Volume I

1st Edition - January 1, 1966

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  • Editors: Luciano Martini, William F. Ganong
  • eBook ISBN: 9781483275048

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Neuroendocrinology, Volume I, is the first in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.

Table of Contents

  • Dedication

    List of Contributors


    Contents of Volume II

    Chapter 1. Neuroendocrine Integrating Mechanisms

    I. Introduction

    II. Neural Control of Endocrine Secretion

    III. Actions of Hormones on the Brain

    IV. Hormones and Developmental Processes

    V. Comparative Neuroendocrinology

    VI. Conclusions


    Chapter 2. The Anatomy of the Hypothalamus and Pituitary Gland

    I. Introduction

    II. The Hypothalamus

    III. The Pituitary Gland


    Chapter 3. Limbic and Other Neural Pathways That Regulate Endocrine Function

    I. Introduction

    II. Cortical and Subcortical Gray Components

    III. Fibrous Connections Intrinsic to Limbic System Cortex and Subcortical Gray

    IV. Extramural Pathways Linking Limbic System Cortex with Areas in the Brain Stem

    V. Interrelationships between Neocortex and Limbic System

    VI. Conclusion


    Chapter 4. Stereotaxic Techniques and the Production of Lesions

    I. Limitations of the Lesion Technique

    II. Stereotaxic Technique

    III. Electric Parameters for Lesion Production

    IV. Mechanisms of Lesion Production

    V. Changes in Lesions with Time

    VI. The Transition Zone between Stimulation and Lesion

    VII. Electrodes

    VIII. Injection Techniques


    Appendix. Bibliography of Stereotaxic and Other Brain Atlases Arranged by Species

    Chapter 5. Neurosecretion

    I. The Concept of Neurosecretion

    II. Nature of the Neurosecretory Cell

    III. Nature of the Neurosecretory Process

    IV. Nature of the Neurosecretory Material

    V. Occurrence of Neurosecretion in Invertebrate Animals

    VI. Occurrence of Neurosecretion in Vertebrate Animals

    VII. Secretion by Non-neuronal Nervous Tissue and "Neuroglandular" Areas of Possible Endocrine Significance

    VIII. Neurosecretion versus Secretion by Neurons and the Evolution of Neurosecretory Systems: Conclusions


    Chapter 6. Control of Vasopressin Secretion

    I. Introduction

    II. Methods of Study

    III. Stimuli Causing Vasopressin Release

    IV. Central Mechanisms

    V. Cholinergic and Adrenergic Steps in Control of Vasopressin Release

    VI. Conclusions and Summary


    Chapter 7. Neural Control of Oxytocin Secretion

    I. Introduction

    II. Role of Oxytocin in Reproduction and Lactation

    III. Nervous Mechanisms Regulating Oxytocin Secretion

    IV. Concluding Comments


    Chapter 8. Hypothalamic Releasing Factors and the Neurovascular Link between the Brain and the Anterior Pituitary

    I. Introduction

    II. Physiological Implications of the Anatomical Relationships of the Anterior Pituitary

    III. Evidence Suggesting a Functional Role for the Portal Vessels

    IV. Hypophyseal Releasing and Inhibiting Factors

    V. Summary


    Chapter 9. Control of Adrenocorticotropic Hormone Secretion

    I. Introduction

    II. Methods Used for Evaluating Changes in Adrenocorticotropic Hormone Secretion

    III. The Hypothalamus and Adrenocorticotropic Hormone Secretion

    IV. The Role of Nervous Structures Other than the Hypothalamus in the Control of Adrenocorticotropic Hormone Secretion

    V. Steroid Feedback Mechanisms in the Control of Adrenocorticotropic Hormone Secretion

    VI. Short Feedback Mechanisms in the Control of Adrenocorticotropic Hormone Secretion

    VII. The Role of Stress in the Control of Adrenocorticotropic Hormone Secretion

    VIII. Conclusions


    Chapter 10. Adrenocorticotropic Hormone Secretion in the Fetus and Infant

    I. Introduction

    II. Pituitary-Adrenocortical System in the Fetus

    III. Pituitary-Adrenocortical System in the Infant

    IV. Conclusions


    Chapter 11. Neural and Other Mechanisms Regulating Aldosterone Secretion

    I. Effect of Adrenocorticotropic Hormone on Control of Aldosterone Secretion

    II. Effect of Renin-Angiotensin System on Aldosterone Secretion

    III. Effect of Electrolytes on Aldosterone Secretion

    IV. Neural Mechanisms Regulating Aldosterone Secretion

    V. Summary


    Chapter 12. Control of Thyrotropic Hormone Secretion

    I. Introduction

    II. The Pituitary-Thyroid Axis as a Feedback System

    III. Neural Control of Thyrotropin Secretion

    IV. Factors Affecting Pituitary-Thyroid Activity

    V. Conclusion


    Chapter 13. Control of Growth Hormone Secretion

    I. Introduction

    II. Growth Hormone during Fetal Development and at Different Ages during Life Span

    III. Growth Hormone in Pregnancy

    IV. Growth Hormone in Dwarfism and Acromegaly

    V. Nervous Control of Growth Hormone Secretion

    VI. Influence of Metabolic Factors and Various Conditions on Growth Hormone Secretion

    VII. Influence of Hormonal Factors on Growth Hormone Secretion

    VIII. Influence of the Environment or Stressful Factors on Growth Hormone Secretion

    IX. Conclusions


    Chapter 14. Control of Gonadotropin Secretion in the Male

    I. Introduction

    II. Comparative Roles of Endocrine, Central Nervous, and Peripheral Nervous Systems

    III. Components of the Neuroendocrine Reflex

    IV. The Feedback Control of Gonadotropin Secretion

    V. Conclusions


    Chapter 15. Control of Gonadotropin Secretion in the Female

    I. Factors Influencing Gonadotropin Secretion

    II. Effects of Various Experimental Procedures on Gonadotropin Secretion

    III. Some Structural and Functional Data Concerning the Hypothalamo-Hypophyseal Connection

    IV. Neural Mechanisms Controlling Gonadotropin Secretion

    V. Neurohormonal Feedback Mechanisms in the Control of Gonadotropin Secretion

    VI. Summary and Conclusions


    Chapter 16. Control of Mammary Growth and Lactation

    I. Introduction

    II. Mammary Growth

    III. Lactation

    IV. Relation of the Hypothalamus to Mammary Growth and Lactation

    V. Control of Prolactin Secretion

    VI. Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 794
  • Language: English
  • Copyright: © Academic Press 1966
  • Published: January 1, 1966
  • Imprint: Academic Press
  • eBook ISBN: 9781483275048

About the Editors

Luciano Martini

Affiliations and Expertise

Department of Endocrinology, University of Milano, Milano, Italy

William F. Ganong

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