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Origins of Resistance to Toxic Agents - 1st Edition - ISBN: 9780123956590, 9780323148320

Origins of Resistance to Toxic Agents

1st Edition

Editor: M Sevag
eBook ISBN: 9780323148320
Imprint: Academic Press
Published Date: 1st January 1955
Page Count: 488
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Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on March 25-27, 1954. Contributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other processes. This text is organized into five sections encompassing 25 chapters and begins with an overview of the evolutionary aspects of resistance to antibacterial agents, herbicides, and insecticides. The book then discusses spontaneous and induced mutations to drug resistance in Escherichia coli, along with the mechanism of drug resistance in protozoa and bacteria, the physiological aspects of insect resistance to insecticides, and the enzymatic detoxication of DDT. The next chapters focus on the origins of tolerance and addiction to drugs and the problem of alcoholism; biochemical effects of narcotics and alcohol administration; tolerance and physical dependence to narcotics; and resistance and dependence in cancer cells. The book concludes by analyzing the significance of protein configuration to the specificity of biological interaction. This book is a valuable source of information for physicians, biochemists, pharmacologists, entomologists, plant physiologists, students of cancer, and those who are interested in the theory of the evolution of living matter.

Table of Contents


List of Contributors

Session I. Resistance to Microbicides Introductory Remarks

Spontaneous and Induced Mutations to Drug Resistance in Escherichia coli

Origin of Drug Resistance in Microorganisms

Mechanism of Resistance to Proflavine in Bacterium lactis aerogenes (Aerobacter aerogenes)

Mechanism of the Origin of Resistance to Drugs in Protozoa


Session II. Resistance to Herbicides and Insecticides Introductory Remarks

Resistance of Plants to Herbicides

Resistance Factors Against Leptinotarsa decemlineata Say, Isolated from the Leaves of Wild Solanum Species

Physiological Aspects of Insect Resistance to Insecticides

The Enzymatic Detoxication of DDT


Theories on Evolution

Session III. Tolerance and Addiction to Drugs and Alcoholism Introductory Remarks

Some Effects of Alcohol on Metabolic Mechanisms with Applications to Therapy of Alcoholics

The Genetotrophic Approach to Alcoholism

Biochemical Effects of Administration of Narcotics and Alcohol

The Phenomena of Tolerance

Possible Mechanisms of Physical Dependence to Narcotics


Session IV. Resistance Factors, Infectious Agents, and Cancer Cells Introductory Remarks

Studies on Transformations to Resistance and Dependence in Leukemic Cells

Biochemical Investigations on the Mechanism of Carcinogenesis by the Aminoazo Dyes

The Nature of Tumor Immunity

Factors in Resistance to Infectious Agents


Session V. Physiological, Chemical, and Genetic Viewpoints Introductory Remarks

Biochemical Genetics in Relation to the Action of Drugs and Inhibitors

Protein Molecule, Resistance to Microbicides, Mutations, and Related Problems

Experiments in Microevolution. A Summary from the Physiological Viewpoint


Appendix I. Posing of the Basic Questions

Appendix II. Historical Notes

Author Index

Subject Index


No. of pages:
© Academic Press 1955
1st January 1955
Academic Press
eBook ISBN:

About the Editor

M Sevag

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