Neurotransmitter Release: The Neuromuscular Junction is a collection of papers presented at a small meeting organized in the University of Milan to honor Bruno Ceccarelli. Ceccarelli was particularly interested in the structure and functioning of the neuromuscular junction and spent the rest of his career characterizing the process of neurotransmitter release, and eventually providing the strongest available support for the widely accepted ""vesicle hypothesis"" of neurotransmitter release. The meeting was intended to gather as many scientists who had been directly in touch with Bruno as possible and to discuss together problems of Bruno's interest.
Organized into 20 chapters, the book first discusses the organelles of distinct secretory pathways involved in distinct types of neuronal signaling, such as synapsins, synaptophysin , and synaptobrevin. It then examines the role of coated vesicles, acetylcholine compartments, and potassium and calcium channels on neurotransmission processes. Other topics considered are the regeneration of nerve-evoked neurotransmission; the single-channel recordings of KNa in avian sensory neurons; the modulation of voltage-dependent calcium currents in identified snail neurons; and the agonistic/antagonistic action of calcium channel in mammalian peripheral neurons. Cross-talks between receptors coupled to calcium currents and between different intracellular signaling are provided in the last chapters of the book. These chapters also look into the relevance of lipoxygenase metabolites of arachidonic acid to cell-to-cell communication in the central nervous system.
This book is an invaluable source for scientists, researchers, and students who are interested in basic neurology.
Contributors Preface Letter by Alex Mauro Secretory Organelles of Neurons and their Relationship to Organelles of Other Cells The Synaptic Vesicle Membrane: Origin, Axonal Distribution, Protein Components, Exocytosis and Recycling Synapsin I, a Neuron Specific Phosphoprotein Interacting with Small Synaptic Vesicles and F-actin Synaptophysin and Synapsin I as Tools for the Study of the Exo-endocytotic Cycle Vasoactive Intestinal Polypeptide (VIP) as a Cholinergic Co-Transmitter: Some Recent Results The Correlation between Vesicle Loss and Quantal Secretion at the Frog Neuromuscular Junction The Role of Coated Vesicles in Recycling of Synaptic Vesicle Membrane Acetylcholine Compartments in Skeletal Muscle Dual Effect of Potassium on Transmitter Exocytosis Characterization of a Polyclonal Antiserum Raised Against Mediatophore, A Protein that translocates acetylcholine Presynaptic Regulation of Acetylcholine Release in the CNS Spontaneous and Nerve-evoked Quantal Transmission in Regenerated Motor Terminals The Genetics of Type A Potassium Channels in Drosophila Melanogaster Sodium-activated Potassium Channel in Avian Sensory Neurons Intracellular Mechanism of Neurotransmitter-Induced Modulations of Voltage-Dependent Ca Current in Snail Neurons Action of Ca2+ Agonists/Antagonists in Mammalian Peripheral Neurons Cross-Talk between Receptors coupled to Calcium Currents in Adult but not Neonatal Rat Sensory Neurons Cross-Talk between Different Intracellular Signalling Pathways in the Rat Hippocampus Arachidonic Acid Metabolites as Mediators of Synaptic Modulation Destabilization of ionized Ca2+ Homeostasis in Excitatory Amino Acid Neurotoxicity: Antagonism by Glycosphingolipids
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- © Academic Press 1990
- 28th January 1990
- Academic Press
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