Description

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

Key Features

  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

Series Page

List of Contributors

Preface

Chapter 1. Many faces of orexin/hypocretin

Chapter 2. Overview of orexin/hypocretin system

Introduction

Discovery of orexin/hypocretin

Loss of orexin signaling causes narcolepsy

Orexin neurons as stabilizer of sleep/wakefulness states

Integrative physiology of orexin system

Clinical perspectives

Chapter 3. Hypocretins and the neurobiology of sleep–wake mechanisms

Introduction

Discovery and properties of the hypocretins

Loss of function

Hypocretin neuronal activity

Arousal circuits modulated by the hypocretins

The hypocretins as an integrator circuit in arousal

Chapter 4. Respiration and autonomic regulation and orexin

Introduction

Orexins and breathing

Orexins and blood pressure

Orexins and thermoregulation

Development of the orexin system

Concluding remarks

Chapter 5. Orexins, feeding, and energy balance

Introduction

Functional neuroanatomy of the orexin system

Activity of orexin neurons

Orexin neurons and regulation of food intake

Orexin and regulation of energy homeostasis

Effects of orexin on autonomic nervous system

Concluding remarks

Chapter 6. Orexin and natural reward

Introduction

Orexin, feeding, and energy homeostasis

Orexin and food motivation and reward

Orexin and other naturally rewarding behaviors

Orexin and maternal behavior

Orexin and sexual performance and motivation

Orexin and sexual reward

Conclusions

Chapter 7. Multiple roles for orexin/hypocretin in addiction

Introduction and overview

Animal models of addiction

Orexin roles in drug seeking

Brain circuits underlying orexin modulation of drug seeking

Behavioral pharmacology of orexin

Details

No. of pages:
208
Language:
English
Copyright:
© 2012
Published:
Imprint:
Elsevier
Print ISBN:
9780444594891
Electronic ISBN:
9780444594907