Nutrition and Drug Interrelations

Nutrition and Drug Interrelations

1st Edition - January 28, 1978

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  • Editor: John Hathcock
  • eBook ISBN: 9780323141970

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Nutrition and Drug Interrelations examines and presents the different relations of nutrition, metabolism, and effects of drugs, including drugs' positive effects in the field of animal husbandry and human and veterinary medicine. This book also highlights the importance of the interrelations between nutrition and drugs. The introductory chapter gives an overview of the variable role of food in humans on a historical and sociological context and perspective. The first section of this book deals with the impacts of drugs on the nutrition process. These impacts can either be harmless or harmful depending on the adequacy of nutrition. The second section of this book describes some of the many influences of nutritional condition on biochemical competence to cope with xenobiotics, including drugs. The third section highlights the various uses of pharmacological agents in food production. This section also discusses some concerns about the effect in the food chain of pharmacological agents. The last section in this book demonstrates the overlap in boundary between dietetic and pharmacological treatments. Given focus is the use of vitamin D derivatives and megavitamin treatments with doubtful benefits. This book will benefit most students and professionals in the field of food and nutrition, human and veterinary medicine, and animal husbandry. The subject area in this book will also yield interest from people involved in metabolism, nutrition, and pharmacology.

Table of Contents

  • List of Contributors



    1 The Agile Role of Food: Some Historical Reflections

    I. Food as Patriotism

    II. The Vast Variety of Food Image and Role

    III. The American Version of Food Folklore

    IV. The New Nutrition and Its Manipulation

    V. The Vitamin Amendments of 1976


    Section I / Drug Effects on Nutrient intake, Function, and Requirement

    2 Appetite Regulation and Its Modulation by Drugs

    I. Introduction

    II. Regulation of Feeding Behavior

    III. Disorders of Appetite Regulation

    IV. Drugs Affecting Food Intake

    V. Summary and Research Needs


    3 Drugs and Water-Soluble Vitamin Absorption

    I. Introduction: Principles of Intestinal Absorption

    II. Water-Soluble Vitamin Absorption and Drug Inhibition

    III. Discussion: Research Needs


    4 Drug Effects on Fat-Soluble Vitamin Absorption

    I. Introduction

    II. Physiology of Digestion, Absorption, and Transport of Fat-Soluble Vitamins

    III. Drugs Affecting Fat-Soluble Vitamin Absorption

    IV. Miscellaneous Effects of Drugs on Fat-Soluble Vitamin Absorption

    V. Research Needs

    VI. Conclusion


    5 Drugs and Environmental Chemicals in Relation to Vitamin Needs

    I. Introduction

    II. Human Findings in Marginal Deficiency States

    III. Some Drug-Vitamin Interrelations

    IV. Implications of Marginal Deficiency on Human Performance

    V. Preventive/Corrective Proposals to Attain Nutritional Adequacy

    VI. Summary


    6 Effects of Oral Contraceptives on Nutrient Utilization

    I. Introduction

    II. Effects of Oral Contraceptives on Amino Acid and Protein Metabolism

    III. Vitamin Requirements and Utilization

    IV. Metals

    V. Conclusions and Future Research


    7 Nutritional Impact of Intestinal Drug-Microbe Interactions

    I. Introduction and Definitions

    II. The Role of the Intestinal Microflora in Host Nutrition

    III. Transformations of Foreign Compounds by Intestinal Microorganisms

    IV. The Nutritional Consequences of Drug-Microbe Interactions in the Intestines of Monogastric Animals

    V. The Influence of Anutrients, Foreign Compounds, and Drugs on the Fermentation in the Forestomachs of Polygastric Animals

    VI. Research Needs


    8 Interactions of Drugs and Intestinal Mucosal Endoplasmic Reticulum

    I. Introduction

    II. Distribution of Drug-Metabolizing Enzymes in the Intestine

    III. Biochemical Properties of Some Intestinal Microsomal Drug-Metabolizing Enzymes

    IV. Factors Affecting Intestinal Drug Metabolism

    V. Conclusions and Research Needs


    9 Drug Effects on Gastric Mucosa

    I. Pathogenesis

    II. Drug Treatment of Gastric Mucosal Damage

    III. Research Needs


    Section II / Nutritional Effects on Drug Metabolism and Action

    10 Nutrients in Drug Detoxication Reactions

    I. Introduction

    II. The Metabolic Reactions of Drugs

    III. Nutrients Required in Phase I Reactions

    IV. Nutrients in Phase II Reactions or Conjugations

    V. General Mechanism of Conjugation and Nutrients Required

    VI. Conclusion


    11 Diet-Drug Interactions and Incompatibilities

    I. Introduction

    II. Influence of Food and Other Dietary Constituents on Drug Absorption

    III. Vitamin Intakes and Drug Responses

    IV. Drug-Induced Malnutrition

    V. Systemic Reactions Induced by Drug-Food Incompatibilities

    VI. Adverse Effects of Food Constituents on Nutrient Availability

    VII. Nutrient-Nutrient Incompatibilities

    VIII. Summary and Conclusions

    IX. Research Needs


    12 Ascorbic Acid and Drug Metabolism

    I. Introduction

    II. In Vivo Effects of Ascorbic Acid

    III. Specificity Studies

    IV. In Vivo Reversal of Drug Metabolism and Cytochrome Ρ-450 Turnover in Deficient Guinea Pigs

    V. Drug-Cytochrome P-450 Binding and Km Studies

    VI. Lipid Peroxidation and Phosphatidylcholine in Normal and Deficient Animals

    VII. Comparative Physicochemical Properties of Cytochrome P-450 in Normal and Ascorbic Acid-Deficient Microsomes

    VIII. Research Needs


    13 Dietary Minerals and Drug Metabolism

    I. Introduction

    II. Essential Minerals

    III. Nonessential Minerals

    IV. Conclusion and Research Needs


    14 Drug Metabolism and Infantile Undernutrition

    I. Introduction

    II. Antipyretic Drug Metabolism

    III. Metabolism of Antibiotics

    IV. Summary and Conclusions


    15 Effects of Dietary Protein on Drug Metabolism

    I. Introduction

    II. Effect of Protein Deficiency on Mixed-Function Oxidase Enzyme System

    III. Conclusions


    16 Effect of Amino Acid Intake on Ethanol Toxicity

    I. Introduction

    II. Ethanol Absorption and Metabolism

    III. Acute and Chronic Toxicity of Ethanol

    IV. Methods of Determining Ethanol Toxicity

    V. Role of Acetaldehyde in Alcohol Toxicity

    VI. Summary


    17 Nutritional Effects on Drug-Protein Binding

    I. Introduction

    II. Binding to Plasma Albumin

    III. Free Fatty Acids

    IV. Effects of Free Fatty Acids on Drug Binding to Plasma Albumin

    V. Mechanism of Fatty Acid-Induced Albumin Binding Changes

    VI. Summary and Conclusions

    VII. Research Needs


    18 Lipids in Drug Detoxication

    I. Introduction

    II. Function of Lipoprotein in the Drug-Metabolizing Enzyme System

    III. Effect of Dietary Lipid on Composition of Hepatic Endoplasmic Reticulum

    IV. Role of Dietary Lipid in Hepatic Microsomal Drug Metabolism

    V. Role of Dietary Lipid on Component Enzymes of Drug-Metabolizing System

    VI. Effect of Dietary Lipid on Substrate Interaction with Cytochrome P-450

    VII. Effect of Dietary Lipid on Intestinal Mixed-Function Oxidase Activity

    VIII. Effect of Dietary Lipid on the Induction of Hepatic Drug Metabolizing Enzymes


    19 Dietary Effects on Carcinogenicity of Drugs and Related Compounds

    I. Introduction

    II. Review

    III. Antitumor Agents

    IV. Steroid Hormones

    V. Agents Active in the Nervous System

    VI. Antibacterial and Antiparasitic Agents

    VII. Agents for Treatment of Dermatologic Diseases

    VIII. Discussion


    Section III / Use of Drugs in Animal Feeds

    20 The Role of Antibiotics in Efficient Livestock Production

    I. Introduction

    II. Mode of Action

    III. Continued Effectiveness

    IV. Application of Antibiotics in Feeding Programs

    V. Summary


    21 Physiological Effects of Estrogens in Animal Feeds with Emphasis on Growth of Ruminants

    I. Introduction

    II. Plant Estrogens

    III. Estrogens of Mycological Origin

    IV. Synthetic Estrogens

    V. Overview


    22 Distribution and Fate of Growth-Promoting Drugs Used in Animal Production

    I. Introduction

    II. Compounds Possessing Hormonal Activity

    III. Antibiotics

    IV. Arsenic-Containing Compounds

    V. Conclusions


    23 Antibiotics in Animal Feeds: An Assessment of the Animal and Public Health Aspects

    I. Introduction

    II. Relevant New Information

    III. Conclusions


    Section IV / Use of Nutrients and Foods as Drugs

    24 Some Aspects of Pharmacologic Use and Abuse of Water-Soluble Vitamins

    I. Review of Vitamins

    II. Nicotinic Acid

    III. Vitamin C

    IV. Conclusions


    25 Uses and Function of Vitamin Κ

    I. Historical Sketch

    II. Blood Coagulation Mechanisms

    III. Role of Vitamin K-Dependent Proteins

    IV. Inactivation of Vitamin K-Dependent Proteins by Antithrombin III

    V. A Fifth Vitamin K-Dependent Protein

    VI. Depression of Vitamin Κ Activity

    VII. Vitamin Κ Function and the Structure of Prothrombin

    VIII. Five Distinct Vitamin K-Dependent Molecules

    IX. Some Possibilities and Needs for Investigation


    26 Vitamin D: Metabolism, Drug Interactions, and Therapeutic Applications in Humans

    I. Introduction

    II. Metabolism of Vitamin D

    III. Biochemical Mode of Action of 1,25-Dihydroxyvitamin D

    IV. Drug and Disease-Related Aberrations in Vitamin D Metabolism and Therapeutic Application of Vitamin D-Sterols

    V. Calcinogenic Plants as a Source of 1,25-Dihydroxyvitamin D3

    VI. Perspectives in Future Vitamin D Research


    27 Toxic Effects of Megadoses of Fat-Soluble Vitamins

    I. Introduction

    II. Hypervitaminosis A

    III. Excess Vitamin Ε

    IV. Toxicity of Vitamin Κ

    V. Interactions of Hypervitaminoses

    VI. Research Needs


    28 Diet and Drug Therapy of Hyperlipoproteinemia

    I. Introduction

    II. Atherosclerosis and Hyperlipoproteinemia

    III. Hyperlipoproteinemia

    IV. Dietary Therapy of Hyperlipoproteinemia

    V. Drug Therapy

    VI. Research Needs


    29 Medicinal Uses of Foods

    I. Introduction

    II. Vegetable, Animal, and Mineral Prescriptions and Uses

    III. Diets

    IV. Conclusion


    Author Index

    Subject Index

Product details

  • No. of pages: 948
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323141970

About the Editor

John Hathcock

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