This book focuses on the exciting recent progress in restorative neurology and neuroscience. The book includes chapters on major neurodegenerative disorders of the brain and the visual system, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, macular degeneration, retinitis pigmentosa, glaucoma, spinal cord trauma, and multiple sclerosis. The primary goal of the book is to give an overview of new developments in translational research and in potential therapeutic strategies, including stem cell therapy, immunotherapy, gene therapy, pharmacotherapy, neuroprostheses and deep brain stimulation.

Key Features

* Provides the reader with a unique overview over all aspects of new advances in the therapy of neurological and psychiatric disorders * Covers all levels of biological organization including novel molecular and cellular targets, electrophysiological, anatomical and behavioural substrates of neurodegeneration and the application of whole brain in vivo imaging * Broad focus with contributions by the top scientists worldwide in the respective disciplines


neuroscientists psychologists psychiatrists basic and clinical researches in medical fields

Table of Contents

Section - Stem Cells Jeffrey Macklis - Boston, USA Stem cell recruitement in the adult cortex following spinal cord injury Scott Whittemore - Louisville, USA Application of embryonic stem cells in spinal cord repair Peter Burbach - Utrecht, The Netherlands Molecular programming of stem cells into mesodiencephalic dopaminergic neurons Ole Isacson - Belmont, USA Stem cell transplantation in Parkinson disease Robin Ali - London, UK Retinal repair by transplantation of photoreceptors Thomas Reh - Seattle, USA Efficient generation of retinal progenitor cells from human embryonic stem cells Maurice Curtis - Gotenborg, Sweden Discovery of a rostral migratory stream in the adult human brain Magdalena Götz - Munich, Germany Glial cells as stem cells ? a new view on reactive gliosis Urban Lendahl - Stockholm, Sweden Molecular regulation of stem cell differentiation Anders Björklund - Lund, Sweden Cell and gene therapy repair stategies for Parkinson disease Section Immunotherapy and vaccination therapy Roger Nitsch - Zurich, Switzerland Immunotherapy of Alzheimer's disease Cynthia Lemere, Boston, USA Developing novel immunogens for effective and safe Alzheimer disease vaccine Frank Baas - Amsterdam, the Netherlands Complement therapy promotes peripheral nerve regeneration Philip Popovich - Columbus, USA T-cell and macrophage involvement in neuroregeneration Hans van Noort - Rijswijk, The Netherlands Toll-like receptors in the CNS: implications for neurodegeneration and repair Section Gene Therapy Alan Harvey - Perth, Australia Gene therapy and transplantation in CNS repair: the visual system Raymond Bartu


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© 2009
Elsevier Science
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