Origins of Resistance to Toxic Agents

Origins of Resistance to Toxic Agents

1st Edition - January 1, 1955

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  • Editor: M Sevag
  • eBook ISBN: 9780323148320

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Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on March 25-27, 1954. Contributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other processes. This text is organized into five sections encompassing 25 chapters and begins with an overview of the evolutionary aspects of resistance to antibacterial agents, herbicides, and insecticides. The book then discusses spontaneous and induced mutations to drug resistance in Escherichia coli, along with the mechanism of drug resistance in protozoa and bacteria, the physiological aspects of insect resistance to insecticides, and the enzymatic detoxication of DDT. The next chapters focus on the origins of tolerance and addiction to drugs and the problem of alcoholism; biochemical effects of narcotics and alcohol administration; tolerance and physical dependence to narcotics; and resistance and dependence in cancer cells. The book concludes by analyzing the significance of protein configuration to the specificity of biological interaction. This book is a valuable source of information for physicians, biochemists, pharmacologists, entomologists, plant physiologists, students of cancer, and those who are interested in the theory of the evolution of living matter.

Table of Contents

  • Preface

    List of Contributors

    Session I. Resistance to Microbicides Introductory Remarks

    Spontaneous and Induced Mutations to Drug Resistance in Escherichia coli

    Origin of Drug Resistance in Microorganisms

    Mechanism of Resistance to Proflavine in Bacterium lactis aerogenes (Aerobacter aerogenes)

    Mechanism of the Origin of Resistance to Drugs in Protozoa


    Session II. Resistance to Herbicides and Insecticides Introductory Remarks

    Resistance of Plants to Herbicides

    Resistance Factors Against Leptinotarsa decemlineata Say, Isolated from the Leaves of Wild Solanum Species

    Physiological Aspects of Insect Resistance to Insecticides

    The Enzymatic Detoxication of DDT


    Theories on Evolution

    Session III. Tolerance and Addiction to Drugs and Alcoholism Introductory Remarks

    Some Effects of Alcohol on Metabolic Mechanisms with Applications to Therapy of Alcoholics

    The Genetotrophic Approach to Alcoholism

    Biochemical Effects of Administration of Narcotics and Alcohol

    The Phenomena of Tolerance

    Possible Mechanisms of Physical Dependence to Narcotics


    Session IV. Resistance Factors, Infectious Agents, and Cancer Cells Introductory Remarks

    Studies on Transformations to Resistance and Dependence in Leukemic Cells

    Biochemical Investigations on the Mechanism of Carcinogenesis by the Aminoazo Dyes

    The Nature of Tumor Immunity

    Factors in Resistance to Infectious Agents


    Session V. Physiological, Chemical, and Genetic Viewpoints Introductory Remarks

    Biochemical Genetics in Relation to the Action of Drugs and Inhibitors

    Protein Molecule, Resistance to Microbicides, Mutations, and Related Problems

    Experiments in Microevolution. A Summary from the Physiological Viewpoint


    Appendix I. Posing of the Basic Questions

    Appendix II. Historical Notes

    Author Index

    Subject Index

Product details

  • No. of pages: 488
  • Language: English
  • Copyright: © Academic Press 1955
  • Published: January 1, 1955
  • Imprint: Academic Press
  • eBook ISBN: 9780323148320

About the Editor

M Sevag

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