Obesity Hypoventilation Syndrome

Obesity Hypoventilation Syndrome: From Physiologic Principles to Clinical Practice summarizes the current state of knowledge regarding the epidemiology, physiology and treatment of obesity hypoventilation syndrome (OHS). Currently, the identification and management of OHS is suboptimal, especially in the acute setting, hence the misdiagnosis or mislabeling of the problem has a significant impact on patient outcomes. This volume brings together all aspects of assessment and management into a main resource for understanding the complex physiological and clinical consequences of this condition.

• Provides one page chapter summaries that cover epidemiology, physiology and treatment options
• Presents an easy to use reference on obesity hypoventilation syndrome, including symptoms
• Contains chapters with detailed discussions of topics, including color images, graphs and tables that summarize current research

Research scientists as well as respiratory and sleep medicine specialists

Part 1 A historical introduction
Section I. Obesity
Section II. A History of Obesity Hypoventilation

Part 2 Definitions, epidemiology, morbidity, mortality, and quality of life
Section I. Obesity: epidemiology and its effect on health
Section II. OSA: epidemiology and effect on health
Section III. Epidemiology of obesity hypoventilation

Part 3 Pathophysiology of obesity hypoventilation syndrome
Section I. The normal physiology of breathing during sleep
Section II. Pathophysiology of sleep disordered breathing
Section III. The pathophysiology of obesity hypoventilation
Section IV. Renal compensation for chronic to respiratory acidosis
Section V. Evolution of obesity hypoventilation
Section VI. Derangements of inflammation, the central nervous system, and cardiovascular system in obesity hypoventilation

Part 4 Clinical assessment of a patient with obesity hypoventilation
Section I. Clinical manifestations of obesity hypoventilation
Section II. Detection of hypoventilation (arterial, venous, cutaneous, end tidal, HCO3, interpretation of acid-base)
Section III. Diagnosis of sleep disordered breathing (PSG, portable)

Part 5 Management of obesity hypoventilation syndrome
Section I. Weight loss
Section II. Review the effect of weight loss on the pathophysiology of sleep apnea and OHS
Section III. Positive airway pressure therapy I: Equipment
Section IV. Positive airway pressure therapy II: Setting and Outcomes
Section V. Medications
Section VI. Tracheostomy and airways surgery
Section VII. Acute on chronic respiratory failure
Section VIII. Obesity hypoventilation and surgery