Neuroscience of Nicotine - 1st Edition - ISBN: 9780128130353

Neuroscience of Nicotine

1st Edition

Mechanisms and Treatment

Editors: Victor Preedy
Paperback ISBN: 9780128130353
Imprint: Academic Press
Published Date: 1st March 2019
Page Count: 608
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Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse.

With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process.

Key Features

  • Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function
  • Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse
  • Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects


Advanced students and researchers in the areas of neuroscience, drug abuse, addiction, and pharmacology

Table of Contents

Part 1: General Aspects of Nicotine Usage
1. History of tobacco usage
2. Substance use disorders and the position of nicotine
3. Tobacco use in different countries
4. Smokeless tobacco use (to cover e cigarettes) and nicotine
5. Health risks of snus
6. Cigarette design and nicotine in smoke
7. Nicotine use in communities
8. Smoking and alkaloids with nicotinic-like effects
9. Gender and nicotine
10. Smoking behaviour in subjects with disease: a focus on HIV
11. The future of smoking

Part 2: Effects of Nicotine on Neurobiological Function and Features
12. Dopamine release in the striatum and nicotine
13. Ventral tegmental area dopamine neurons and nicotine
14. Neurology of nicotinic acetylcholine receptors and Parkinson's disease
15. Smoking and neurodegeneration and the role of nicotine
16. Prenatal nicotine exposure and neuronal progenitor cells
17. Postsynaptic nicotinic acetylcholine receptor subunits in neurons
18. Nicotine and mRNA in neurons

Part 3: Psychology and Behaviour
19. Psychiatric conditions and nicotine addiction: an overview
20. Nicotine use in attention deficit/hyperactivity disorder
21. Schizophrenia and nicotinic acetylcholine receptors in nicotine addiction
22. Nicotine and posttraumatic stress symptoms
23. High-risk smoking behaviors
24. Cigarette smoking and obsessive-compulsive features
25. Nicotine and the hypothalamic-pituitary-adrenal axis: Implications for psychology
26. Nicotine and appetite
27. Cues and cigarette-related images

Part 4: Pharmacology and Neuropharmacology
28. Nicotine dependence and the dopaminergic system
29. Metabolism of nicotine and cotinine (a metabolite of nicotine)
30. Alpha-7 nicotinic acetylcholine receptors and pain
31. p38-dependent effects of nicotine and tau
32. Nicotine and metabotropic glutamate receptor-5
33. 18-Methoxycoronaridinand, medial habenula and sensitization to nicotine
34. Pharmacology of muscle-type nicotinic receptors
35. Role of nicotinic receptors and synaptic plasticity
36. Agonists and allosteric modulators of the alpha7 nicotinic ACh receptor

Part 5: Withdrawal and Craving
37. fMRI neurofeedback and craving in nicotine dependence
38. N-acetylcysteine as a means to reduce nicotine withdrawal
39. Withdrawal regulation training
40. Withdrawal and hippocampal nAChR
41. Neurobiological aspect of alcohol and nicotine and in terms of withdrawal
42. Nicotine withdrawal and psychosocial stresses
43. Tobacco withdrawal and responses of different groups and populations
44. Craving and withdrawal Symptoms in pregnancy
45. Measures of nicotine craving and applications

Part 6: Nicotine as a Component of Dual-use and Poly Addictions
46. Nicotine and alcohol
47. Relationship between cannabis and tobacco cigarette use
48. Nicotine exposure and cocaine reward
49. Nicotine and methamphetamine
50. Personality profiles in marijuana and nicotine users
51. Risk profiles of poly tobacco

Part 7: Cellular Effects and Molecular Biology of Nicotine
52. Smoking within the context of genome-wide analysis
53. Transcription and L-type calcium channels by nicotine
54. The alpha3beta4alpha5 nicotinic receptor
55. The TRPM4-SLC6A16 gene and nicotine addiction
56. The cell membrane and nicotinic acetylcholine receptor subtypes
57. Brain gene expression in the context of nicotine rewards
58. Neurotensin and nicotine

Part 8: Screening and Markers
59. LC-MS/MS method for simultaneous determination of nicotine and its metabolite cotinine (a metabolite of nicotine)
60. Urinary cotinine measures and applications to the community
61. The young and smoke exposure assessed by urinary cotinine (a metabolite of nicotine)
62. The 3'-hydroxycotinine to cotinine ratio and applications
63. The Wisconsin Inventory of Smoking Dependence Motives (WISDM)) and applications

Part 9: Treatments and Strategies for Nicotine Addiction and Related Features
64. Reduction of nicotine in tobacco and impact
65. Tobacco cessation clinical practices and receptivity
66. Nicotine addiction via smokeless tobacco and cessation
67. Use of nicotine patches in smokers
68. Pharmacist-managed tobacco cessation clinic
69. Varenicline for smoking cessation
70. Smoking Cessation Counseling
71. Perceptions about nicotine in the context of replacement therapies
72. Relapse to smoking in quitters
73. Social support and smoking quitters
74. Smoking cessation and smoking cessation counseling

Part 10: Policy Aspects
75. International aspects of treating tobacco dependence
76. The policy of European tobacco control
77. E-cigarettes and policy
78. Rolling of tobacco and policy
79. Smoke-free policies
80. Graphic cigarette warning labels
81. Cigarette packaging


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

About the Editor

Victor Preedy

Victor R. Preedy, PhD, is Professor of Nutritional Biochemistry in the Department of Nutrition and Dietetics, at the King's College in London. He is also a Professor of Clinical Biochemistry in the Department of Clinical Biochemistry. Dr. Preedy is also Director of the Genomics Centre, King's College London. He was elected a Fellow of the Royal College of Pathologists in 2000. In 1993, he gained a D.Sc. degree for his outstanding contribution to protein metabolism. He was elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Dr. Preedy was also elected as a Fellow of the Royal Society for Public Health (RSPH). He has written or edited over 550 articles, which includes over 160 peer-reviewed manuscripts based on original research and 85 reviews and 30 books. His interests pertain to matters concerning Public Health and how this is influenced by nutrition, addictions and other lifestyle factors. Professor Preedy is especially committed to bridging the person-public health divide.

Affiliations and Expertise

Professor of Nutritional Biochemistry in the Department of Nutrition and Dietetics Professor of Clinical Biochemistry in the Department of Clinical Biochemistry Director of the Genomics Centre King’s College, London

Ratings and Reviews