1st Edition - May 5, 2009

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  • Editors-in-Chief: Elliot Krames, P. Hunter Peckham, Ali Rezai
  • eBook ISBN: 9780080921396

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Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices. All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.

Key Features

Key Features

  • The first comprehensive reference on the emerging field of Neuromodulation
  • Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society
  • Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise
  • Over 1200 pages in splendid full color, richly illustrated
  • Important areas of application include:
    control of chronic pain
    delivery of drugs to the nervous system via implanted devices
    control of epilepsy, Parkinson, etc.
    functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events
    stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs)
    overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces


Basic scientists and academic clinicians in neuroscience, particularly neurophysiology, behavioral neuroscience, sensory neuroscience (including audiology, ophthalmology, and particularly pain), neuroanatomy, neurosurgery, neurological diseases, as well as physiologists in Cardiology, Gastroenterology, Urology.
Biomedical engineers
Clinical specialists: anesthesiology, neurosurgery, neurology, neurophysiology, cardiology, gastroenterology, urology and orthopedics

Table of Contents

  • Prolog (Joseph Pancrazio)

    Elliot S. Krames
    1 What Is Neuromodulation?
    Elliot S. Krames, Ali R. Rezai, P. Hunter Peckham, and Farag Aboelsaad
    2 Neuromodulation: A Historical Perspective
    Philip L. Gildenberg
    3 Neuromodulation Technologies: Whom Do We Serve?
    Allen R. Dyer and Mary Pat Aardrup
    4 Challenges in Moving Toward Product Development
    Paul Meadows
    5 The Birth of an Industry
    James Cavuoto
    6 Beginnings of the Societies
    Ross Davis, Philip L. Gildenberg, Giancarlo Barolat, Elliot Krames, Dejan Popovic, and Paul Meadows
    7 Clinical Study Design
    Daniel B. Carr and Anthony Eidelman
    8 Psychological Issues and Evaluation for Patients Undergoing Implantable Technology
    Daniel M. Doleys
    9 Deep Brain Stimulation: Ethical Issues in Clinical Practice and Neurosurgical Research
    Joseph J. Fins
    Narendra Bhadra, J. Thomas Mortimer, and Hunter Peckham
    10 Anatomy of the Nervous System
    Joshua M. Rosenow
    11 Fundamentals of Electrical Stimulation
    J. Thomas Mortimer and Narendra Bhadra
    12 Neuromodulation and Neuronal Plasticity
    Alon Y. Mogilner
    13 Gene-Based Neuromodulation
    Thais Federici, Jonathan Riley, and Nicholas Boulis
    14 Principals of Electric Field Generation for Stimulation of the Central Nervous System
    Warren M. Grill
    15 Mechanisms of Action of Deep Brain Stimulation: A Review
    Kendall Lee, Charles Blaha, and Jonathan M. Bledsoe
    16 Computational Modeling of Deep Brain Stimulation
    Cameron C. McIntyre
    Joseph Pancrazio and Hunter Peckham
    17 Electrodes for the Neural Interface
    Dustin J. Tyler and Katharine H. Polasek
    18 Implantable Neural Stimulators
    P. Hunter Peckham and D. Michael Ackermann, Jr
    19 Designing a Neural Interface System to Restore Mobility
    John P. Donoghue and Leigh Hochberg
    20 MRI Safety and Neuromodulation Systems
    Frank G. Shellock
    Elliot S. Krames and Andre Machado
    21 Physiology and Pathophysiology of Chronic Pain
    Joshua M. Rosenow
    22 The Endogenous Neuromodulation System
    Allan I. Basbaum, Joao Braz, Michael H. Ossipov and Frank Porreca
    23 Management Strategies for Chronic Pain
    Rollin M. Gallagher
    Section IVA Intrathecal Therapies
    24 Transcutaneous Electrical Nerve Stimulation (TENS): A Review
    Kathleen Sluka, Howard S. Smith and Deirdre M. Walsh
    25 Mechanisms of Spinal Cord Stimulation in Neuropathic and Ischemic Pain Syndromes
    Bengt Linderoth, Robert D. Foreman, Björn A. Meyerson
    26 The Cost-Effectiveness of Spinal Cord Stimulation
    Richard B. North, Jane Shipley and Rod S. Taylor
    27 SCS for Painful Neuropathies
    Giancarlo Barolat
    28 Neurostimulation in the Treatment of Complex Regional Pain Syndrome
    Joshua P. Prager
    29 Peripheral nerve stimulation (PNS) for Pain Peripheral Neuralgia and CRPS
    Michael Stanton-Hicks
    30 Occipital Neurostimulation (ONS) for Treatment of Intractable Headache Syndromes
    Richard L. Weiner and Kenneth M. Alo`
    31 Subcutaneous Targeted Stimulation
    Teodor Goroszeniuk and Sandesha Kothari
    Section IVB Neuromodulation for Pain
    32 Relevant Anatomy for Spinal Delivery
    Timothy R Deer, Matthew Ranson and Douglas Stewart
    33 The Rational Use of Intrathecal Opioid Analgesics
    Elliot S. Krames and Mouchir Harb
    34 Intrathecal Analgesics, Choice of System
    Marshall D. Bedder
    35 Intrathecal Non-Opioid Analgesics for the Control of Pain
    Enrique Reig, David Abejón, and Elliot S. Krames
    36 Compounding Intrathecal Drugs
    Richard L. Rauck
    37 Intracerebroventricular Opioid Administration for Chronic Pain
    Katherine E. Groothuis and Robert M. Levy

    Section IVC Intracranial Procedures for Chronic Pain
    38 Deep Brain Stimulation for Pain
    Erlick A.C. Pereira, Sarah L.F. Owen, Alexander L. Green and Tipu Z. Aziz
    39 Deep-Brain Stimulation of the Posterior Hypothalamus in Chronic Cluster Headache
    A. Franzini, G. Messina, M. Leone, G. Bussone, C. Marras, G. Tringali and G. Broggi
    40 Motor Cortex Stimulation for the Treatment of Neuropathic Pain
    J.P. Nguyen, J.P. Lefaucheur, S. Raoul, V. Roualdes, Y. Péréon, and Y. Keravel
    SECTION V - Movement Disorders
    41 Movement Disorders: Anatomy and Physiology Relevant to Deep Brain Stimulation
    Brian Harris Kopell, Gregory F. Molnar and Bradley Hiner
    42 Deep Brain Stimulation in Parkinson’s Disease
    Karl Sillay and Philip Starr
    43 Deep Brain Stimulation for Tremor
    Adam P. Burdick, Michael S. Okun and Kelly D. Foote
    44 Infusion Therapy for Movement Disorders
    Joseph C. Hsieh and Richard D. Penn
    45 Deep Brain Stimulation for Torsion Dystonia
    Ron L. Alterman and Michele Tagliati
    46 Deep Brain Stimulation in Tourette Syndrome
    Veerle Visser-Vandewalle, Yasin Temel and Linda Ackermans
    47 Surgical Management of Hemifacial Spasm and Meige Syndrome
    Hyun Ho Jung and Jin Woo Chang
    48 Deep Brain Stimulation (DBS) of the Medial Thalamus for Movement Disorders: The role of the Centromedianum - Parafascicular complex
    Paolo Mazzone, E Scarnati and G Della Marca
    Ash Sharan and Ali Rezai
    49 Epilepsy: Anatomy, Physiology, Pathophysiology and Disorders
    David King-Stephens
    50 Vagus Nerve Stimulation
    Arun Paul Amar, Michael L. Levy, Charles Y. Liu and Michael L.J. Apuzzo
    51 Deep Brain Stimulation for Epilepsy
    Casey H. Halpern, Uzma Samadani, Brian Litt, Jurg L. Jaggi and Gordon H. Baltuch
    52 Cerebellar Stimulation for Epilepsy
    Steven Falowksi, Ashwini D. Sharan, Amanda Celii and Ross Davis
    53 Closed Loop Stimulation in the Control of Focal Epilepsy
    J. Smith, K. Fountas, M. Murro, Y. Park, P. Jenkins, D. Greene and R. Esteller
    SECTION VII Neuromodulation in Psychiatry
    Benjamin D. Greenberg
    54 Electroconvulsive Therapy, Transcranial Magnetic Stimulation, and Vagus Nerve Stimulation for Depression
    Linda L Carpenter,, Margaret C. Wyche, Gerhard M. Friehs and John O’Reardon
    55 Electrical brain stimulation in treatment-resistant obsessive-compulsive disorder: parcellation, and cyto- and chemoarchitecture of the bed nucleus of the stria terminalis, a review
    Kris van Kuyck, Loes Gabriëls, and Bart Nuttin
    56 Deep brain stimulation for highly refractory depression
    Benjamin D. Greenberg
    57 Surgical Treatment for Refractory Drug Addictions
    Bomin Sun, Shikun Zhan, Dianyou Li, and Hemmings Wu
    P. Hunter Peckham
    58 Stimulation for the Return of Hearing
    Blake S. Wilson and Michael F. Dorman
    59 The Development of Visual Prosthetic Devices to Restore Vision to the Blind
    Muhammad Memon and Joseph F. Rizzo III
    60 Stimulation for Return of Function after Stroke
    John Chae, Jayme Knutson and Lynne Sheffler
    61 Cortical Stimulation for the Treatment of Motor Deficits following Ischemic Stroke
    Janna Silverstein and Robert M. Levy
    62 Stimulation for Return of Upper and Lower Extremity Function
    Kevin L. Kilgore, Michael W. Keith and P. Hunter Peckham
    63 A Neural Prosthesis for Obstructive Sleep Apnea
    Dominique M. Durand
    Elliot S. Krames
    64 Neuronal Control of the Heart: Neuromodulation
    Jeffrey L. Ardell and Robert D. Foreman
    65 Disorders of Pacing
    Thomas Dresing
    66 Cardiac Pacemakers - Past, Present, and Future
    Guy Amit and Kara J. Quan
    67 Cardiac Defibrillators
    Thomas Dresing
    68 SCS for Peripheral Vascular Disorders
    Svante Horsch and Stefan Schulte
    69 Spinal Cord Stimulation for Refractory Angina
    Mike J.L. DeJongste and Robert D. Foreman
    70 Neuromodulation and Hypertension
    T.M. Mastracci and R.K. Greenberg
    71 Neuromodulation of Cardiac Dysfunction
    Sandra Machado, Kwangdeok Lee and Marc S. Penn
    72 Neural Control of the Colon
    Beverley Greenwood-Van Meerveld and Robert D. Foreman
    73 Spinal Cord Stimulation for Gastrointestinal Painful Disorders
    Leonardo Kapural
    74 Gastric Stimulation for Dysmotility Disorders and Obesity
    Cristian Sevcencu
    75 Intestinal Electrical Stimulation: Methodologies, Effects, Mechanisms,and Applications
    Jieyun Yin and Jiande D Z Chen
    76 Neurophysiology of the Genitourinary Organs
    William C. de Groat and Firouz Daneshgari
    77 Sacral Nerve Root Stimulation for Painful Bladder Syndrome/Interstitial Cystitis
    Adnan A. Al-Kaisy and K. Riaz Khan
    78 Neuromodulation for Voiding Dysfunction
    Sarah McAchran, Raymond Rackley and Sandip Vasavada
    Elliot S. Krames and Ali Rezai
    79 Deep Brain Stimulation for Obesity
    Michael Y. Oh
    80 Deep Brain Stimulation for Blood Pressure Control
    Erlick A.C. Pereira, Alexander L. Green and Tipu Z. Aziz
    81 Tinnitus
    Brian Harris Kopell and David Friedland
    82 Brain and Cerebrospinal Fluid Infusion Therapies for the Treatment of CNS Disease
    Daniel J. Abrams
    83 Deep Brain Stimulation for Cognitive Neuromodulation
    Nicholas D. Schiff
    84 Novel Neuromodulation Approaches for Alzheimer’s Disease and Other Neurodegenerative Conditions
    Julie G. Pilitsis and Roy A.E. Bakay
    Elliot S. Krames
    85 Deep Brain Stimulation: Surgical Technique
    Andre G Machado, Alon Y. Mogilner and Ali Rezai
    86 Spinal Cord Stimulation: Placement of Surgical Leads via Laminotomy - Techniques and Benefits
    Krishna Kumar, Goran Lind, Jaleh Winter, Shivani Gupta, Sharon Bishop and Bengt Linderoth
    87 Peripheral Nerve Stimulation
    Michael Stanton-Hicks
    88 Subcutaneous Peripheral Nerve Field Stimulation for Intractable Pain
    Giancarlo Barolat
    89 Surgical Placement of Occipital Leads
    Richard L. Weiner
    90 Surgical Technique: Intrathecal Medication Delivery System Implantation
    Joshua M. Rosenow
    91 The Surgical Technique of Vagus Nerve Stimulator Implantation
    Jeffrey W. Cozzens

Product details

  • No. of pages: 1088
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: May 5, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080921396

About the Editors in Chief

Elliot Krames

Affiliations and Expertise

Pacific Pain Treatment Centers, San Francisco, CA, USA Medical Director, Anesthesiology, Pain Medicine

P. Hunter Peckham

Dr. Peckham is the Donnell Institute Professor of Biomedical Engineering and Orthopaedics at Case Western Reserve University and Director, Cleveland Functional Electrical Stimulation Center. The major area of Dr. Peckham's research is in rehabilitation engineering and neuroprostheses. He’s also the Founder for the Institute for Functional Restoration at the Case Western School of Medicine and the Co-Director of MetroHealth Rehabilitation Institute of Ohio. A holder of eight patents, he is a member of multiple councils, Dr. Peckham is also a fellow of the American Institute of Medical and Biological Engineering.

Affiliations and Expertise

Donnell Institute Professor of Biomedical Engineering and Orthopaedics at Case Western Reserve University and Director, Cleveland Functional Electrical Stimulation Center.

Ali Rezai

Dr. Rezai is currently executive chair and vice president of neurosciences for WVU Medicine. He also serves as associate dean and the John D. Rockefeller IV tenured professor in neurosciences at the WVU School of Medicine. Dr. Rezai has published over 150 peer reviewed articles, more than 30 book chapters, and serves on the editorial board of five journals. Dr. Rezai is currently the Past President of the Congress of Neurological Surgeons (CNS), the largest neurosurgical societies in the world, as well as the Past President North American Neuromodulation Society (NANS), and the American Society of Stereotactic and Functional Neurosurgery (ASSFN).Dr. Rezai’s research focuses on mechanisms of neurostimulation, and developing neuromodulation devices and novel therapeutic strategies for treatment of neurological disorders.

Affiliations and Expertise

executive chair and vice president of neurosciences for WVU Medicine; associate dean and the John D. Rockefeller IV tenured professor in neurosciences at the WVU School of Medicine, West Virginia University, Morgantown, WV USA

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