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Neurobiology of Depression - 1st Edition - ISBN: 9780128133330, 9780128133347

Neurobiology of Depression

1st Edition

Road to Novel Therapeutics

Editors: Joao Quevedo Andre Carvalho Carlos Zarate
Paperback ISBN: 9780128133330
eBook ISBN: 9780128133347
Imprint: Academic Press
Published Date: 3rd January 2019
Page Count: 471
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Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.

Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.

Key Features

  • Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations
  • Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics
  • Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression


Advanced students and researchers in neuroscience, psychology, medicine, health sciences, and pharmacology

Table of Contents

  1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoC
    Elizabeth D. Ballard, Ioline D. Henter and Carlos A. Zarate, Jr.
    2. The Role of Environmental and Psychosocial Factors in Depression
    Gordon Parker
    3. Gene-Environment Interactions and Epigenetic Mechanisms in Depression
    Magdalene C. Jawahar, Catherine G. Toben and Bernhard T. Baune
    4. Pathophysiology of Cognitive Impairment in Depression
    Christopher R. Bowie, Melissa Milanovic and Tanya Tran
    5. Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics
    Theodore P. Beauchaine, Daniel N. Klein, Erin Knapton and Aimee Zisner
    6. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications
    Minal Jaggar, Sashaina E. Fanibunda, Shreya Ghosh, Ronald S. Duman and Vidita A. Vaidya
    8. Neuro-Immune Interactions in Depression: Mechanisms and Translational Implications
    Helena M. Abelaira, Ritele H. Silva, Anelise S. Carlessi, João Quevedo and Gislaine Z. Réus
    9. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational Implications
    Theo Rein, Oliver Ambrée, Gabriel R. Fries, Virginie Rappeneau, Ulrike Schmidt and Chadi Touma
    10. Intracellular Signaling Pathways Implicated in the Pathophysiology of Depression
    Gislaine Z. Réus, Jaqueline S. Generoso, Ana Lúcia S. Rodrigues and João Quevedo
    11. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of Depression
    Mousa Botros, Gabrielle Hodgins and Charles B. Nemeroff
    12. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and Resilience
    Ming-Hu Han, Scott J. Russo and Eric J. Nestler
    13. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of Depression
    Jane A. Foster
    14. Optogenetics: Illuminating the Neural Circuits of Depression
    Muir J. and Bagot R.C.
    15. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of Depression
    Adrian L. Lopresti
    16. Obesity and Depression: Shared Pathophysiology and Translational Implications
    Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon and Lucile Capuron
    17. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and Implications
    Jessica Hatch and Benjamin I. Goldstein
    18. Poststroke Depression: Pathophysiology and Treatment Strategies
    Yun-Ju Lai and Louise D. McCullough
    19. Is Depression Associated With Accelerated Aging? Mechanisms and Implications
    Daniel Lindqvist, Naomi M. Simon and Owen M. Wolkowitz
    20. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and Implications
    Nicole J. LeBlanc, Naomi M. Simon, Charles F. Reynolds, III, M. Katherine Shear, Natalia Skritskaya and Sidney Zisook
    21. A Neural Circuit-Based Model for Depression Anchored in a Synthesis
    of Insights From Functional Neuroimaging
    Andrea N. Goldstein-Piekarski and Leanne M. Williams
    22. Could Depression be Preventable? Evidence and Perspectives
    Scott B. Patten
    23. Treating Depression in the Era of Precision Medicine: Challenges and Perspectives
    Michael Musker and Ma-Li Wong
    24. Neurobiological Aspects of Functional Recovery in Major Depressive Disorder
    Trisha Chakrabarty, David Sarfati and Raymond W. Lam
    25. Diet and Depression: From Epidemiology to Novel Therapeutics
    Wolfgang Marx, Erin Hoare and Felice Jacka
    26. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological Mechanism
    Brendon Stubbs and Felipe Schuch
    27. Antidepressants and Suicidality—
    Controversies and Possible Mechanisms
    Josef Witt-Doerring and Sanjay Mathew
    28. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in Depression
    Dwight F. Newton, Corey Fee, Yuliya S. Nikolova and Etienne Sibille
    29. Biomarker-Based Treatment Selection: A Precision Medicine Approach for Depression
    Jennifer L. Furman and Madhukar H. Trivedi
    30. Implications of Pharmacogenomics in Depression Pathophysiology and Treatment
    Forbes M.P., Jaksa P., Eyre H.A. and Bousman C.
    31. Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms
    Lucia Bulubas, Eva Mezger, Daniel Keeser, Frank Padberg and Andre R. Brunoni
    32. Electroconvulsive Therapy for Depression: Neurobiological Mechanisms
    Peter Mulders, Stevie Jaarsveld, Indira Tendolkar and Philip van Eijndhoven
    33. Deep Brain Stimulation: Mechanisms Underpinning Antidepressant Effects
    Sonia Torres-Sanchez, Laura Perez-Caballero and Esther Berrocoso
    34. Novel Therapeutic Targets for Major Depressive Disorder
    Max A. Lazar and Roger S. McIntyre
    35. The Search for Rapid Acting Antidepressants: Research Synthesis and Perspectives
    Gerard Sanacora, Brandon M. Kitay and Samuel T. Wilkinson
    36. Pediatric Depression
    Frances Rice and Naomi Warne
    37. Depression in Women
    Molly M. Hyer and Gretchen N. Neigh
    38. Advances in the Neurobiology of Late-Life Depression
    Breno Satler Diniz and Antonio Lucio Teixeira


No. of pages:
© Academic Press 2019
3rd January 2019
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Joao Quevedo

João Quevedo, MD, PhD is Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, where he is Vice-Chair for Faculty Development and Outreach, Director of the Translational Psychiatry Program, and Director of the Treatment-Resistant Mood Disorder Program. Before moving to Houston he was Dean at the University of Southern Santa Catarina Medical School, Criciúma, SC, Brazil, where he is still Adjunct Professor of Psychiatry. He is also an 1A research fellow (the highest level) of the National Council for Scientific and Technological Development (CNPq), Brazil; an affiliate member of the Brazilian Academy of Sciences (an award given to the most notable researchers in Brazil under the age of 40), associate editor of the Revista Brasileira de Psiquiatria, vice president of the Santa Catarina State Association of Psychiatry, and Director of the Continuous Medical Education Program in Psychiatry (PROPSIQ) of the Brazilian Association of Psychiatry. Dr. Quevedo’s research interest is the neurobiology of psychiatric disorders, particularly mood disorders, and he is a specialist in animal models of depression and bipolar disorder. He is author of nearly 500 publications and 6 scientific books.

Affiliations and Expertise

Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA

Andre Carvalho

André F Carvalho is associate professor at the Department of Psychiatry at the University of Toronto and a clinician scientist at the Centre for Addiction and Mental Health (CAMH). He was elected member of the board of councilors of the International Society of Bipolar Disorders (2016-2017) and the vice-chair of the section of private practice psychiatry of the World Psychiatric Association (2015-2017). He sits on the editorial board of several international peer-reviewed journals, including Psychotherapy and Psychosomatics, and has served as a peer reviewer for several leading journals and funding agencies. He is an expert in mood disorders, psychiatric epidemiology, and evidence-based mental health. Dr. Carvalho is a sought after speaker in several national and international meetings, and is the author of over 300 publications.

Affiliations and Expertise

Associate Professor, Department of Psychiatry, Temerty Medical School, University of Toronto, Toronto, ON, Canada

Carlos Zarate

Dr. Zarate completed his residency training in psychiatry at the Massachusetts Mental Health Center/Brockton VAMC division. He later completed a fellowship in Clinical Psychopharmacology at McLean Hospital of the Consolidated Department of Psychiatry, Harvard Medical School and remained on staff at McLean Hospital as the Director of the Bipolar and Psychotic Disorders Outpatient Services. From 1998 to 2000 Dr. Zarate was the Chief of the Bipolar and Psychotic Disorders Program at the University of Massachusetts Medical School. In 2001, he joined the Mood and Anxiety Disorders Program at NIMH. His achievements and awards include the Ethel-DuPont Warren Award and Livingston Awards, Consolidated Department of Psychiatry, Harvard Medical School; Outstanding Psychiatrist Research Award, Massachusetts Psychiatric Association; Program for Minority Research Training in Psychiatry, APA; the National Alliance for Research on Schizophrenia and Depression Young Investigator Award; National Alliance for Research on Schizophrenia and Depression Independent Investigator Award; the National Institutes of Health Director’s Award Scientific/Medical, the 2011 Brain & Behavior Research Foundation Award for Bipolar Mood Disorder Research, the 2013 National Institute of Health Director’s Award—Scientific/Medical Achievement and Mogens Schou Research Award: Bipolar Disorder and the Simon-Bolivar Award American Psychiatric Association; 2015 Ruth L. Kirschtein Mentoring Award NIH and the Astute Clinician Lecture Award, NIH; the 2019 ACNP Dolores Shockley Minority Mentoring Award; and in 2019 was promoted to NIH Distinguished Investigator, NIMH, NIH. Dr. Zarate is a fellow of the American College of Neuropsychopharmacology and member of the Society of Biological Psychiatry and the Society for Neuroscience. Dr. Zarate’s research focuses on the pathophysiology and development of novel therapeutics for treatment-resistant mood disorders as well as the study of biomarkers and neural correlates of treatment response.

Affiliations and Expertise

Chief, Experimental and Therapeutics Branch/Section on Neurobiology and Treatment of Mood and Anxiety Disorders, and Clinical Professor of Psychiatry and Behavioral Sciences, George Washington University, USA

Ratings and Reviews