Novel Psychoactive Substances

Novel Psychoactive Substances

Classification, Pharmacology and Toxicology

1st Edition - August 6, 2013

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  • Editors: Paul Dargan, David Wood
  • Hardcover ISBN: 9780124158160
  • eBook ISBN: 9780124159112

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Description

Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

Key Features

  • Includes chapters written by international experts in the field.
  • Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance.
  • Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies.
  • Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in ‘spice’ / ‘K2’.

Readership

Research scientists and academics in pharmacology and toxicology, biochemists and healthcare professionals, including physicians, nurses and paramedics, law enforcement and legislative authorities.

Table of Contents

  • Forewords

    List of Contributors

    Section 1: Background

    Chapter 1. Legal Classification of Novel Psychoactive Substances: An International Comparison

    Introduction

    Traditional Control Mechanisms

    Recent Developments

    References

    Chapter 2. Monitoring Novel Psychoactive Substances: A Global Perspective

    Introduction

    Definitions

    The Identification, Risk Assessment and Monitoring of Novel Psychoactive Substances

    The EU Ews Information Exchange

    International, Regional and National Drug Monitoring Systems

    Sources for Detecting and Monitoring Novel Psychoactive Substances

    Conclusions

    References

    Chapter 3. Availability and Supply of Novel Psychoactive Substances

    Background

    Novel Psychoactive Substance Market

    NPS Origins and Market Entry

    NPS Market Structure

    Products

    Conclusions

    References

    Chapter 4. Epidemiology of Use of Novel Psychoactive Substances

    Introduction

    General Population Surveys

    Summary and Conclusions

    References

    Chapter 5. Social Issues in the Use of Novel Psychoactive Substances: Differentiated Demand and Ideological Supply

    Introduction

    Availability

    Prevalence in Context: Differentiated Demand in Different Leisure Venues

    Understanding Motivations: The Displacement Question

    Exploring Social Harms: Legislative Control and the Supply of NPS

    Policy Options in a Changing World

    The NPS Debate: Historical Stagnation and Vested Interests (A UK Perspective)

    Conclusion

    References

    Section 2: Analytical Techniques

    Chapter 6. Analytical Techniques for the Detection of Novel Psychoactive Substances and Their Metabolites

    Introduction

    Analytical Methods Covering Several Classes of Novel Psychoactive Substances

    Methods for Screening and/or Quantification of Novel Psychoactive Substances from Specific Drug Classes

    Recommendations for Setting up Analytical Methods for Analysis of Novel Psychoactive Substances

    References

    Section 3: Individual Novel Psychoactive Substances

    Chapter 7. Synthetic Amphetamine Derivatives

    Pharmacology

    Monomethoxy Derivatives

    Dimethoxy Derivatives

    Trimethoxy Derivatives

    Thiol-Derivatives

    4-Fluoroamphetamine

    Monomethyl Derivatives

    Summary

    References

    Chapter 8. 1-Benzylpiperazine and other Piperazine-based Derivatives

    Introduction

    Pharmacology

    Toxicology

    Treatment

    Chronic Toxicity

    Dependence and Abuse Potential

    Conclusion

    Acknowledgment

    References

    Chapter 9. Mephedrone

    Introduction

    Pharmacology

    Prevalence of Use

    Acute Toxicity

    Mephedrone-Related Deaths

    Chronic Toxicity

    Dependence and Abuse Potential

    References

    Chapter 10. Pipradrol and Pipradrol Derivatives

    Pharmacology

    Prevalence of Use

    Acute Toxicity

    Chronic Toxicity

    Dependence and Abuse Potential

    Conclusions

    References

    Chapter 11. Aminoindane Analogues

    Introduction

    Pharmacology

    Prevalence of Use

    Regulation of the Aminoindanes

    Acute and Chronic Toxicity

    Dependence and Abuse Potential

    Conclusions

    References

    Chapter 12. Ketamine

    Introduction

    Pharmacology and Animal Models of Ketamine Toxicity

    Physical and Chemical Description

    Acute Toxicity

    Chronic Toxicity

    Dependence and Abuse Liability

    References

    Chapter 13. Synthetic Cannabinoid Receptor Agonists

    Introduction

    Pharmacology

    Prevalence of Use

    Acute Toxicity

    Chronic Toxicity

    Dependence and Abuse Potential

    Forensic Relevance

    Conclusions

    References

    Chapter 14. Natural Product (Fungal and Herbal) Novel Psychoactive Substances

    Introduction

    Fungal NPS

    Conclusions

    Acknowledgments

    References

    Chapter 15. Tryptamines

    Tryptamines

    Pharmacology

    Prevalence of Use

    Acute Toxicity

    Chronic Toxicity

    Dependence and Abuse Potential

    Conclusions

    References

    Chapter 16. Benzofurans and Benzodifurans

    Benzofurans

    Pharmacology

    Prevalence of Use

    Acute Toxicity

    Chronic Toxicity

    Dependence and Abuse Potential

    References

    Chapter 17. Miscellaneous Compounds

    Methoxetamine

    Dimethylamylamine (DMAA)

    Synthetic Cocaines

    References

    Index

Product details

  • No. of pages: 440
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: August 6, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124158160
  • eBook ISBN: 9780124159112

About the Editors

Paul Dargan

Professor Dargan and Dr Wood are both expert advisors on novel psychoactive substances to expert bodies in the UK (Advisory Council on the Misuse of Drugs, ACMD), Europe (European Monitoring Centre for Drugs and Drug Addiction, EMCDDA) and Worldwide (United Nations Office on Drugs and Crime, UNODC). They run a clinical service managing patients with acute drug toxicity, and have a clinical and research interest in novel psychoactive substances. They publish widely in this field and have both been invited to give keynote lectures at International meetings on this topic.

Affiliations and Expertise

Consultant Physician and Professor of Clinical Toxicology, London, UK

David Wood

David Wood is a Consultant Physician and Clinical Toxicologist at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Affiliations and Expertise

Consultant Physician and Clinical Toxicologist, Reader in Clinical Toxicology, London, UK

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