Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases.

Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes.

Key Features

  • Scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndrome
  • Includes coverage of Pre-diabetes conditions plus both Type I and Type II Diabetes
  • Presents both prevention and treatment options


Nutritionist researchers and practitioners, food microbiologists and toxicologists, and pharmacologists, public health officials, health professionals, endocrinologists, nurses and general practitioners

Table of Contents

Chapter 1: Type1 Diabetes Mellitus: An Overview / Saleh Adi, Andrea Gerard Gonzalez
Chapter 2: An Overview on Type 2 Diabetes / Jonathan Pinkney, Julie Tomlinson, Elizabeth Stenhouse
Chapter 3: Pathogenesis of Type 2 Diabetes- A Comprehensive Analysis / Jeff Unger
Chapter 4: Managing the Broad Spectrum of Type 2 Diabetes / Evelyne Fleury-Milfort
Chapter 5: Prediabetes: Prevalence, Pathophysiology and Recognition of Enhanced Risk / Alok K. Gupta, Ajay Menon, William D. Johnson
Chapter 6: Obesity and Type 2 Diabetes in Youths: New Challenges to Overcome / Santoro Nicola, Cosimo Giannini, Sonia Caprio
Chapter 7: Diabetes Pathophysiology- A Nutritional Perspective / Kevin J. Acheson
Chapter 8: Diabetes pathophysiology- A Nurse’s Perspective / Anne Jessup
Chapter 9: Roles of Environmental Pollution and Pesticides in the Metabolic Syndrome and Diabetes:  The Epidemiological Evidence / Ivar L. Frithsen, Charles J. Everett
Chapter 10: Preventing Diabetes with Diet and Exercise / Karen Z. Walker, Kerin O'Dea

Chapter 11: The Role of Insulin Resistance in the Cardiorenal Syndrome / Jaya P. Buddineni, Adam Whaley-Connell, James Sowers
Chapter 12: An Overview on Diabetic Nephropathy / Kei Fukami, Sho-ichi Yamagishi
Chapter 13: An Overview on Diabetes and Ocular Health / Shintaro Nakao, Yasuaki Hata
Chapter 14: An Overview on Diabetic Retinopathy / Stephen G. Schwartz, Harry W. Flynn, Jr.
Chapter 15: Role of Peripheral Neuropathy in the Development of Foot Ulceration and Impaired Wound Healing in Diabetes Mellitus / Francesco Tecilazich, Thanh L. Dinh, Aristidis Veves
Chapter 16: An Overview on Gestational Diabetes / Christopher Federico, Gabriella Pridjian

Chapter 17: Gene-En


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Academic Press
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About the authors

Debasis Bagchi

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 till Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, till June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. Dr. Bagchi has 315 papers in peer reviewed journals, 27 books and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and other peer reviewed journals.

Affiliations and Expertise

Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, TX, USA

Sreejayan Nair

Dr. Sreejayan Nair is a Professor of Pharmacology and the Associate Dean for Research in the School of Pharmacy, College of Health Sciences, University of Wyoming. He also serves as the Director of the interdisciplinary Biomedical Sciences Graduate Program in the University of Wyoming. Dr. Nair earned his bachelors, masters and PhD degree in Pharmaceutical Sciences from the College of Pharmaceutical Sciences, Manipal, India. He received his post-doctoral trainings at the Department of Medicine-II, Ludwig Maximillians University, Klinikum Grosshadern, Munich, Germany, and at the Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN. His research interests are diabetes and cardiovascular disease. He has published over 75 research papers in peer-reviewed journals and presented at various national and international conferences. His research has been funded by the American Heart Association, American Diabetes Association, and the National Institutes of Health. He has co-edited three books related to diabetes and cardiovascular disease. He is a Fellow of the American College of Nutrition.

Affiliations and Expertise

School of Pharmacy, University of Wyoming, Laramie, WY, USA