Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians.


Key Features

  • Summarizes the key morphological and cellular events
  • Emphasizes up-to-date research relating to molecular control mechanisms
  • Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease
  • Distils common themes and differences for comparative studies
  • Highlights key remaining questions and sets the agenda for future research


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  1. How to Make a Heart: The Origin and Regulation of Cardiac
  2. Progenitor Cells

    Ste´phane D. Vincent and Margaret E. Buckingham

  3. Vascular Development—Genetic Mechanisms and Links to
  4. Vascular Disease

    John C. Chappell and Victoria L. Bautch

  5. Lung Organogenesis
  6. David Warburton, Ahmed El-Hashash, Gianni Carraro, Caterina Tiozzo,

    Frederic Sala, Orquidea Rogers, Stijn De Langhe, Paul J. Kemp,

    Daniela Riccardi, John Torday, Saverio Bellusci, Wei Shi,

    Sharon R Lubkin, and Edwin Jesudason

  7. Transcriptional Networks and Signaling Pathways that Govern
  8. Vertebrate Intestinal Development

    Joan K. Heath

  9. Kidney Development: Two Tales of Tubulogenesis
  10. Melissa Little, Kylie Georgas, David Pennisi, and Lorine Wilkinson

  11. The Game Plan: Cellular and Molecular Mechanisms of
  12. Mammalian Testis Development

    Elanor N. Wainwright and Dagmar Wilhelm

  13. Building Pathways for Ovary Organogenesis in the
  14. Mouse Embryo

    Chia-Feng Liu, Chang Liu, and Humphrey H-C Yao

  15. Vertebrate Skeletogenesis
  16. Ve´ronique Lefebvre and Pallavi Bhattaram

  17. The Molecular Regulation of Vertebrate Limb Patterning
  18. Natalie C. Butterfield, Edwina McGlinn, and Carol Wicking

  19. Eye Development

Jochen Graw


No. of pages:
© 2010
Academic Press
eBook ISBN:
Print ISBN:

About the author