Nonhuman Primates and Medical Research

Nonhuman Primates and Medical Research

1st Edition - January 1, 1973

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  • Editor: Geoffrey H. Bourne
  • eBook ISBN: 9781483258041

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Nonhuman Primates and Medical Research focuses on the contributions of nonhuman primates to biomedical research. The selection first elaborates on monkeys and yellow fever, cell cultures, and tuberculosis and bacterial infection. Discussions focus on bacterial diseases, tuberculosis, radiobiology, antibody formation and pharmacologic studies, cell-culture media and methods, the rhesus monkey and early history of yellow fever research, and monkeys and yellow fever in the future. The text then elaborates on virus research, models for investigation in parasitology, and primates as organ donors in transplantation studies in man. The manuscript examines the importance of monkeys for the study of malignant tumors in man; use of primates in cardiovascular research; and humanlike diseases in anthropoid apes. Topics include etiology of humanlike disease in anthropoid apes, atherosclerosis, historical aspects of primate research, selection of a suitable primate, and preeclampsia. The text also ponders on primate studies and human evolution and mental retardation. The selection is a valuable reference for researchers interested in the contributions of nonhuman primates to biomedical research.

Table of Contents

  • List of Contributors


    Chapter 1. Monkeys and Yellow Fever

    I. The Rhesus Monkey and Early History of Yellow Fever Research

    II. The Role of the New World Monkeys in Yellow Fever Research

    III. Monkeys and Yellow Fever in the Future


    Chapter 2. Monkeys and Malaria



    Chapter 3. Cell Cultures

    I. Cell-Culture Media and Methods

    II. Cells Suitable for Cultivation

    III. Interaction Between Cell Cultures and Parasites

    IV. Antibody Formation and Pharmacologic Studies

    V. Radiobiology

    VI. Discussion


    Chapter 4. Tuberculosis and Bacterial Infection

    I. Introduction

    II. Tuberculosis

    III. Bacterial Diseases

    IV. Summary


    Chapter 5. Virus Research

    I. Introduction

    II. Early Virus Research—Prior to 1950

    III. Current Virus Research in Monkeys

    IV. Diseases—Natural and Experimental

    V. Conclusions and Perspectives


    Chapter 6. Models for Investigation in Parasitology

    I. Introduction

    II. Protozoa

    III. Helminths

    IV. Pentastomida

    V. Status of Nonhuman Primate Parasitology


    Chapter 7. Primates as Organ Donors in Transplantation Studies in Man

    I. Introduction

    II. Historical Perspective

    III. Clinical Aspects of Renal Heterotransplantation

    IV. Immunologic Studies in Renal Heterotransplantation

    V. Pathology of Renal Heterotransplantation

    VI. Implications of Heterotransplantation


    Chapter 8. The Importance of Monkeys for the Study of Malignant Tumors in Man



    Chapter 9. The Use of Primates in Cardiovascular Research

    I. Introduction

    II. Historical Aspects of Primate Research

    III. The Selection of a Suitable Primate

    IV. The Rhesus Monkey

    V. The Baboon

    VI. The Squirrel Monkey

    VII. The Chimpanzee

    VIII. Other Aspects of Cardiovascular Research in Primates


    Chapter 10. Humanlike Diseases in Anthropoid Apes

    I. Introduction

    II. Materials and Methods

    III. Atherosclerosis

    IV. Preeclampsia

    V. Essential Hypertension

    VI. Ulcerative Colitis

    VII. Etiology of Humanlike Diseases in Anthropoid Apes

    VIII. Significance of These Findings

    IX. Conclusions


    Chapter 11. Cross-Circulation between Humans in Hepatic Coma and Chimpanzees

    I. Introduction

    II. Cross-Circulation Using Yerkes Chimpanzees

    III. Effect of the Cross-Circulation Procedure on the Chimpanzee

    IV. The Second Cross-Circulation

    V. Discussion

    VI. Summary and Conclusions


    Chapter 12. The Cape Chacma Baboon in Surgical Research

    I. Mitral-Valve Replacement

    II. Cardiac Transplantation

    III. Corneal Transplantation

    IV. Lung Transplantation

    V. Auxiliary ex Vivo Extracorporeal Liver Perfusion and Hepatic Assist

    VI. Immunology and Immunosuppressive Therapy after Tissue Transplantation

    VII. Antilymphocyte Serum

    VIII. Drug Evaluation

    IX. Liver Transplantation

    X. Organ Preservation

    XI. Cardiodynamic Studies

    XII. Normal Anatomic and Physiologic Studies and Values

    XIII. Handling

    XIV. Conclusions


    Chapter 13. Degenerative Diseases

    I. Introduction

    II. General Considerations

    III. Aging

    IV. Diseases of the Circulatory System

    V. Gastrointestinal System

    VI. Urinary Tract

    VII. Respiratory System

    VIII. Nervous System

    IX. Endocrine System

    X. The Skeleton

    XI. Muscles

    XII. Skin

    XIII. Sensory Organs

    XIV. Conclusions


    Chapter 14. Modeling of Neurogenic Disease in Monkeys



    Chapter 15. Development of a Brain Prosthesis

    I. Introduction

    II. Programmed Stimulation of the Brain

    III. Experimental Prosthesis for Stroke

    IV. Multiple-Electrode Programmable Brain Stimulators

    V. Computer Programming and Control

    VI. Programmed Brain Stimulation for Visual Prosthesis

    VII. Conclusions and Future Possibilities


    Chapter 16. Visual Refractive Characteristics and the Subhuman Primate

    I. Introduction

    II. Comparative Visual Refractive Characteristics of Human and Subhuman Primates

    III. The Development of Visual Refractive Characteristics

    IV. The Role of Heredity in the Development of Visual Refractive Characteristics

    V. The Role of Environment in the Development of Visual Refractive Characteristics

    VI. Conclusions


    Chapter 17. Contribution of Primate Research to Sensory Physiology

    I. Studies in the Somatosensory System

    II. Studies of the Visual System in Primates

    III. Correlative Studies of Psychophysics and Neurophysiology

    IV. Studies of Sensory Perception in Primates


    Chapter 18. Performance Studies in Biomedical Research



    Chapter 19. The Importance of Nonhuman Primate Studies of Learning and Related Phenomena for Understanding Human Cognitive Development

    I. Learning Set Skills

    II. Transfer Skills

    III. Extinction

    IV. Attention and Meditational Deficits

    V. Changes in Learning Processes


    Chapter 20. Mental Retardation

    I. Introduction and Definition

    II. Individual Differences

    III. Genetic Factors

    IV. Ontogenetic Factors

    V. Summary


    Chapter 21. Primate Studies and Human Evolution

    I. New Methods

    II. Field Studies

    III. Anatomy

    IV. Counting the Differences

    V. Adaptive Complexes

    VI. Paleontology

    VII. Parallelism

    VIII. Conclusions


    Chapter 22. The Primate Research Center Program of the National Institutes of Health

    Research in the Primate Centers


    Subject Index

Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9781483258041

About the Editor

Geoffrey H. Bourne

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