1st Edition

Editor-in-Chiefs: Elliot Krames P. Hunter Peckham Ali Rezai
Hardcover ISBN: 9780123742483
eBook ISBN: 9780080921396
Imprint: Academic Press
Published Date: 26th June 2009
Page Count: 1088
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Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs.
The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices.
All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.

Key Features

Key Features

  • The first comprehensive reference on the emerging field of Neuromodulation
  • Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society
  • Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise
  • Over 1200 pages in splendid full color, richly illustrated
  • Important areas of application include:
    control of chronic pain
    delivery of drugs to the nervous system via implanted devices
    control of epilepsy, Parkinson, etc.
    functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events
    stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs)
    overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces


Basic scientists and academic clinicians in neuroscience, particularly neurophysiology, behavioral neuroscience, sensory neuroscience (including audiology, ophthalmology, and particularly pain), neuroanatomy, neurosurgery, neurological diseases, as well as physiologists in Cardiology, Gastroenterology, Urology. Biomedical engineers Clinical specialists: anesthesiology, neurosurgery, neurology, neurophysiology, cardiology, gastroenterology, urology and orthopedics

Table of Contents

Prolog (Joseph Pancrazio)

SECTION I AN INTRODUCTION TO NEUROMODULATION Introduction Elliot S. Krames 1 What Is Neuromodulation? Elliot S. Krames, Ali R. Rezai, P. Hunter Peckham, and Farag Aboelsaad 2 Neuromodulation: A Historical Perspective Philip L. Gildenberg 3 Neuromodulation Technologies: Whom Do We Serve? Allen R. Dyer and Mary Pat Aardrup 4 Challenges in Moving Toward Product Development Paul Meadows 5 The Birth of an Industry James Cavuoto 6 Beginnings of the Societies Ross Davis, Philip L. Gildenberg, Giancarlo Barolat, Elliot Krames, Dejan Popovic, and Paul Meadows 7 Clinical Study Design Daniel B. Carr and Anthony Eidelman 8 Psychological Issues and Evaluation for Patients Undergoing Implantable Technology Daniel M. Doleys 9 Deep Brain Stimulation: Ethical Issues in Clinical Practice and Neurosurgical Research Joseph J. Fins SECTION II FUNDAMENTALS OF NEUROMODULATION Introduction Narendra Bhadra, J. Thomas Mortimer, and Hunter Peckham 10 Anatomy of the Nervous System Joshua M. Rosenow 11 Fundamentals of Electrical Stimulation J. Thomas Mortimer and Narendra Bhadra 12 Neuromodulation and Neuronal Plasticity Alon Y. Mogilner 13 Gene-Based Neuromodulation Thais Federici, Jonathan Riley, and Nicholas Boulis SECTION IIA MECHANISMS Introduction 14 Principals of Electric Field Generation for Stimulation of the Central Nervous System Warren M. Grill 15 Mechanisms of Action of Deep Brain Stimulation: A Review Kendall Lee, Charles Blaha, and Jonathan M. Bledsoe<BR


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© Academic Press 2009
Academic Press
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About the Editor-in-Chief

Elliot Krames

Affiliations and Expertise

Pacific Pain Treatment Centers, San Francisco, CA, USA Medical Director, Anesthesiology, Pain Medicine

P. Hunter Peckham

Dr. Peckham is the Donnell Institute Professor of Biomedical Engineering and Orthopaedics at Case Western Reserve University and Director, Cleveland Functional Electrical Stimulation Center. The major area of Dr. Peckham's research is in rehabilitation engineering and neuroprostheses. He’s also the Founder for the Institute for Functional Restoration at the Case Western School of Medicine and the Co-Director of MetroHealth Rehabilitation Institute of Ohio. A holder of eight patents, he is a member of multiple councils, Dr. Peckham is also a fellow of the American Institute of Medical and Biological Engineering.

Affiliations and Expertise

Case Western Reserve University, Cleveland, OH, USA

Ali Rezai

Dr. Rezai is currently Associate Dean of Neuroscience and the Director of the Neurological Institute at OSU. Dr. Rezai has published over 150 peer reviewed articles, more than 30 book chapters, and serves on the editorial board of five journals. Dr. Rezai is currently the Past President of the Congress of Neurological Surgeons (CNS), the largest neurosurgical societies in the world, as well as the Past President North American Neuromodulation Society (NANS), and the American Society of Stereotactic and Functional Neurosurgery (ASSFN).Dr. Rezai’s research focuses on mechanisms of neurostimulation, and developing neuromodulation devices and novel therapeutic strategies for treatment of neurological disorders.

Affiliations and Expertise

The Ohio State University Wexner Medical Center, Columbus OH, USA


"This reference is the product of a varied and exceptionally diverse collection of multidisciplinary, leading experts in the field who have added their significant contributions to the field of neuromodulation." - Elmer "Al" Pinzone, M.D., M.P.H., in Practical Pain Management, October 1, 2009 

"Neuromodulation will be the go-to-it reference work for this rapidly expanding and fascinating field. The editors have assembled an all-star group of contributors who comprehensively cover all aspects of neuromodulation in the treatment of human disease and dysfunction." - John D. Loeser, M.D., Departments of Neurological Surgery and Anesthesiology, University of Washington, Seattle, USA

"The greater than 40 year history of scientific inquiry into the interface between neural tissue and therapeutic electrical fields or targeted drug infusion has resulted in a body of rapidly growing evidence for positive effects when these technologies are applied to selected patients who suffer from chronic neurological diseases. The editors of Neuromodulation have organized a definitive knowledge resource for this growing and complex field by assembling many of the world leaders in basic neuroscience, electrical engineering and drug infusion technologies, and clinical investigation. Any new paradigm in medicine, such as neuromodulation, deserves such an outstanding text to help the clinician and researcher to navigate through novel concepts, clinical outcomes and promising new applications." -Richard E. Kuntz, M.D., M.Sc., Sr. Vice President and President, Medtronic Neuromodulation, Minneapolis, USA

"As it has become possible to directly interact with neural tissue, neuromodulation as a new and very promising field of therapeutic approaches has emerged on a very steep path of development. Since the first applications to the treatment of pain with electrical stimulation numerous newly developed methods, including direct electrical st