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Neuroendocrinology - 1st Edition - ISBN: 9781483232287, 9781483275048


1st Edition

Volume I

Editors: Luciano Martini William F. Ganong
eBook ISBN: 9781483275048
Imprint: Academic Press
Published Date: 1st January 1966
Page Count: 794
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Neuroendocrinology, Volume I, is the first in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.

Table of Contents


List of Contributors


Contents of Volume II

Chapter 1. Neuroendocrine Integrating Mechanisms

I. Introduction

II. Neural Control of Endocrine Secretion

III. Actions of Hormones on the Brain

IV. Hormones and Developmental Processes

V. Comparative Neuroendocrinology

VI. Conclusions


Chapter 2. The Anatomy of the Hypothalamus and Pituitary Gland

I. Introduction

II. The Hypothalamus

III. The Pituitary Gland


Chapter 3. Limbic and Other Neural Pathways That Regulate Endocrine Function

I. Introduction

II. Cortical and Subcortical Gray Components

III. Fibrous Connections Intrinsic to Limbic System Cortex and Subcortical Gray

IV. Extramural Pathways Linking Limbic System Cortex with Areas in the Brain Stem

V. Interrelationships between Neocortex and Limbic System

VI. Conclusion


Chapter 4. Stereotaxic Techniques and the Production of Lesions

I. Limitations of the Lesion Technique

II. Stereotaxic Technique

III. Electric Parameters for Lesion Production

IV. Mechanisms of Lesion Production

V. Changes in Lesions with Time

VI. The Transition Zone between Stimulation and Lesion

VII. Electrodes

VIII. Injection Techniques


Appendix. Bibliography of Stereotaxic and Other Brain Atlases Arranged by Species

Chapter 5. Neurosecretion

I. The Concept of Neurosecretion

II. Nature of the Neurosecretory Cell

III. Nature of the Neurosecretory Process

IV. Nature of the Neurosecretory Material

V. Occurrence of Neurosecretion in Invertebrate Animals

VI. Occurrence of Neurosecretion in Vertebrate Animals

VII. Secretion by Non-neuronal Nervous Tissue and "Neuroglandular" Areas of Possible Endocrine Significance

VIII. Neurosecretion versus Secretion by Neurons and the Evolution of Neurosecretory Systems: Conclusions


Chapter 6. Control of Vasopressin Secretion

I. Introduction

II. Methods of Study

III. Stimuli Causing Vasopressin Release

IV. Central Mechanisms

V. Cholinergic and Adrenergic Steps in Control of Vasopressin Release

VI. Conclusions and Summary


Chapter 7. Neural Control of Oxytocin Secretion

I. Introduction

II. Role of Oxytocin in Reproduction and Lactation

III. Nervous Mechanisms Regulating Oxytocin Secretion

IV. Concluding Comments


Chapter 8. Hypothalamic Releasing Factors and the Neurovascular Link between the Brain and the Anterior Pituitary

I. Introduction

II. Physiological Implications of the Anatomical Relationships of the Anterior Pituitary

III. Evidence Suggesting a Functional Role for the Portal Vessels

IV. Hypophyseal Releasing and Inhibiting Factors

V. Summary


Chapter 9. Control of Adrenocorticotropic Hormone Secretion

I. Introduction

II. Methods Used for Evaluating Changes in Adrenocorticotropic Hormone Secretion

III. The Hypothalamus and Adrenocorticotropic Hormone Secretion

IV. The Role of Nervous Structures Other than the Hypothalamus in the Control of Adrenocorticotropic Hormone Secretion

V. Steroid Feedback Mechanisms in the Control of Adrenocorticotropic Hormone Secretion

VI. Short Feedback Mechanisms in the Control of Adrenocorticotropic Hormone Secretion

VII. The Role of Stress in the Control of Adrenocorticotropic Hormone Secretion

VIII. Conclusions


Chapter 10. Adrenocorticotropic Hormone Secretion in the Fetus and Infant

I. Introduction

II. Pituitary-Adrenocortical System in the Fetus

III. Pituitary-Adrenocortical System in the Infant

IV. Conclusions


Chapter 11. Neural and Other Mechanisms Regulating Aldosterone Secretion

I. Effect of Adrenocorticotropic Hormone on Control of Aldosterone Secretion

II. Effect of Renin-Angiotensin System on Aldosterone Secretion

III. Effect of Electrolytes on Aldosterone Secretion

IV. Neural Mechanisms Regulating Aldosterone Secretion

V. Summary


Chapter 12. Control of Thyrotropic Hormone Secretion

I. Introduction

II. The Pituitary-Thyroid Axis as a Feedback System

III. Neural Control of Thyrotropin Secretion

IV. Factors Affecting Pituitary-Thyroid Activity

V. Conclusion


Chapter 13. Control of Growth Hormone Secretion

I. Introduction

II. Growth Hormone during Fetal Development and at Different Ages during Life Span

III. Growth Hormone in Pregnancy

IV. Growth Hormone in Dwarfism and Acromegaly

V. Nervous Control of Growth Hormone Secretion

VI. Influence of Metabolic Factors and Various Conditions on Growth Hormone Secretion

VII. Influence of Hormonal Factors on Growth Hormone Secretion

VIII. Influence of the Environment or Stressful Factors on Growth Hormone Secretion

IX. Conclusions


Chapter 14. Control of Gonadotropin Secretion in the Male

I. Introduction

II. Comparative Roles of Endocrine, Central Nervous, and Peripheral Nervous Systems

III. Components of the Neuroendocrine Reflex

IV. The Feedback Control of Gonadotropin Secretion

V. Conclusions


Chapter 15. Control of Gonadotropin Secretion in the Female

I. Factors Influencing Gonadotropin Secretion

II. Effects of Various Experimental Procedures on Gonadotropin Secretion

III. Some Structural and Functional Data Concerning the Hypothalamo-Hypophyseal Connection

IV. Neural Mechanisms Controlling Gonadotropin Secretion

V. Neurohormonal Feedback Mechanisms in the Control of Gonadotropin Secretion

VI. Summary and Conclusions


Chapter 16. Control of Mammary Growth and Lactation

I. Introduction

II. Mammary Growth

III. Lactation

IV. Relation of the Hypothalamus to Mammary Growth and Lactation

V. Control of Prolactin Secretion

VI. Conclusions


Author Index

Subject Index


No. of pages:
© Academic Press 1966
1st January 1966
Academic Press
eBook ISBN:

About the Editors

Luciano Martini

Affiliations and Expertise

Department of Endocrinology, University of Milano, Milano, Italy

William F. Ganong

Ratings and Reviews