Obesity, Volume 91

1st Edition

Hardcover ISBN: 9780124077669
eBook ISBN: 9780124115170
Imprint: Academic Press
Published Date: 11th February 2013
Page Count: 512
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Table of Contents

Former Editors



Chapter One. Hormonal Regulation of Lipogenesis

1 Introduction

2 Defining Lipogenesis

3 Lipogenesis in Metabolic Target Tissues

4 Regulation of Lipogenesis

5 Hormonal Regulation

6 Conclusions


Chapter Two. Genetic Determinants of Obesity and Related Vascular Diseases

1 Introduction

2 Genetic Determinants of Obesity

3 Vascular Diseases Related to Overweight and Obesity

4 Conclusions


Chapter Three. Brd2 Gene Disruption Causes “Metabolically Healthy” Obesity: Epigenetic and Chromatin-Based Mechanisms that Uncouple Obesity from Type 2 Diabetes


1 Introduction: The Problem of Obesity and Its Complications

2 Complex Polygenic Interactions with the Environment and Epigenetics in Obesity

3 The “brd2 lo” Mouse Model of “Metabolically Healthy” Obesity

4 Who are “Metabolically Healthy” Obese Humans?

5 Other Animal Models of “Metabolically Healthy” Obesity

6 Derepression of Insulin Transcription in the “brd2 lo” Environment

7 Translational Implications of Epigenetic Reprogramming: Conclusions


Chapter Four. The TBC1D1 Gene: Structure, Function, and Association with Obesity and Related Traits

1 Introduction

2 TBC1D1 Gene Structure and Expression

3 TBC1D1 Protein Structure and Function

4 The TBC1D1 Gene in Obesity and Related Traits

5 Conclusions


Chapter Five. Replication Initiator 1 in Adipose Tissue Function and Human Obesity

1 Introduction

2 Structure of Repin1

3 Cellular Localization of Repin1

4 Repin1 Function in Adipose Tissue

5 Concluding Remarks



First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on obesity.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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© Academic Press 2013
Academic Press
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