Molecular Mechanisms and Therapeutic Interventions

1st Edition - January 11, 2019

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  • Editor: Swapan Ray
  • Paperback ISBN: 9780128120057
  • eBook ISBN: 9780128120040

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Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions.

Key Features

  • Comprehensively covers the histopathological characterization, molecular mechanisms, and most recent therapeutic interventions in neuroblastoma
  • Includes recent developments and therapeutic interventions for neuroblastoma, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy
  • Presents a broad scope that provides basic researchers, practitioners and students with the most current overview of recent advances


Researchers, practitioners, residents and students in the fields of neurooncology, neurology, and cancer research

Table of Contents

  • 1. Neuroblastoma pathology and classification
    2. Role of genetic and epigenetic alterations in pathogenesis of neuroblastoma
    3. Neuroblastoma molecular biology and promising therapeutic targets
    4. The GD2-targeted immunotherapy of neuroblastoma
    5. Targeting angiogenesis in neuroblastoma
    6. Autophagy and novel therapeutic strategies in neuroblastoma
    7. Energy metabolism and new therapeutic opportunities in neuroblastoma
    8. Multimodality imaging for diagnosis of neuroblastoma
    9. Immunotherapy for neuroblastoma
    10. Advances in surgical treatment of neuroblastoma
    11. Role of stemness factors in neuroblastoma: Neuroblastoma stem cells, tumor microenvironment, and chemoresistance
    12. Current pharmacotherapy for neuroblastoma
    13. Current challenges in the management of neuroblastoma
    14. Novel therapeutic targets in neuroblastoma
    15. Current and future strategies for treatment of relapsed neuroblastoma
    16. Current evidence in favor of a tumor suppressor role of Krüppel-like factor 4 in malignant neuroblastoma
    17. Modulation of expression of microRNA as a therapeutic strategy in malignant neuroblastoma

Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: January 11, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128120057
  • eBook ISBN: 9780128120040

About the Editor

Swapan Ray

Dr. Ray is senior faculty at the University of South Carolina School of Medicine with a deep interest in neuro-oncology. He has been working in the neuroblastoma field for more than 10 years has over 175 publications in the field and is funded by the federal, state, and private funding agencies for conducting his research. His laboratory focuses on the understanding of the cellular and molecular mechanisms of pathogenesis of malignant diseases such as glioblastoma, neuroblastoma, and Ewing's sarcoma and the development of novel therapeutic strategies for neurological disorders. He has trained many students, postdoctoral fellows, and junior faculty members as well.

Affiliations and Expertise

Professor, Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA

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