One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B

1st Edition, Volume 368 - May 20, 2022
Editors: Samanta Antonella Mariani, Luca Cassetta
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 4 3 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 7 4 4 - 6

One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role o… Read more

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One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role of macrophages in health and diseases, with a special focus on the role of macrophages during development. New chapters cover The role of salivary gland macrophages in infection, disease and repair, Reprogramming or replacing brain macrophages to treat neurodegenerative disease, Targeting macrophages for cancer immunotherapy, Heart Macrophages at steady-state and disease: simple bystanders or active players?, Macrophages in the liver, and Developmental programming of macrophages.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter One: The role of salivary gland macrophages in infection, disease and repair
Abstract
1: Introduction
2: Salivary gland structure
3: Salivary gland macrophage characterization
4: Salivary gland macrophage maintenance
5: Salivary gland macrophages in infection
6: Salivary gland macrophages in disease
7: The role of salivary gland macrophages in development
8: The role of salivary gland macrophages in repair and regeneration
9: Macrophages in salivary gland cancer and immunotherapy
10: The macrophage niche
11: Conclusions and future perspectives
Acknowledgments
References
Chapter Two: Mertk: An emerging target in cancer biology and immuno-oncology
Abstract
1: Introduction
2: Consequences of Mertk activation
3: Immunology of Mertk activation
4: Rationale for targeting Mertk as a therapeutic
5: Therapeutic strategies and current progress
6: Concluding remarks and future perspectives
References
Chapter Three: Targeting tumor-associated macrophages for cancer immunotherapy
Abstract
1: Macrophages
2: Subclasses of macrophages
3: Macrophages in diseases
4: Macrophages in cancer: Tumor-associated macrophages
5: Clinical significance of TAMs
6: Therapeutic strategies to target TAMs
7: Rational combination of TAM-targeting therapeutics with conventional therapies
8: Discussion
References
Chapter Four: Macrophages in the heart: Active players or simple bystanders?
Abstract
1: Introduction
2: Healthy heart
3: Cardiac resident macrophages' functions at steady-state
4: Dysfunctional heart
5: Open questions and concluding remarks
References
Chapter Five: Macrophages as key regulators of liver health and disease
Abstract
1: Introduction
2: Macrophage heterogeneity in the healthy liver
3: Macrophages in acute liver injury
4: Macrophages in chronic liver injury
5: Macrophages in hepatocellular carcinoma
6: Therapeutic targeting of liver macrophages
7: Summary and future perspectives
References
Chapter Six: Developmental programming of macrophages by early life adversity
Abstract
1: Macrophages
2: Developmental programming
3: Macrophage programming
4: Concluding remarks and open questions
References

Samanta Antonella Mariani

After defending an experimental thesis on malignant haematopoiesis, Samanta Mariani obtained a Master’s Degree in Medical Biotechnology from the University of Modena and Reggio Emilia (Italy). She then moved to Milan to join an international PhD programme on Cellular and Molecular Biology held by the Vita-Salute San Raffaele University and the Open University of London. During the four years of her PhD in Professor Guido Poli’s laboratory, she worked on HIV-1 biology. After successfully defending her PhD thesis, she decided to move to the United States to experience a new research environment and broaden her scientific expertise. Changing scientific topics between the Master’s and PhD led to her fascination in human haematopoiesis and the desire to find a postdoc in that field. Thus, she joined the laboratory of Professor Bruno Calabretta at the Thomas Jefferson University of Philadelphia. At the end of 2014, she joined Professor Elaine Dzierzak's laboratory for a second postdoc at the University of Edinburgh. Here she worked on different projects focused on steady-state developmental haematopoiesis and immunology. In 2021, she was awarded a Chancellor's Fellowship, a John Goldman Fellowship and entry to the ESAT tenure-track programme at the University of Edinburgh. This allowed her to open up a new line of research on embryonic macrophages and their role in health and disease, with a special focus on normal and malignant foetal/infant haematopoiesis.

Affiliations and expertise

The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ

Luca Cassetta

Dr Cassetta is a co-Founder of Macomics and is an immunologist with in-depth knowledge of human myeloid cell biology applied to different human diseases. He obtained a PhD in immunology at the S.Raffaele Institute in Milan studying the role of macrophage polarization in HIV pathogenesis; he then moved to NY at the Albert Einstein Medical College in the lab of Prof. Jeffrey Pollard where he studied Tumor Associated Macrophages in breast cancer. He then moved to the University of Edinburgh continuing his studies on TAMs where he established his own lab as principal investigator. His extensive experience in human macrophage biology contributed to the development of the Macomics screening platform. Dr Cassetta is an author of multiple publications in high-impact international scientific journals including Cancer Cell, Nature Communications, Journal of Experimental Medicine, Blood, PNAS, Nature Reviews Drug Discovery. He was awarded the Innovation Prize cup 2019 as a young entrepreneur for the spinout company, Macomics. Dr Cassetta joined Macomics full time as VP Immunology in 2021.

Affiliations and expertise

The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ