Nuclear Trafficking

Nuclear Trafficking

1st Edition - July 6, 1992

Write a review

  • Editor: Carl Feldherr
  • eBook ISBN: 9780323152983

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Nuclear Trafficking is a summary of the state of knowledge in nuclear trafficking, and is organized into five parts. The book begins by discussing the diffusion and signal-mediated transport through the pores. It then looks into the detailed accounts of pore structure and composition, nuclear localization signals, signal binding proteins, RNA efflux, and biochemical factors influencing nucleocytoplasmic exchange. This book will be very useful to those people new to this field of interest.

Table of Contents

  • Contributors


    I Molecular Exchanges across the Nuclear Envelope

    1 Diffusion between Nucleus and Cytoplasm

    I. Introduction

    II. Permeability of Nuclear Envelope

    III. Biophysical State of Transported Molecules

    IV. Kinetics and Equilibria of Diffusion


    2 Overview of Signal-Mediated Transport

    I. Introduction

    II. Signal-Mediated Transport

    III. Composition of Pores

    IV. Regulation of Nucleocytoplasmic Exchange

    V. Concluding Comments


    II Structural Organization of Pores and Associated Skeletal Elements

    3. The Nuclear Pore Complex: A Macromolecular Transporter

    I. Introduction and Background

    II. Triple Ring Model of the Nuclear Pore Complex

    III. Symmetry of the Nuclear Pore Complex: A Question of Resolution and Semantics

    IV. Components of the Nuclear Pore Complex: Modality and Function

    V. Nuclear Pore Complex and Transport

    VI. Concluding Remarks


    4. Regulation of Nucleocytoplasmic Transport by Mechanical Forces Transmitted through the Cytoskeleton

    I. Introduction

    II. Nuclear Pore Complex

    III. Regulation of Nucleocytoplasmic Transport

    IV. Linkages between Nuclear Pore Complex and Nuclear Matrix-Cytoskeletal Network

    V Possible Use of a Tensegrity (Tensional Integrity) Mechanism for Regulation of Nucleocytoplasmic Transport

    VI. Conclusion


    III Molecular Aspects of Nuclear Trafficking

    5 Structure and Regulation of Nuclear Localization Signals

    I. Introduction

    II. Suggestions of Nuclear Localization Signal

    III. Molecular Biology of Nuclear Localization Signals

    IV. Redundant Nuclear Localization Signals

    V. Complex Nuclear Localization Signals

    VI. Regulation of Nuclear Localization Signal Function

    VII. Concluding Remarks


    6 Nuclear Transport Receptors: Specificity amid Diversity

    I. Nuclear Transport: Overview

    II. Functional Characteristics of Nuclear Transport Receptors

    III. Identification of Nuclear Transport Receptor Candidates

    IV. Future Directions


    7 Structure and Function of Nuclear Pore Glycoproteins

    I. Introduction

    II. Nuclear Pore Complex Proteins

    III. Functional Studies of Nucleoporins

    IV. Conclusions


    8 Nuclear Pore Complex-Associated ATPase

    I. Introduction: Nuclear Envelope

    II. Nuclear Pore Complex

    III. Myosin-like ATPase Associated with Nuclear Pore Complex

    IV. Conclusions and Prospects for Future Research


    IV RNA Transport

    9 Role of mRNA Transport in Posttranscriptional Control of Gene Expression

    I. Overview

    II. Role of Posttranscriptional Control in Regulation of Gene Expression

    III. Posttranscriptional Processing of Primary Transcript

    IV. Nuclear Matrix

    V. Relationship between Pre-mRNA Splicing and mRNA Transport

    VI. Transport across Nuclear Envelope

    VII. Conclusions and Future Prospects


    10 Transport of Ribosomal Proteins and rRNA, tRNA, and snRNA

    I. Introduction

    II. Overview of Ribosome Assembly in Nucleated Cells

    III. Nuclear Localization of Ribosomal Proteins

    IV. Nuclear Export of Ribosomal Subunits

    V. Transport of 5 S rRNA

    VI. Transport of tRNA

    VII. Trafficking of snRNPs

    VIII. Export of Other Small RNAs

    IX. Concluding Remarks


    V Biophysical Considerations

    11 Biophysics of Nucleocytoplasmic Transport

    I. Introduction

    II. Cytoplasm

    III. Near Nuclear Envelope

    IV. Nuclear Pore Complex

    V. Nuclear Interior

    VI. Kinetics and Steady State of Transport



Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: July 6, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9780323152983

About the Editor

Carl Feldherr

Ratings and Reviews

Write a review

There are currently no reviews for "Nuclear Trafficking"