Nuclear Particles

Nuclear Particles

The Cell Nucleus, Vol. 8

1st Edition - January 28, 1981

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  • Editor: Harris Busch
  • eBook ISBN: 9781483216805

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The Cell Nucleus, Volume III: Nuclear Particles, Part A covers topics on "splicing" and "processing" and on the controls of transcriptional and transport events that must be essential to cells that are either growing and/or are phenotypically differentiated. The book discusses the immunolocalization and structural organization of nascent RNP; the in situ localization of RNA structures; and the morphogenesis, cytochemistry, and putative role of perichromatin granules. The text describes transcription in the isolated nuclei; the isolation and structure of the ribonucleoprotein fibrils containing heterogeneous nuclear RNA; and low-molecular-weight nuclear ribonucleoprotein particles. The sequence, function, and role of U snRNAs of nuclear snRNPs; the maturation of low-molecular-weight RNA species; and the properties of the heterogeneous nuclear RNA-protein complexes and nuclear matrix are also encompassed. The book further tackles human antibodies to RNA-containing particles. Cellular biologists, microbiologists, pharmacologists, geneticists, and students taking related courses will find the book useful.

Table of Contents

  • Contributors


    Contents of Other Volumes

    Chapter 1 Immunolocalization and Structural Organization of Nascent RNP

    I. Introduction

    II. Transcriptional Activities

    III. Interaction of Nascent RNA Transcripts with Proteins

    IV Immunological Studies on Nascent RNP Transcripts

    V Ultrastructural Analysis of Nascent RNP Transcripts

    VI. Functional Activities of Nascent RNP Transcripts


    Chapter 2 In Situ Localization of RNA Structures

    I. Introduction

    II. Methods in Ultrastructural Detection of RNA

    III. General Organization of Nuclear RNA Structures

    IV The Border of Condensed Chromatin

    V. RNA Structures Present in the Interchromatin Space

    VI. The Nucleolus

    VII. Conclusions


    Chapter 3 Perichromatin Granules

    I. Introduction

    II. Morphogenesis and Fine Structure of the PCG's

    III. Variations in the Number of PCG's

    IV. Cytochemistry of PCG's in Situ

    V. Isolation of the PCG's

    VI. Putative Role of the PCG's


    Chapter 4 Transcription in Isolated Nuclei

    I. Introduction

    II. Techniques for Isolating Nuclei

    III. Transcription in Isolated Nuclei

    IV. Modification of Transcriptional Activity

    V. Conclusions


    Chapter 5 Isolation and Structure of the Ribonucleoprotein Fibrils Containing Heterogeneous Nuclear RNA

    I. Introduction

    II. Isolation of hnRNP

    III. The Two Classes of Units of hnRNP

    IV. The Constituents of hnRNP

    V. Conclusions


    Chapter 6 Low-Molecular-Weight Nuclear Ribonucleoprotein Particles

    I. Introduction

    II. Isolation and Characterization of Low-Molecular-Weight Nuclear RNP's Containing snRNA Species (snRNP's)

    III. The Presence of snRNA in hnRNP Complexes

    IV. Relation of the 10 S snRNP Particles to 30-50 S Structures

    V. Poly(A)-Containing Low-Molecular-Weight Nuclear RNP Particles

    VI. Biological Role of snRNP's

    VII. Conclusions


    Chapter 7 U snRNA's of Nuclear snRNP's

    I. Introduction

    II. Primary Sequence of snRNA's

    III. Other Studies on snRNA's

    IV. Functions of snRNA's

    V. Structural Homologies of snRNA's


    Chapter 8 Maturation of Low-Molecular-Weight RNA Species

    I. Introduction

    II. Maturation


    Chapter 9 Heterogeneous Nuclear RNA- Protein Complexes and Nuclear Matrix

    I. Introduction

    II. Properties of hnRNA-Protein Complexes

    III. Heterogeneous Nuclear RNA and Small-Molecular-Weight RNA

    IV. Proteins in nRNP Complexes

    V. nRNP Complexes and Nuclear Matrix

    VI. Models

    VII. Conclusion and Prospects


    Chapter 10 Human Antibodies to RNA-Containing Particles

    I. Introduction

    II. Ribosomes

    III. Nucleoli

    IV. Nuclear RNP Particles



Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9781483216805

About the Editor

Harris Busch

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