Neuronal Information Transfer

Neuronal Information Transfer

1st Edition - January 1, 1978

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  • Editor: Arthur Karlin
  • eBook ISBN: 9780323148825

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Description

Neuronal Information Transfer contains the proceedings of the symposium on Neuronal Information Transfer, held in Columbia University in June 1977. The symposium focuses on the molecular, ultrastructural, and morphological study of a number of systems showing defined receptor-effector interactions. The collection of papers presented in the symposium provides insights into the understanding of nervous information transfer. The book includes findings and studies on the biogenic amine systems, cholinergic system, amino acid systems, and brain peptides and opiate system. Treatises that covered cyclic nucleotides and the neuronal structure and development are also presented. Neuroscientists, neurologists, researchers, educators, and students in neuroscience will benefit from this book.

Table of Contents


  • List of Participants

    Preface

    Opening Address

    Text

    References

    Part I Biogenic Amine Systems

    Genetic, Structural, and Molecular Mechanisms Governing the Long-Term Regulation of Tyrosine Hydroxylase, a Neurotransmitter Synthesizing Enzyme in the Brain

    Neurotransmitter Synthesizing Enzymes in the Brain

    Long-Term Regulation of Brain Tyrosine Hydroxylase

    Summary

    References

    Regulations of Activity of the Nigrostriatal Dopaminergic Systems

    Introduction

    Influences of Substance P and GABAergic Neurons on the Activity of the Nigrostriatal Dopaminergic Pathway

    Imbalance between the Activity of the Two Nigrostriatal Dopaminergic Pathways

    The Release of Dopamine from Dopaminergic Dendrites

    Role of the Dendritic Release of Dopamine in the Control of the Activity of the Nigrostriatal Dopaminergic Neurons

    Concluding Remarks

    References

    Regulation of Sensitivity to ß-Adrenergic Stimulation in the Rat Pineal

    Introduction

    Variation in Sensitivity of Induction

    Receptors and Adenylate Cyclase

    Cyclic AMP and Phosphodiesterase

    Protein Kinase

    References

    Molecular Properties and Regulation of Alpha- and Beta-Adrenergic Receptors

    Introduction

    Identification of α- and ß-Adrenergic Receptors by Radioligand Binding

    Desensitization of Adrenergic Receptors

    Receptor Supersensitivity

    Summary and Conclusions

    References

    Biochemical Characterization of Neurotransmitter Receptors in the Brain

    Introduction

    Methodological Principles

    The Dopamine Receptor

    Evidence for a Two-State Model of Neurotransmitter Receptors

    References

    Part II Cholinergic System

    The Cholinergic Electromotor System of Torpedo: Recent Biochemical and Morphological Findings

    Introduction

    Developmental Studies

    Tissue Fractionation

    Studies of Synaptic Vesicle Dynamics

    Conclusions

    References

    Studies on the Mechanism of Acetylcholine Release in Mammalian Tissues

    Introduction

    Amount of ACh in a Vesicle and in a Quantum

    Specificity of ACh Release and Storage

    Turnover of ACh in Nerve Terminal Pools

    Tissue Differences in ACh Storage and Release or Their Control

    References

    Nerve Excitability: From Descriptive Phenomenology to Molecular Interpretation

    Introduction: Early Theories of Axonal Conduction and Synaptic Transmission

    Alternative Interpretation of the Function of ACh in Excitable Membranes as a Result of Biochemical and Physiochemical Analyses

    A Model Integrating Biochemical, Biophysical, and Thermodynamic Data

    The Role of ACh at Synaptic Junctions

    References

    Acetylcholine Receptor-Mediated Ion Flux in Electroplax Membrane Microsacs

    Text

    References

    Acetylcholine Receptor: Accelerated Dissociation of Receptor-Ligand Complexes

    Introduction

    Methods

    Results

    Discussion

    References

    Elementary Chemical Reactions of Acetylcholine with Receptor and Esterase: Relationship to Neuronal Information Transfer

    Introduction

    Localization of Acetylcholine Receptor and Acetylcholinesterase

    Do Receptor and Esterase Compete for Acetylcholine?

    Kinetic Analyses

    Acetylcholinesterase

    Acetylcholine Receptor

    Comparisons between Competitive and Sequential Reactions of Acetylcho-line at the Synapse

    References

    Part III Amino Acid Systems

    Roles of GABA in Neurons in Information Processing in the Vertebrate CNS

    Introduction

    Disinhibition as a Major Organizing Principle

    GABA Neurons and Problems of Functional Coordination in the Nervous System

    Identifying GABA-Releasing Neurons in Regions of the Vertebrate CNS

    Cerebellum

    Spinal Cord

    Olfactory Bulb

    Basal Ganglia

    Interactions among Neurotransmitter Systems

    "Wet" Neurobiology and Cybernetics

    References

    An Evaluation of the Proposed Transmitter Role of Glutamate and Taurine

    Introduction

    Excitatory Amino Acids

    Taurine

    Conclusion

    References

    Part IV Brain Peptides and Opiate System

    Biologically Active Peptides in the Brain

    Introduction

    Biologically Active Peptides

    Mapping Biologically Active Peptides in the Brain

    Biosynthesis and Degradation of Peptides

    Concluding Remarks

    References

    Opioid Peptides

    Introduction

    Pharmacological Activity of Opioid Peptides

    Multiple Opiate Receptors

    Enkephalins as Neurotransmitters

    Biogenesis of Enkephalins

    Concluding Remarks

    References

    On the Physiologic Role of Endorphins

    Introduction

    Endorphin Pharmacology

    Functional Effects of Naloxone

    Endorphin Steady-State Levels and Turnover

    Induced Changes in Pituitary Endorphin Levels

    References

    Discovery and Function of the Endorphins

    Introduction

    Endorphins and Morphine—Chemical Comparisons

    Multiple Endorphin Systems

    Receptors for Opioid Alkaloids and for Opioid Peptides

    Endorphins and Opiates—Actions Other than Analgesia

    Summary

    References

    Recent Studies on Opiate Receptors and Analogs of Enkephalin

    Introduction

    Effects of N-Terminus and C-Terminus Alterations of Enkephalin

    Evidence for Location of Opiate Receptors in Organotypic Cultures

    References

    Part V Cyclic Nucleotides

    Regulation of Cyclic AMP Metabolism by Neural Hormones in Brain

    Introduction

    Role of Cyclic AMP in the Nervous System

    Regulation of Neural Cyclic AMP Metabolism

    Concluding Remarks

    References

    Electrophysiological Assessment of Mononucleotides and Nucleosides as First and Second Messengers in the Nervous System

    Introduction

    First Messenger Criteria

    Second Messenger Criteria

    Central Norepinephrine as a First Messenger for Cyclic AMP Second Messages

    Dopamine as a First Messenger for Cyclic AMP

    Cyclic GMP as a Second Messenger in the CNS

    Central Purines as First Messengers for Cyclic AMP Second Messages

    Mononucleotide Effects in Cultured Sympathetic Ganglia

    Conclusions and Speculations

    References

    Part VI Neuronal Structure and Development

    Development of Peripheral Monoaminergic Neurons

    Introduction

    Development of Adrenergic Ganglia and the Adrenal Medulla

    3H-Thymidine Incorporation by Developing Adrenergic Ganglion Cells

    Development of the Monoaminergic Innervation of the Gut

    Conclusions

    References

    Characterization, Distribution, and Appearance of Surface Carbohydrates on Growing Neurites

    Introduction

    Topographic Distribution of Surface Carbohydrates on Growing Neurons

    Appearance and Movement of Plasmalemmal Lectin Receptors during Membrane Growth

    Surface Carbohydrate Composition of Growth Cones from Different Neuron Types

    Summary and Conclusions

    References

    Selective Synapse Suppression as a Mechanism Contributing to Specificity of Connections in the Nervous System

    Text

    References

    The Functional Motor Innervation of Supernumerary Hind Limbs in the Chick Embryo

    Introduction

    Results

    Discussion

    References

    Cerebellar Maturation after Perinatal Alterations in Connectivity—Evidence for Intrinsic Determinism

    Introduction

    Methods

    Results

    Discussion

    References

    Index

Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323148825

About the Editor

Arthur Karlin

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