Oral Delivery of Insulin

1st Edition

Authors: T.A. Sonia Chandra P. Sharma
Hardcover ISBN: 9781907568473
eBook ISBN: 9781908818683
Imprint: Woodhead Publishing
Published Date: 4th December 2014
Page Count: 290
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Table of Contents

    <li>List of figures and tables<ul><li>Figures</li><li>Tables</li></ul></li> <li>About the authors</li> <li>1: Diabetes mellitus &#x2013; an overview<ul><li>Abstract</li><li>1.1 Diabetes mellitus &#x2013; an introduction</li><li>1.2 Glucose homeostasis</li><li>1.3 Types of diabetes</li><li>1.4 Symptoms of diabetes</li><li>1.5 Complications of diabetes</li><li>1.6 Diagnosis of diabetes mellitus</li><li>1.7 Therapy for diabetes</li><li>1.8 Non-insulin treatment options of type 1 diabetes</li><li>1.9 Treatment options of type 2 diabetes</li><li>1.10 Conclusion</li></ul></li> <li>2: Routes of administration of insulin<ul><li>Abstract</li><li>2.1 Current approach for the delivery of insulin</li><li>2.2 Routes of administration of insulin</li><li>2.3 Conclusion</li></ul></li> <li>3: Oral insulin delivery &#x2013; challenges and strategies<ul><li>Abstract</li><li>3.1 Oral delivery of insulin</li><li>3.2 Barriers to oral delivery of insulin</li><li>3.3 Strategies and alternatives to improve oral insulin delivery</li><li>3.4 Conclusion</li></ul></li> <li>4: Experimental techniques involved in the development of oral insulin carriers<ul><li>Abstract</li><li>4.1 Introduction</li><li>4.2 Polymeric nanoparticles</li><li>4.3 Physicochemical characterization of nanoparticles</li><li>4.4 Biological evaluation</li><li>4.5 <i>In vitro</i> method for assessing drug permeability</li><li>4.6 <i>In vivo</i> study of oral insulin</li><li>4.7 Biodistribution studies</li><li>4.8 Conclusion</li></ul></li> <li>5: Lipids and inorganic nanoparticles in oral insulin delivery<ul><li>Abstract</li><li>5.1 Lipid-based systems for oral delivery of insulin</li><li>5.2 Liposomes</li><li>5.3 Solid lipid nanoparticles</li><li>5.4 Nanostructured lipid carriers</li><li>5.5 Niosomes</li><li>5.6 Archaeosomes</li><li>5.7 Cubic nanoparticles (cubosomes)</li><li>5.8 Aquasomes</li><li>5.9 Inorganic nanoparticles as carriers for oral insulin delivery</li><li>5.10 Co


Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

Key Features

  • Presents an overview of Diabetes Mellitus
  • Includes a discussion of various strategies and techniques adopted for oral delivery of insulin
  • Presents an update of research in the field


Scientists, researchers and students in the field of Medical sciences.


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"...a comprehensive account of the status of oral insulin delivery...any scientist beginning work in the field should read their book…" --International Journal of Pharmaceutics

About the Authors

T.A. Sonia Author

T. A. Sonia is a doctoral student working in the field of development of polymeric nano/micro particles for oral delivery of insulin under the guidance of Dr Chandra P Sharma at Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India. She completed her graduate studies in Polymer Science from School of Chemical Sciences, Mahatma Gandhi University, Kerala, India.

Affiliations and Expertise

Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India.

Chandra P. Sharma Author

Chandra P. Sharma is the Acting Head of Biomedical Technology Wing and Associate Dean - PhD Programme, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India, and has been the Head of the Biosurface Technology Division since 1980. His areas of expertise include: biomaterials science and engineering; polymeric and metallic micro/nano particles based delivery systems; and surface modification and tissue/blood compatibility of materials. Dr. Sharma has published over 325 research papers with over 2600 citations (Scopus) and has processed 32 patents including in Canada, European Union, Japan and USA. He has served as guest editor and reviewer of several international journals and has edited books with Dr. Michael Szycher on Blood Compatible Materials and Devices, and on Biointegration of medical implant materials: Science and design, with Woodhead Publishing. His laboratory has completed leading research in the field.

Affiliations and Expertise

Sree Chitra Tirunal Institute for Medical Sciences and Technology, India