to Study Glial Cell Cytotoxicity, A. Vernadakis and M.S. Kentroti. Rodent Glioma Models, W.W. Maggio. Peripheral Lesioning of Olfacory System: Expression of Neurotrophin Receptors, C.P. Turner and J.R. Perez-Polo. Basal Forebrain Cholinergic Lesions and Complete Transection of Septal-Hippocampal Pathway, L.R. Williams. Neurochemical Lesions: Tools for Functional Assessment of Serotonin Neuronal Systems, J.M. Lakoski, B.J. Keck, and A. Dugar. Cerebral Glucose/Energy Metabolism: Valid Techniques in Humans and Animals, S. Hoyer. Heavy Metal Effects on Glia, E. Tiffany-Castiglioni, M.E. Legare, L.A. Schneider, E.D. Harris, R. Barhoumi, J. Zmudzki, Y. Qian, and R.C. Burghardt. Source, Metabolism, and Function of Cysteine and Glutathione in the Central Nervous System, D.K. Rassin. Magnetic Resonance Spectroscopy of Neural Tissue, R.J. McClure, K.Panchaligam, W.E. Klunk, and J.W. Pettegrew. Acute Stroke Diagnosis with Magnetic Resonance Imaging, S.C. Jones, N.C. Huang, M.J. Quast, A.D. Perez-Trepechio, G.R. Hillman, and T.A. Kent. Evaluation of Free Radical-Initiated Oxidant Events within the Nervous System, S.C. Bondy. Exogenous Administration of Cytokines into the Central Nervous System: Analysis of Alterations in Cell Morphology and Molecular Expression, M.A. Kahn and J. de Vellis. Animal Models to Produce Cortical Cholinergic Dysfunction, R. S
This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed.
@introbul:Key Features @bul:* Neural injury
- Developmental cell death
- Disease processes and aging
- No. of pages:
- © Academic Press 1996
- 26th April 1996
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve
Texas Tech University Health Sciences Center, Lubbock, USA
University of Texas Medical Branch, Galveston, U.S.A.