Pain in Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America

1st Edition, Volume 47-2 - April 7, 2021
Editor: Maripat Corr
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 4 0 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 4 1 - 1

This issue of Rheumatic Disease Clinics, guest edited by Dr. Maripat Corr, will discuss Pain in Rheumatic Diseases. This issue is one of four selected each year by series… Read more

Pain in Rheumatic Diseases, An Issue of Rheumatic Disease Clinics of North America

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This issue of Rheumatic Disease Clinics, guest edited by Dr. Maripat Corr, will discuss Pain in Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Pain mechanisms in patients with rheumatic diseases, The back-pain assessment and treatment in clinical practice, Basic mechanisms of pain in osteoarthritis – experimental observations, NGF promise for management of pain in OA – clinical and experimental aspects, Pivotal role of pain in the lupus patient – cause or effect of poor outcomes, Cannabinoids-hope or hype for pain, Sex differences in Models of pain, Neuropathic pain in AS, and Relationship between inflammation and pain – RA as a model.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Pain Mechanisms in Patients with Rheumatic Diseases
Key points
Introduction
Risk factors
Mechanistic studies
The continuum of fibromyalgia to fibromyalgianess
Clinics care points
Low Back Pain in Adolescent and Geriatric Populations
Key points
Introduction
Acute and chronic pain
Adolescent spine disorders
Geriatric spine disorders (spinal stenosis)
Clinics care points
Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives
Key points
Introduction
The nervous system in osteoarthritis
The role of nerve growth factor in osteoarthritis pain
Neuroimmune involvement in osteoarthritis pain
Clinics care points
Targeting Nerve Growth Factor for Pain Management in Osteoarthritis—Clinical Efficacy and Safety
Key points
Background
Biologic role of nerve growth factor
Clinical outcomes in anti–nerve growth factor trials
Early-phase trials of anti–nerve growth factor agents for hip or knee osteoarthritis
Pre–Food and Drug Administration hold phase III trials of anti–nerve growth factor agents for hip or knee osteoarthritis
Safety concerns and Food and Drug Administration hold
Post-2015 phase III studies in knee and hip osteoarthritis
Anti–nerve growth factor agents for chronic low back pain
Summary
Clinics care points
Pain in Axial Spondyloarthritis: Insights from Immunology and Brain Imaging
Key points
Introduction
Sources of pain in axial spondyloarthritis
Pain perception
Pain transmission
The neuroimmune interface
Central sensitization
Sexual differences in chronic pain
Brain imaging in chronic pain
Brain imaging in ankylosing spondylitis
Pharmacotherapy of pain in spondyloarthritis
Summary
Clinics care points
The Categorization of Pain in Systemic Lupus Erythematosus
Key points
Musculoskeletal pain
Neuropsychological sources of pain
Serositis
Other conditions
Symptom categorization
Summary
Clinics care points
Why It Hurts: The Mechanisms of Pain in Rheumatoid Arthritis
Key points
Introduction
Nociception and types of pain
Peripheral mechanisms of pain: inflammatory cytokines and more
Central mechanisms of pain
Assessing pain in rheumatoid arthritis
Future areas of research
Clinics care points
Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis
Key points
A brief overview of rheumatoid arthritis
Pain in rheumatoid arthritis
Preclinical models and sexual dimorphism in the pain phenotype of rheumatoid arthritis
Summary and future directions
Clinics care points
Cannabinoids and Pain: The Highs and Lows
Key points
Introduction/background
Relevance
Cannabinoids and their receptors
Pharmacology of cannabinoids
Pharmacologic or medical treatment options
Complications
The evidence for cannabinoids and pain
New developments
Summary and future directions
Clinics care points
Nonpharmacologic Pain Management in Inflammatory Arthritis
Key points
Background
Self-efficacy: the foundational principle
Cognitive behavioral therapy
Mindfulness-based interventions
Patient education
Biofeedback
Exercise and physical activity
Massage
Orthotics/splints
Balneotherapy
Acupuncture
Sleep
Depression
Ineffective therapies
Summary
Clinics care points