Proceedings of the 7th International Congress of Pharmacology, Paris, 1978

1st Edition - January 1, 1979

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  • Editor: P. Simon
  • eBook ISBN: 9781483154756

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Advances in Pharmacology and Therapeutics, Volume 2: Neurotransmitters contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neurotransmitters, their pharmacology, and their therapeutic applications. Topics covered range from the functions of GABA to the interdependence of neurotransmitter systems in the central nervous system (CNS). This volume is comprised of 24 chapters and opens with a discussion on the role of GABA systems in Huntington's disease and schizophrenia. The reader is then introduced to the stereospecific actions of GABA analogues; interactions between serotonin and noradrenalin containing neurons; immunofluorescent staining of serotonin in the CNS; and plasticity of transmitter functions in sympathetic neurons developing in cell culture. The following chapters explore the molecular mechanisms underlying the modulation of catecholamine release from the adrenal medulla; pre-and postsynaptic regulation of catecholamine neurotransmitters; the role of GABA-ergic component in the mechanism of action of neurotropic drugs; and pre-and postsynaptic action of GABA in the mammalian spinal cord. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents

  • Introduction

    GABA: Simple Molecule with Complex Functions

    GABA Systems in Human Brain in Huntington's Disease and Schizophrenia

    Stereospecific Actions of GABA Analogues

    Barbiturates, Benzodiazepines and the GABA System

    Kinetics of GABA Action at the Crayfish Neuromuscular Junction

    A Molecular Mechanism for the Action of Benzodiazepines on GABA-Ergic Transmission

    Toward a Rational Pharmacology of the GABA System

    Interdependence of Neurotransmitter Systems in the CNS

    Physiology and Pharmacology of Ganglionic Synapses as Models for Central Transmission

    Microphysiological and Pharmacological Studies on Transmitters in the Substantia nigra

    Studies of the Interdependence of Neurotransmitter Systems by Micro-Biochemical Approaches

    Role of Various Nigral afferences on the Activity of the Nigrostriatal Dopaminergic Pathways

    Interactions between Serotinin and Noradrenalin Containing Neurons: Link Between The Raphe System and the Locus coeruleus

    Histochemistry of Transmitter Interactions — Neuronal Coupling and Coexistence of Putative Transmitters

    Concluding Remarks

    Pharmacology of Neurotransmitters: New Vistas

    Immunofluorescent Staining of Serotonin in the Central Nervous System

    Excitatory Amino Acids: Receptor Differentiation by Selective Antagonists and Role in Synaptic Excitation

    Histaminergic Systems in Brain

    The Action of Substance P on Motoneurons of the Isolated Rat Spinal Cord

    Plasticity of Transmitter Functions in Sympathetic Neurons Developing in Cell Culture

    Is There a Neurotransmitter Code in the Brain

    Invited Lectures

    Molecular Mechanisms in the Modulation of Catecholamine Release from the Adrenal Medulla

    Some Structural Features of Amine Uptake Mechanisms

    Pre- and Postsynaptic Regulation of Catecholamine Neurotransmitters

    GABA-Ergic Component in the Mechanism of Action of Neurotropic Drugs

    Pre- and Postsynaptic Action of GABA in the Mammalian Spinal Cord


Product details

  • No. of pages: 312
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483154756

About the Editor

P. Simon

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