The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.


Biochemists, cell biologists, molecular biologists, and geneticists

Table of Contents

LUNG AND THE AIRWAYS 1. Assessment of oxygen sensing by model airway and arterial chemoreceptors P. J. Kemp, C.Peers 2. Methods to study neuroepithelial bodies as airway oxygen sensors. E. Cutz, X.W. Fu, H. Yeger 3. Role of glutathione redox state in oxygen sensing by carotid body chemoreceptor cells. C. Gonzalez, G. Sanz-Alfayate, A. Obeso, M. T. Agapito 4. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph J. P.T. Ward, V. A. Snetkov 5. Oxygen-dependent regulation of pulmonary circulation R.M. Tuder, S. McGrath, N. F. Voelkel, M. W. Geraci 6. Detection of oxygen sensing during intermittent hypoxia N. R. Prabhakar,Y.J. Peng, J. L. Overholt, G K. Kumar 7. Functional analysis of the role of HIF-1 in the pathogenesis of hypoxic pulmonary hypertension G. L. Semenza, L. A. Shimoda CARDIOVASCULAR AND BLOOD 8. Perceived hyperoxia: oxygen regulated signal transduction pathways in the heart S. Roy, S. Khanna, C. K. Sen 9. Evaluation of Cytochrome P450-4A omega-Hydroxylase and 20-HETE as an O2 Sensing Mechnism in the Microcirculation 10. Assessment of roles for oxidant mechanisms in vascular oxygen sensing M. S. Wolin, P. M. Kaminski, M. Ahmad, S. A. Gupte Department of Physiology, New York Medical College, Valhalla, USA. 11. Survival surgery for coronary occlusion and reoxygenation in a rodent model W. A. Wallace, A. J. Cardounel, S. Khanna, C. K. Sen 12. Measurement of in vivo oxidative stress regulated by the Rac1


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© 2004
Academic Press
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