Neuroscience of Alcohol

Neuroscience of Alcohol

Mechanisms and Treatment

1st Edition - March 19, 2019

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  • Editor: Victor Preedy
  • Paperback ISBN: 9780128131251
  • eBook ISBN: 9780128131268

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Description

Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance.

Key Features

  • Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function
  • Discusses alcohol use as a component of dual-use and poly addictions
  • Outlines numerous screening and treatment strategies for alcohol misuse
  • Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

Readership

Advanced students and researchers in the areas of neuroscience, drug abuse, addiction, and pharmacology

Table of Contents

  • PART I: INTRODUCTORY CHAPTERS
    1. Becoming a "Successful" Drinker and a Graduate: A Sociological Perspective on Alcohol Consumption by University Students
    CLAIRE TANNER, JO LINDSAY, ROSE LEONTINI, SIAN SUPSKI, JULIE HEPWORTH, TONI SCHOFIELD AND JOHN GERMOV
    2. Molecular Genetics Meets Sociology: Birth Cohort Effects on Alcohol Use and Relationship With Candidate Genes
    JAANUS HARRO AND MARILIIS VAHT
    3. Alcohol and Women: Unique Risks, Effects, and Implications for Clinical Practice
    LINDA RICHTER
    4. ADH and ALDH Polymorphisms in Alcoholism and Alcohol Misuse/Dependence
    MEERA VASWANI
    5. Acetaldehyde in the Brain After Ethanol Exposure: Research Progress and Challenges
    MOSTOFA JAMAL, ASUKA ITO, NAOKO TANAKA, AYAKA TAKAKURA, KIYOSHI AMENO AND HIROSHI KINOSHITA
    6. Consequences of Ethanol Exposure on Neurodevelopment
    MANUEL ALVES DOS SANTOS JÚNIOR, GERMANA SILVA VASCONCELOS, CAREN NÁDIA SOARES DE SOUSA, DANIELLE MACEDO AND SILVÂNIA MARIA MENDES VASCONCELOS
    7. Animal Models of Binge Drinking: Behavior and Clinical Relevance
    JÉRÔME JEANBLANC, BENJAMIN ROLLAND, PIERRE MAURAGE, FABIEN GIERSKI AND MICKAEL NAASSILA

    PART II: NEUROBIOLOGY
    8. Prenatal Alcohol Exposure: Developmental Abnormalities in the Brain
    DAVID J. ROHAC, CHARLES W. ABBOTT AND KELLY J. HUFFMAN
    9. Connecting Prenatal Alcohol, Its Metabolite Acetaldehyde, and the Fetal Brain
    M. GABRIELA CHOTRO, MIRARI GAZTAÑAGA AND ASIER ANGULO-ALCALDE
    10. Fetal Alcohol Exposure and the Central Nervous Control of Breathing
    O. PIERREFICHE
    11. Synaptic Plasticity in the Hippocampus and Alcohol Exposure During Brain Development
    O. PIERREFICHE
    12. Ethanol and Cortical Spreading Depression: The Protective Role of α-Tocopherol
    RUBEM CARLOS ARAÚJO GUEDES, RANILSON DE SOUZA BEZERRA AND RICARDO ABADIE-GUEDES
    13. Brain Electrophysiological Signatures in Human Alcoholism and Risk
    CHELLA KAMARAJAN
    14. Alcohol and Hippocampal Epileptiform Activity
    VICTOR DIEGO CUPERTINO COSTA, LUIZ EDUARDO CANTON SANTOS, ANTÔNIO MÁRCIO RODRIGUES, FÚLVIO ALEXANDRE SCORZA, CARLA ALESSANDRA SCORZA, ARTHUR GUERRA DE ANDRADE AND ANTÔNIO-CARLOS GUIMARÃES DE ALMEIDA
    15. Effects of Alcohol on the Corpus Callosum
    EMILIO GONZÁLEZ-REIMERS, CANDELARIA MARTÍN-GONZÁLEZ, LUCÍA ROMERO-ACEVEDO, GERALDINE QUINTERO-PLATT, EMILIO GONZALEZ-ARNAY AND FRANCISCO SANTOLARIA-FERNÁNDEZ
    16. The Role of the Lateral Habenula Circuitries in Alcohol Use Disorders
    NIMISHA SHIWALKAR, WANHONG ZUO, ALEX BEKKER AND JIANG-HONG YE
    17. Ventral Pallidum and Alcohol Addiction
    ASHEETA A. PRASAD AND GAVAN P. MCNALLY
    18. The Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion Channels in the Rewarding Effects of Ethanol
    MARIO RIVERA-MEZA
    19. Neuroimmune Aspects of Alcoholism and Affective Comorbidity
    SUDAN P. NEUPANE
    20. Social Drinking and Motor Inhibition: Evidences From FMRI Go/Nogo Tasks fMRI Studies on Alcohol Effect on Inhibition
    ELISA SCHRÖDER AND SALVATORE CAMPANELLA
    21. Myelopathy and Neuropathy Associated With Alcoholism
    HARUKI KOIKE
    22. Alcohol Consumption and the Risk of Amyotrophic Lateral Sclerosis
    FABRIZIO D’OVIDIO, UMBERTO MANERA AND ADRIANO CHIÒ
    23. Alcohol and Pain Interactions
    HENRY L. BLANTON, SUSAN E. BERGESON, DANIEL J. MORGAN AND JOSÉE GUINDON
    24. Neurobiological Aspects of Ethanol-Derived Salsolinol
    ELIO ACQUAS, SIMONA SCHEGGI AND ALESSANDRA T. PEANA
    25. Brain Networks in Active Alcoholism and Enduring Recovery: Functional Magnetic Resonance Imaging, Electrophysiological Studies, and Implications for Targeted Treatments
    GEORGE FEIN AND VALERIE CARDENAS
    26. Central Role of Amygdala and Hypothalamus Neural Circuits in Alcohol Withdrawal Symptom
    KATHERYN WININGER, VICTOR KARPYAK, SEUNGWOO KANG AND DOO-SUP CHOI 

    PART III: PSYCHOLOGY, BEHAVIOR, AND ADDICTION
    27. Neural Reward Processing in Human Alcoholism and Risk: A Focus on Event-Related Potentials, Oscillations, and Neuroimaging
    CHELLA KAMARAJAN
    28. Occipito-Temporal Sensitivity and Emotional Faces in Alcohol Use Disorder
    SARANYA SUNDARAM, EVA M. MÜLLER-OEHRING AND TILMAN SCHULTE
    29. Alcohol and Violence in Psychopathy and Antisocial Personality Disorder: Neural Mechanisms
    NATHAN J. KOLLA AND CHRISTINE C. WANG
    30. Language Lateralization in Fetal Alcohol Spectrum Disorders
    ANNUKKA K. LINDELL
    31. Deprivation in Rewards and Alcohol Misuse
    ASHLEY A. DENNHARDT, SAMUEL F. ACUFF, ALI M. YURASEK AND JAMES G. MURPHY
    32. Alcohol (Mis)Use in Individuals With Mild to Borderline Intellectual Disability
    NEOMI VAN DUIJVENBODE, JOANNE E.L. VANDERNAGEL AND ROBERT DIDDEN
    33. Sex, Stress, and Neuropeptides Interact to Influence Alcohol Consumption
    TODD B. NENTWIG AND JUDITH E. GRISEL
    34. Maternal Separation Stress in Fetal Alcohol Spectrum Disorders: A Case of Double Whammy
    SHIVA M. SINGH AND BONNIE ALBERRY
    35. Impulsivity and Binge Drinking: A Neurocognitive Perspective
    PIERRE MAURAGE, SÉVERINE LANNOY, MICKAEL NAASSILA, BENJAMIN ROLLAND AND JOËL BILLIEUX
    36. Acetaldehyde and Motivation
    ANNA BRANCATO AND CARLA CANNIZZARO
    37. Age-Related Differences in the Appetitive and Aversive Motivational Effects of Alcohol
    RICARDO MARCOS PAUTASSI
    38. Alcoholism in Bipolar Disorders: An Overview of Epidemiology, Common Pathogenetic Pathways, Course of Disease, and Implications for Treatment
    MARCO DI NICOLA, LORENZO MOCCIA, VITTORIA RACHELE FERRI, ISABELLA PANACCIONE AND LUIGI JANIRI
    39. Socio-Emotional Deficits in Severe Alcohol Use Disorders
    PIERRE MAURAGE, BENJAMIN ROLLAND AND FABIEN D’HONDT
    40. Relapse Risks in Patients With Alcohol Use Disorders
    AYAKO YAMASHITA AND SHIN-ICHI YOSHIOKA
    41. The Neurocognitive Effects of Alcohol Hangover: Patterns of Impairment/Nonimpairment Within the Neurocognitive Domains of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition
    L. DARREN KRUISSELBRINK

    PART IV: PHARMACOLOGY, NEUROACTIVES, MOLECULAR, AND CELLULAR BIOLOGY
    42. Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk
    PATRIZIA PORCU, ALESSANDRA CONCAS AND A. LESLIE MORROW
    43. Alcohol’s Effects on Extracellular Striatal Dopamine
    ASHLEY A. VENA AND RUEBEN GONZALES
    44. Nicotinic Cholinergic Mechanisms in Alcohol Abuse and Dependence
    SHAFIQUR RAHMAN AND RICHARD L. BELL
    45. Opioid System and Alcohol Consumption
    JORGE JUÁREZ AND LUZ M. MOLINA-MARTÍNEZ
    46. The Enkephalinergic System and Ethanol Effects
    MILAGROS MÉNDEZ, KARLA HERNÁNDEZ-FONSECA AND PAULA ABATE
    47. Alcohol and Central Glutamate Activity: What Goes Up Must Come Down?
    RICHARD L. BELL, YOUSSEF SARI AND SHAFIQUR RAHMAN
    48. Ethanol and Hippocampal Gene Expression: Linking in Ethanol Metabolism, Neurodegeneration, and Resistance to Oxidative Stress
    MARIO DÍAZ, VERÓNICA CASAÑAS-SÁNCHEZ, DAVID QUINTO- ALEMANY AND JOSÉ A. PÉREZ
    49. Stress, Alcohol, and Hippocampal Genes
    JESSICA A. BAKER, LU LU AND KRISTIN M. HAMRE
    50. Genes and Alcoholism: Taste, Addiction, and Metabolism
    ARTURO PANDURO, INGRID RIVERA-IÑIGUEZ, OMAR RAMOS-LOPEZ AND SONIA ROMAN
    51. Ethanol Exposure During Development, and Brain Oxidative Stress
    JOANA GIL-MOHAPEL, CLAUDIA D. BIANCO, PATRICIA A. CESCONETTO, ARIANE ZAMONER AND PATRICIA S. BROCARDO
    52. Alcohol-Induced Oxidative Stress in the Brain: Suggested Mechanisms, Associated Disorders, and Therapeutic Strategies
    MIROSLAVA GEORGIEVA VARADINOVA, MARIA LOZANOVA VALCHEVA-TRAYKOVA AND NADKA IVANOVA BOYADJIEVA
    53. Lead Exposure and Ethanol Intake: Oxidative Stress as a Converging Mechanism of Action
    MIRIAM B. VIRGOLINI, MARA S. MATTALLONI, ROMINA DEZA-PONZIO, PAULA A. ALBRECHT AND LILIANA M. CANCELA

    PART V: ALCOHOL AND OTHER ADDICTIONS
    54. Alcohol and Gambling Addiction
    MARKO MARTINAC, DALIBOR KARLOVIć AND DRAGAN BABIć
    55. Neuroscience of Alcohol and Crack Cocaine Use: Metabolism, Effects and Symptomatology
    ANTONIO GOMES DE CASTRO-NETO, ROSSANA CARLA RAMEH-DE-ALBUQUERQUE, POLLYANNA FAUSTA PIMENTEL DE MEDEIROS AND ROBERTA UCHÔA
    56. The Impact of Ethanol Plus Caffeine Exposure on Cognitive, Emotional, and Motivational Effects Related to Social Functioning
    MERCÈ CORREA, LAURA LÓPEZ-CRUZ, SIMONA PORRU AND JOHN D. SALAMONE

    PART VI: BIOMARKERS AND SCREENING
    57. Biomarkers of Alcohol Misuse
    AURELIE DE VOS, RANI DE TROYER AND CHRISTOPHE STOVE
    58. Phosphatidylethanol Homologs in Blood as Biomarkers for the Time Frame and Amount of Recent Alcohol Consumption
    NATHALIE HILL-KAPTURCZAK, DONALD M. DOUGHERTY, JOHN D. ROACHE, TARA E. KARNS-WRIGHT, MARISA LOPEZ-CRUZAN AND MARTIN A. JAVORS
    59. Metabolomics to Differentiate Alcohol Use Disorders From Social Drinkers and Alcohol-Naive Subjects
    BAHARUDIN BRAHIM AND KESHAMALINI GOPALSAMY
    60. Meconium Biomarkers of Prenatal Alcohol Exposure
    ESTHER PAPASEIT, ROBERT MUGA, PAOLA ZULUAGA, ARANTZA SANVISENS AND MAGÍ FARRÉ
    61. Applications of the Alcohol Use Disorders Identification Test (AUDIT) in Distinct Health Areas
    MARÍA-TERESA CORTÉS-TOMÁS AND JOSÉ-ANTONIO GIMÉNEZ-COSTA
    62. Craving Measurement and Application of the Alcohol Craving Experience Questionnaire
    JASON M. COATES, GERALD F.X. FEENEY, MATTHEW J. GULLO, DAVID J. KAVANAGH, ROSS MCD. YOUNG, JON MAY, JACKIE ANDRADE AND JASON P. CONNOR

    PART VII: TREATMENTS, STRATEGIES AND RESOURCES
    63. Negative Emotions and Alcohol Use Disorder Treatment
    MATT G. KUSHNER AND JUSTIN J. ANKER
    64. Use of Baclofen in Alcohol Use Disorder: A Clinical Approach
    BRUCE IMBERT
    65. Baclofen-Induced Neurotoxicity
    MAGALI CHARTIER, LUCIE CHEVILLARD AND BRUNO MÉGARBANE
    66. Treatment With Nalmefene in Alcoholism
    PHILIPPE LARAMÉE
    67. Dual Therapy for Alcohol Use Disorders: Combining Naltrexone With Other Medications
    JANICE FROEHLICH, EMILY NICHOLSON AND JULIAN DILLEY
    68. The Avermectin Family as Potential Therapeutic Compounds for Alcohol Use Disorder: Implications for Using P2X4 Receptor as a Drug-Screening Platform
    NHAT HUYNH, SHERAZ KHOJA, LIANA ASATRYAN, MICHAEL W. JAKOWEC AND DARYL L. DAVIES
    69. Alcohol Withdrawal Syndrome: Clinical Picture and Therapeutic Options
    SARAH JESSE AND ALBERT LUDOLPH
    70. Resources for the Neuroscience of Alcohol
    RAJKUMAR RAJENDRAM AND VICTOR R. PREEDY

Product details

  • No. of pages: 736
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: March 19, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128131251
  • eBook ISBN: 9780128131268

About the Editor

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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  • Odilon T. Thu Mar 28 2019

    M. Sc., B. Appl. Sc, T.P., Fin. Pl., A.V.A.,

    Impressive research work! Very detailed facts, consequences, remedies, ...