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Oxygen Sensing - 1st Edition - ISBN: 9780121827854, 9780080497198

Oxygen Sensing, Volume 381

1st Edition

Serial Volume Editors: Gregg Semenza Chandan Sen
eBook ISBN: 9780080497198
Hardcover ISBN: 9780121827854
Imprint: Academic Press
Published Date: 26th March 2004
Page Count: 824
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Table of Contents


1. Assessment of oxygen sensing by model airway and arterial chemoreceptors
P. J. Kemp, C.Peers

2. Methods to study neuroepithelial bodies as airway oxygen sensors.
E. Cutz, X.W. Fu, H. Yeger

3. Role of glutathione redox state in oxygen sensing by carotid body chemoreceptor cells.
C. Gonzalez, G. Sanz-Alfayate, A. Obeso, M. T. Agapito

4. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph
J. P.T. Ward, V. A. Snetkov

5. Oxygen-dependent regulation of pulmonary circulation
R.M. Tuder, S. McGrath, N. F. Voelkel, M. W. Geraci

6. Detection of oxygen sensing during intermittent hypoxia
N. R. Prabhakar,Y.J. Peng, J. L. Overholt, G K. Kumar

7. Functional analysis of the role of HIF-1 in the pathogenesis of hypoxic pulmonary hypertension
G. L. Semenza, L. A. Shimoda


8. Perceived hyperoxia: oxygen regulated signal transduction pathways in the heart
S. Roy, S. Khanna, C. K. Sen

9. Evaluation of Cytochrome P450-4A omega-Hydroxylase and 20-HETE as an O2 Sensing Mechnism in the Microcirculation

10. Assessment of roles for oxidant mechanisms in vascular oxygen sensing
M. S. Wolin, P. M. Kaminski, M. Ahmad, S. A. Gupte
Department of Physiology, New York Medical College, Valhalla, USA.

11. Survival surgery for coronary occlusion and reoxygenation in a rodent model
W. A. Wallace, A. J. Cardounel, S. Khanna, C. K. Sen

12. Measurement of in vivo oxidative stress regulated by the Rac1 GTPase
K. Irani, M. Ozaki

13. Proteomic analysis of the mammalian cell nucleus
A. K. Tewari, S. Roy, S. Khanna, Chandan K. Sen

14. Oxygen-dependent regulation of erythropoiesis
J. T. Prchal, J. Jelinek

15. Physiological responses to chronic anemia in fetal sheep
L. Davis, R. Hohimer

16. Hypoxia-Inducible Factor 1 alpha-Deficient Chimeric Mice as a Model to Study Abnormal B Lymphocyte Development and Autoimmunity


17. Molecular strategies for studying oxygen-sensitive K+ channels
E. Honore, K. Buckler

18. Oxygen sensing by human recombinant K(+) channel: assessment of the use of stable cell lines
P. J. Kemp, D. Iles, C. Peers

19. Methods to study oxygen-sensing sodium channels
A. K. M. Hammarstrom, P. W. Gage
20. Analysis of oxygen-sensitive human cardiac L-type Ca(2+) channel alpha(1C) subunit (hHT isoform)
C. Peers, J. L. Scragg, I. M. Fearon, S. G. Ball, A. Schwartz, G. Varadi


21. Analysis of von Hippel-Lindau tumour suppressor as mediator of cellular oxygen sensing P. J. Ratcliffe, N. Masson

22. Analysis of the von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing
W. G. Kaelin Jr., H. Yang, M. Ivan, J-H. Min, W. Kim

23. Tumor hypoxia and malignant progression
P. Vaupel, A. Mayer, M. Hockel


24. Oxygen dependent regulation of hepatic glucose metabolism
T. Kietzmann

25. Assessing oxygen sensitivity of the multiple drug resistance (MDR1) gene
S. P. Colgan, K. M. Comerford

26. Oxygen-dependent regulation of adipogenesis
A. J. Giaccia, L. M. Swiersz, Z. Yun


27. Methods to detect hypoxia-induced ischemic tolerance in the brain
F. R. Sharp, M. Bernaudin

28. Proximal middle cerebral artery occlusion surgery for the study of ischemia-reoxygenation injury in the brain
A.J. Cardounel, W. A. Wallace, C. K. Sen

29. Carotid chemodenervation approach to study oxygen sensing in brainstem
O. Pascual, J-C. Roux, C. Soulage, M-P. Morin-Surun, M. Denavit-Saubie, J-M. Pequignot

30. Discovery of oxygen responsive genes in pheochromocytoma cells
D. E. Millhorn, K. A. Seta, T. K. Ferguson


31. Oxygen-dependent asparagines hydroxylation
J. Gorman, D. J. Peet, D. Lando, D. A. Whelan, M. L. Whitelaw

32. Deciphering of the oxygen sensing pathway by microscopy
H. Acker, C. Huckstorf, H. Sauer, T. Streller, M. Wartenberg

33. Identification of CREB-dependent transcriptional responses in hypoxia by microarray analysis
C. T. Taylor, M. O. Leonard, S. O’Reilly, K. M. Comerford


34. Determination of the role of HIF-1 in wound healing
J. E. Albina, J. S. Reichner

35. Measuring oxygen in wounds
H. W. Hopf, T. K. Hunt, H. Scheuenstuh., J. M. West, L. M. Humphrey, M.D. Rollins

36. Regulatory role of lactate in wound repair
M. Z. Hussain, Q. P. Ghani, S. Wagner, H. D. Becker, T. K. Hunt

37. Protocols for Topical and Systemic Oxygen Treatments in Wound Healing
G. M. Gordillo, R. Schlanger, W. A. Wallace, V. Bergdall, R. Bartlett


38. Measurement of oxidative stress in cells exposed to hypoxia or other changes in oxygen concentration
R. O. Poyton, R. Dirmeier, K. O’Brien, M. Engle, A. Dodd, E. Spears

39. Evaluation of oxygen response involving differential gene expression in Chlamydomonas reinhardtii
J. del Campo, J. M. Quinn, S. Merchant

40. Resonance Raman and ligand binding analysis of the oxygen-sensing signal transducer protein HemAT from Bacillus subtilis
S. Aono, H. Nakajima, T. Ohta, T. Kitagawa

41. Analysis of FNR as oxygen sensor in Escherichia coli
R. A. Schmitz, S. Achebach, G. Unden
42. Experimental strategies for analyzing oxygen sensing in yeast
R.O. Poyton, R. Dirmeier, K. O’Brien, P. David, A. Dodd


43. Measuring tissue pO2 with microelectrodes
D. G. Buerk

44. Identifying oxygen sensors by their photochemical action spectra
D. F. Wilson

45. Fabrication and in vivo evaluation of NO-releasing electrochemical oxygen sensing catheters
M. E. Meyerhoff, M. C. Frost

46. Methods in optical oxygen sensing: protocols and critical analyses
D. B. Papkovsky

47. Concurrent 31P NMR spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts
P. Pantano, P. Zhao, Y. Zhao, A. D. Sherry

48. MICROXYMETRY: An EPR Spectroscopy Based Method for Simultaneous Measurements of Oxygen Utilization and Free Radicals Production in Enzymatic Reactions
G. Ilangovan, J. L. Zweier, P. Kuppusamy


The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.


Biochemists, cell biologists, molecular biologists, and geneticists


No. of pages:
© Academic Press 2004
26th March 2004
Academic Press
eBook ISBN:
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Ratings and Reviews

About the Serial Volume Editors

Gregg Semenza

Affiliations and Expertise

John Hopkins University School of Medicine, Baltimore, Maryland

Chandan Sen

Chandan Sen

Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling( with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.

Affiliations and Expertise

Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA