Neural Stem Cells and Adult Neurogenesis

Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research.

For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons’ contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format.

• Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research
• Details adult neurogenesis and its role in behavior, stroke and disease
• Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Neuroscientists, graduate and undergraduate students in biological and biomedical sciences, post-doctoral fellows, researchers

Section I. Stem Cells
1. History and ethics of stem cells
2. Stem cells: From embryos to adults
3. The stem cell niche
4. Induced pluripotent stem cells

Section II. Adult Neurogenesis – The Hippocampus
5. Introduction to adult neurogenesis
6. Adult neurogenesis in the hippocampus
7. Adult neurogenesis in the subventricular zone
8. Adult neurogenesis in health and disease