Table of Contents




SECTION I. Epidemiology and Overview

Chapter 1. Type 1 Diabetes Mellitus






Clinical Presentation




Prevention and Intervention Trials

Chapter 2. Overview of Type 2 Diabetes

Definition and Diagnostic Criteria

Epidemiology of Type 2 Diabetes and Its Complications

Genetic Risk Factors for Type 2 Diabetes

Risk Factors and Screening for Type 2 Diabetes

Diabetes in Pregnancy: Implications for Mother and Offspring

Evidence for Metabolic Programming of Diabetes in Early Life

Early Intervention in Type 2 Diabetes

Clinical Management of Type 2 Diabetes

Treatment Guidelines

Nutrition and Lifestyle Intervention

Pharmacological Treatments

Bariatric Surgery

Economic Impact of Type 2 Diabetes

Future Directions

Chapter 3. Pathogenesis of Type 2 Diabetes—A Comprehensive Analysis


Genetics of Type 2 Diabetes

Maintenance of Normal Glucose Homeostasis

Impaired Glucose Homeostasis in Patients with Type 2 Diabetes

Mechanistic Actions Which Lead to Progressive β-Cell Failure and Type 2 Diabetes


Chapter 4. Managing the Broad Spectrum of Type 2 Diabetes


Evolving Pathophysiology of Type 2 Diabetes

Altering The Progression of Type 2 Diabetes

Need for Early Intervention

Aggressive Management After Diagnosis

How Low Do We Go for Glycemic Control?

Treatment Options

Self-Management Education

Lifestyle Modification

Meal Planning

Physical Activity

Pharmacological Treatment

When to Adjust Treatment

Initiating Insulin Therapy

Insulin Delivery Devices



No. of pages:
© 2012
Academic Press
eBook ISBN:
Print ISBN:

About the editors

Debasis Bagchi

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 till Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, till June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. Dr. Bagchi has 315 papers in peer reviewed journals, 27 books and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and other peer reviewed journals.

Affiliations and Expertise

Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, TX, USA

Sreejayan Nair

Dr. Sreejayan Nair is a Professor of Pharmacology and the Associate Dean for Research in the School of Pharmacy, College of Health Sciences, University of Wyoming. He also serves as the Director of the interdisciplinary Biomedical Sciences Graduate Program in the University of Wyoming. Dr. Nair earned his bachelors, masters and PhD degree in Pharmaceutical Sciences from the College of Pharmaceutical Sciences, Manipal, India. He received his post-doctoral trainings at the Department of Medicine-II, Ludwig Maximillians University, Klinikum Grosshadern, Munich, Germany, and at the Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN. His research interests are diabetes and cardiovascular disease. He has published over 75 research papers in peer-reviewed journals and presented at various national and international conferences. His research has been funded by the American Heart Association, American Diabetes Association, and the National Institutes of Health. He has co-edited three books related to diabetes and cardiovascular disease. He is a Fellow of the American College of Nutrition.

Affiliations and Expertise

School of Pharmacy, University of Wyoming, Laramie, WY, USA