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Neurotransmitters - 1st Edition - ISBN: 9780080231921, 9781483154756


1st Edition

Proceedings of the 7th International Congress of Pharmacology, Paris, 1978

Editor: P. Simon
eBook ISBN: 9781483154756
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 312
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Advances in Pharmacology and Therapeutics, Volume 2: Neurotransmitters contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neurotransmitters, their pharmacology, and their therapeutic applications. Topics covered range from the functions of GABA to the interdependence of neurotransmitter systems in the central nervous system (CNS). This volume is comprised of 24 chapters and opens with a discussion on the role of GABA systems in Huntington's disease and schizophrenia. The reader is then introduced to the stereospecific actions of GABA analogues; interactions between serotonin and noradrenalin containing neurons; immunofluorescent staining of serotonin in the CNS; and plasticity of transmitter functions in sympathetic neurons developing in cell culture. The following chapters explore the molecular mechanisms underlying the modulation of catecholamine release from the adrenal medulla; pre-and postsynaptic regulation of catecholamine neurotransmitters; the role of GABA-ergic component in the mechanism of action of neurotropic drugs; and pre-and postsynaptic action of GABA in the mammalian spinal cord. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents


GABA: Simple Molecule with Complex Functions

GABA Systems in Human Brain in Huntington's Disease and Schizophrenia

Stereospecific Actions of GABA Analogues

Barbiturates, Benzodiazepines and the GABA System

Kinetics of GABA Action at the Crayfish Neuromuscular Junction

A Molecular Mechanism for the Action of Benzodiazepines on GABA-Ergic Transmission

Toward a Rational Pharmacology of the GABA System

Interdependence of Neurotransmitter Systems in the CNS

Physiology and Pharmacology of Ganglionic Synapses as Models for Central Transmission

Microphysiological and Pharmacological Studies on Transmitters in the Substantia nigra

Studies of the Interdependence of Neurotransmitter Systems by Micro-Biochemical Approaches

Role of Various Nigral afferences on the Activity of the Nigrostriatal Dopaminergic Pathways

Interactions between Serotinin and Noradrenalin Containing Neurons: Link Between The Raphe System and the Locus coeruleus

Histochemistry of Transmitter Interactions — Neuronal Coupling and Coexistence of Putative Transmitters

Concluding Remarks

Pharmacology of Neurotransmitters: New Vistas

Immunofluorescent Staining of Serotonin in the Central Nervous System

Excitatory Amino Acids: Receptor Differentiation by Selective Antagonists and Role in Synaptic Excitation

Histaminergic Systems in Brain

The Action of Substance P on Motoneurons of the Isolated Rat Spinal Cord

Plasticity of Transmitter Functions in Sympathetic Neurons Developing in Cell Culture

Is There a Neurotransmitter Code in the Brain

Invited Lectures

Molecular Mechanisms in the Modulation of Catecholamine Release from the Adrenal Medulla

Some Structural Features of Amine Uptake Mechanisms

Pre- and Postsynaptic Regulation of Catecholamine Neurotransmitters

GABA-Ergic Component in the Mechanism of Action of Neurotropic Drugs

Pre- and Postsynaptic Action of GABA in the Mammalian Spinal Cord



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© Pergamon 1979
1st January 1979
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About the Editor

P. Simon

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