Neurobiology of Cytokines

Neurobiology of Cytokines

Methods in Neurosciences, Vol. 16

1st Edition - September 22, 1993

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  • Editor: Errol B. De Souza
  • eBook ISBN: 9781483217550

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Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

Table of Contents

  • Contributors to Volume


    Volumes in Series

    Section I General Aspects

    1. Pharmacological, Biochemical, and Molecular Biological Studies on Cytokine Receptors

    2. Genetic Regulation and Activities of an Interleukin 1 Receptor Antagonist Protein

    3. Identification of Intracellular Mediators of the Actions of Cytokines: Identifying Proteins Involved in Kinase Signaling Pathways

    4. Measurement of Transport of Cytokines across the Blood-Brain Barrier

    Section II Anatomical Localization Studies

    5. In Situ Hybridization Techniques for Localization of Interleukin 1 and Interleukin 1 Receptor Antagonist mRNA in Brain

    6. Immunocytochemical Methods for Localization of Cytokines in Brain

    7. Localization of Type I Interleukin 1 Receptor mRNA in Brain and Endocrine Tissues by in Situ Hybridization Histochemistry

    8. Identification, Autoradiographic Localization, and Modulation of Interleukin 1 Receptors in Brain-Endocrine-Immune Axis: Methodology and Overview

    9. c-fos-Based Functional Mapping of Central Pathways Subserving Effects of Interleukin 1 on the Hypothalamo-Pituitary-Adrenal Axis

    10. Anatomical and Functional Approaches to Study of Interleukin 2 and Its Receptors in Brain

    Section III Neuroendocrine Actions

    11. Endocrine Aspects of Neuroimmunomodulation: Methods and Overview

    12. Determining Role and Sources of Endogenous Interleukin 1 in Pituitary-Adrenal Activation in Response to Stressful and Inflammatory Stimuli

    13. In Vivo and in Vitro Methods for Studying Effects of Cytokines on Adrenocorticotropic Hormone, Arginine Vasopressin, and Oxytocin Secretion

    14. In Vivo and in Vitro Models for Evaluating Effects of Interleukin 1 on Hypothalamic-Pituitary-Gonadal Axis

    15. Methodological Evaluation of Sites and Mechanisms of Action Involved in Neuroendocrine Effects of Cytokines

    16. In Vivo and in Vitro Methods for Studying Effects of Tumor Necrosis Factor on Pituitary Cells

    17. Determination of Direct Effects of Cytokines on Release of Neuropeptides from Rat Hypothalamus by an in Vitro Method

    18. Effects of Interleukin 1 on ß-Endorphin Secretion in AtT-20 Pituitary Cells: Methods and Overview


Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: September 22, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9781483217550

About the Editor

Errol B. De Souza

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