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Nucleic Acids as Gene Anticancer Drug Delivery Therapy - 1st Edition - ISBN: 9780128197776, 9780128197783

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

1st Edition

Author: Loutfy H. Madkour
Paperback ISBN: 9780128197776
eBook ISBN: 9780128197783
Imprint: Academic Press
Published Date: 15th August 2019
Page Count: 650
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Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

Key Features

  • Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery
  • Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations
  • Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy


Researchers and advanced students performing interdisciplinary research in nanomedical technologies addressing drug and nucleic acid/gene delivery to cancer as well as those in pharmaceutical sciences, biotechnology, and cancer research

Table of Contents

1. Advanced drug delivery systems: New nanomedication technologies
2. Characteristics of deoxyribonucleic acid
3. Characteristics of ribonucleic acid
4. Clinical applications of nucleic acid (DNA) gene therapeutics delivery systems
5. Therapeutic applications of siRNA gene delivery systems
6. Targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy
7. Classifications of DNA binding molecules - Drug interactions
8. Structures of quadruplex nucleic acids and their drug complexes
9. Solvent-accessible surfaces of proteins and nucleic acids
10. Nucleic acid medicines as green novel anticancer drugs
11. Correlation between nucleic acids and nanoparticle therapeutics for cancer treatment
12. Drug delivery systems as advanced nanotechnology
13. Nanoparticle and polymeric nanoparticle-based targeted drug delivery systems
14. Polymer nanoparticle drug-nucleic acid combinations
15. Combinational delivery therapies of nucleic acids for cancer treatment
16. Multiple delivery of drug-nucleic acid combinations for cancer treatment
17. FDA and the medical device clinical drug trials
18. Biological barriers to cancer drug delivery, efficacy and cancer models
19. Toxicological considerations of clinically applicable nanoparticles
20. DNA complexes as an efficient gene anticancer drug delivery therapy
21. Immunotherapy with mRNA vaccination and immunomodulation nanomedicine for cancer therapy


No. of pages:
© Academic Press 2020
15th August 2019
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

Loutfy H. Madkour

Dr. Loutfy H. Madkour is a professor of physical chemistry and nanoscience at the Chemistry Department, Faculty of Science, Al Baha University, Saudi Arabia, since 2012. He received his BSc, MSc, and PhD degrees in physical chemistry from the universities of Cairo, Minia, and Tanta, respectively, in Egypt. He worked as a lecturer in chemistry at the Tanta University since 1982 and as a professor of physical chemistry in 1999. He is an editorial board member of several international journals including International Journal of Industrial Chemistry (IJIC), International Journal of Ground Sediment & Water, E-Cronicon Chemistry (EC Chemistry), BAOJ Chemistry, Global Drugs and Therapeutics (GDT), Chronicles of Pharmaceutical Science, and Journal of Targeted Drug Delivery.

Affiliations and Expertise

Chemistry Department, Faculty of Science, Al Baha University, Saudi Arabia

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