Preface
Acknowledgments
1 Introduction
2 Consideration of Some Features of the Organization and Ultrastructure of Nervous Systems
I. Neurons
A. Neuronal Processes
B. The Fine Structure of the Soma
II. Neuroglia
A. The Neuroglia in Vertebrates
B. The Neuroglia in Invertebrates
III. The Organization of Nervous Tissue
A. General Organization
B. Neuron-Neuron Relationships—Synapses
C. Morphological Relationship between Neurons and Glia in Invertebrates
D. Morphological Relationship between Neurons and Glia in Vertebrates
E. Some Features of Neuron and Glia Relationships Common to Both Invertebrates and Vertebrates
3 The Functions of Glia and Aspects of Functional Neuron-Glia Interrelationships
I. Myelination
II. Trophic and Metabolic Relationships
A. Trophic Function of Glia in Invertebrates
B. Neuronal Nutrition and Trophic Function of Glia in Vertebrates
III. The Role of Glia in the Water and Ion Balances of the Nervous System and in the Blood Brain Barrier
A. Vertebrates
B. Invertebrates
IV. Electrical Activity and Glia
4 Extracellular Space and the Pathways of Ions and Nutrients
I. Introduction
II. Ground Substance
III. The Extent of the Extracellular Space
A. Evidence from Electron Microscopical Studies
B. Estimations from Studies with Tracer Molecules
C. Estimations from Measurements of Electrical Impedance
IV. Glia, Extracellular Space, and the Pathways of Ions and Nutrients
5 Structure and Function in Biological Membranes: Background Material
I. Monolayers, Bilayers, Micelles, and Liquid Crystals: Definitions
II. Intermolecular Forces
A. The Hydrogen Bond
B. Electrostatic Forces
C. Polarization or Induction Forces
D. London-van der Waals Dispersion Forces
III. Water Structure and Hydrophobic Bonding
A. Hydrophobic Bond Formation
IV. Semiconductivity, Piezoelectricity, and Ferromagnetism
A. Semiconductivity
B. Piezoelectricity
C. Ferromagnetism
V. Chemistry of Electron Microscopy
VI. Synthetic Membrane Systems
A. Lipid Bilayers
B. Monolayers
C. Liquid Crystals (Mesophases)
6 Structure and Function in Biological Membranes: Recent Theories
I. Membrane Composition
II. Molecular Organization in Membranes
A. Bimolecular Leaflet Models
B. Dynamic Micellar Models
C. Membranes as Repeating Subunits
D. A Mosaic or Lattice Model
E. Other Views on Biological Barriers
F. Bioenergetics
7 Structure and Function in Neural Membranes: Chemical Composition, Some Recent Theories, and Conclusions Regarding Present Knowledge of Neuron-Glia Interrelationships
I. The Diversity of Membranes in Nervous Systems
II. Chemical Composition of Nervous Systems
A. Mature Myelin
B. Differences between Central and Peripheral Nervous System Myelin
C. Developing Myelin
D. Neuronal Soma, Synaptosomes, and Subcellular Particles
E. Gangliosides and Neural Membranes
F. Glia
G. A Summary of the Differences in Chemical Composition between Neural Membranes
III. Some Recent Theories of Structure and Function in Neural Membranes
IV. Conclusions Regarding Present Knowledge of Neuron-Glia Interrelationships
Appendix: An Outline Classification of Animals
References
Author Index
Subject Index