This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.

Key Features

  • Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment
  • Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders
  • A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain


Neurologists and neuroscience research workers

Table of Contents

1. Psychiatry and neuroscience history (M.M. Weber, G.E. Berrios and E.J. Engstrom, Munich, Germany, Cambridge, UK and Berlin, Germany). 2. Receptor signaling and the cell biology of synaptic transmission (J-Z. Yu and M. M. Rasenick, Chicago, USA). 3. Human genetics of schizophrenia (S. Claes, Y-L. Tang, C.F. Gillespie and J.F. Cubells, Leuven, Belgium and Atlanta, USA). 4. Neurological and psychiatric aspects of emotion (S.E. Sarkstein and D. Tranel, Perth, Australia and Iowa City, USA). 5. Research methods: cognitive neuropsychological methods (L. Clark, O. Boxer, B.J. Sahakian and R.M. Bilder, Cambridge, UK and Los Angeles, USA). 6. Structural imaging in psychiatric disorders (K.R. Rama Krishnan, Durham, USA). 7. Human functional neuroimaging (C. Kilts and T.D. Ely, Little Rock and Atlanta, USA). 8. Neurotransmitters and neuropeptides in depression (A-M. Bao, H.G. Ruhé, S-F. Gao and D.F. Swaab, Hangzhou, China and Amsterdam, The Netherlands). 9. Animal models of psychiatric disorders (G.F. Koob and A. Zimmer, La Jolla, USA and Bonn, Germany). 10. Psychiatric epidemiology (S.H. Juul and C.B. Nemeroff, Atlanta and Miami, USA). 11. Emerging methods in the molecular biology of neuropsychiatric disorders (E.B. Binder and K.J. Ressler, Atlanta, USA and Munich, Germany). 12. Clinical psychoneuroimmunology (M.R. Irwin and M. Rothermundt, Los Angeles, USA and Muenster, Germany). 13. Psychiatric rating scales (D. Maust, M. Cristancho, L. Gray, S. Rushing, C. Tjoa and M.E. Thase, Philadelphia, USA). 14. Unipolar depression (C.M. Pariante and C.B. Nemeroff, London, UK and Atlanta, USA). 15. Bipolar disorder (D.J. Smith, E.A. Whitham and S.N. Ghaemi, Cardiff, UK and Boston, USA). 16. The neurobiology and treatment of late-life depression (U. Hegerl, P. Holtzheimer, R. Mergl and W. McDonald, Leipzig, Germany and Atlanta, USA). 17. Seasonal affective disorder (K.V. Danilenko and R.D. Levitan, Novosibirsk, Russia and Toronto, Canada). 18. Biological and clinical framework for


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© 2012
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About the editors

Thomas Schlaepfer

Vice Chair and Professor of Psychiatry and Psychotherapy and Dean of Medical Education, Department of Psychiatry, University of Bonn, Germany; Associate Professor of Psychiatry and Mental Health, The Johns Hopkins University School of Medicine, Baltimore, Maryland

Charles Nemeroff

Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA