Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including:

  1. Neural regeneration in lower vertebrates
  2. Neural regeneration in the peripheral nervous system
  3. Neural regeneration in the central nervous system
  4. Transplantation-mediated neural regeneration
  5. Clinical and translational research on neural regeneration

The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China.

Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries.

This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.

Key Features

  • Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration
  • Highly translational and clinically-relevance
  • International authors who are leaders in their respective fields
  • Vivid art work making the chapters easily understood


Researchers and clinicians at all levels of neural regeneration research, including graduate students, postdoctors, and scientists.

Table of Contents

  • List of Contributors
  • Foreword
  • Preface
  • Section I. Introduction
    • Chapter 1. Advances and Challenges for Neural Regeneration Research
      • 1. Nervous System, Nerve Injury, and Neural Regeneration
      • 2. Technological Advances in Neural Regeneration Research
      • 3. PNS Regeneration
      • 4. CNS Regeneration
      • 5. Challenges and Opportunities
  • Section II. Neural Regeneration in Lower Vertebrates
    • Chapter 2. Functional Regeneration and Remyelination in the Zebrafish Optic Nerve
      • 1. Introduction to Zebrafish Optic Nerve Injury (ONI) as a Model for Studying Regeneration and Remyelination
      • 2. Time Course of Optic Nerve Regeneration in Adult Zebrafish
      • 3. Intrinsic and Extrinsic Mechanisms of Axon Regeneration
      • 4. Genetic Manipulation Tools Are Very Useful for Studying Regeneration in Zebrafish
      • 5. In vivo Imaging of Nerve Regeneration in Zebrafish Larvae
      • 6. Imaging Remyelination in Zebrafish
      • 7. Behavior Tests Indexed the Visual Functional Recovery after Optic Nerve Injury
      • 8. Future Directions
      • 9. Conclusions
    • Chapter 3. Central Nerve Regeneration in Reptiles
      • 1. Introduction
      • 2. Timing of Regeneration—General Compared to Fish and Frogs, Including Geckos, etc
      • 3. Retinal Ganglion Cell Survival
      • 4. Glia: Friend or Foe?
      • 5. Growth Promotion: Neurotrophins, Extracellular Matrix, Gefiltin, Polysialic Acid–Neural Cell Adhesion Molecule, Comparison with Development
      • 6. Topography and Refinement: NMDA/AMPA/GABA and Synaptic Proteins
      • 7. Conclusion: Relevance to Mammals
      • 8. Conclusions
    • Chapter 4. Axon Regeneration in the Lamprey Spinal Cord
      • 1. The Need for Lower Vertebrate Models of Axon Regeneration in the Central Nervous System
      • 2. General Biology of the Lamprey
      • 3. The Central


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© 2015
Academic Press
Electronic ISBN:
Print ISBN:

About the editors

Kwok-Fai So

Chair Professor and Head of the Department of Anatomy, Jessie Ho Professor in Neuroscience at The University of Hong Kong

Xiao-Ming Xu

Scientific Director, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute Professor and Mari Hulman George Chair of Neurological Surgery Professor, Department of Anatomy and Cell Biology Indiana University, USA